Search Results - "Koretsky, A. P"

Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes by Zabow, G., Dodd, S. J., Koretsky, A. P.

“…A shape-changing sensor made of pairs of magnetic disks spaced by swellable hydrogel material removes all need for optical access by operating in the nuclear…”
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In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging by Pautler, R G, Silva, A C, Koretsky, A P

“…Development of efficient imaging techniques to trace neuronal connections would be very useful. Manganese ion (Mn2+) is an excellent T1 contrast agent for…”
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Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-alpha by Kubota, Toru, McTiernan, Charles F, Frye, Carole S, Slawson, Susan E, Lemster, Bonnie H, Koretsky, Alan P, Demetris, A. Jake, Feldman, Arthur M

“…The failing human heart expresses tumor necrosis factor-alpha (TNF-alpha). However, its pathophysiological significance is not clear. We previously reported…”
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Magnetic Resonance Imaging of Perfusion Using Spin Inversion of Arterial Water by Williams, Donald S., Detre, John A., Leigh, John S., Koretsky, Alan P.

“…A technique has been developed for proton magnetic resonance imaging (MRI) of perfusion, using water as a freely diffusable tracer, and its application to the…”
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Lambda exonuclease digestion of CGG trinucleotide repeats by Conroy, R. S, Koretsky, A. P, Moreland, J

“…Fragile X syndrome and other trinucleotide diseases are characterized by an elongation of a repeating DNA triplet. The ensemble-averaged lambda exonuclease…”
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Imaging Transgenic Animals by Budinger, T. F, Benaron, D. A, Koretsky, A. P

“…Transgenic and eugenic animals as small as 30 g can be studied noninvasively by radionuclides with resolutions of 1-2 mm, by MRI with resolution of 100 m and…”
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Manganese-Enhanced MRI of the Brain in Healthy Volunteers by Sudarshana, D M, Nair, G, Dwyer, J T, Dewey, B, Steele, S U, Suto, D J, Wu, T, Berkowitz, B A, Koretsky, A P, Cortese, I C M, Reich, D S

“…The manganese ion is used as an intracellular MR imaging contrast agent to study neuronal function in animal models, but it remains unclear whether…”
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Perfusion imaging by Detre, J A, Leigh, J S, Williams, D S, Koretsky, A P

“…Measurement of tissue perfusion is important for the functional assessment of organs in vivo. Here we report the use of 1H NMR imaging to generate perfusion…”
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Manganese-Enhanced MRI in Patients with Multiple Sclerosis by Suto, D J, Nair, G, Sudarshana, D M, Steele, S U, Dwyer, J, Beck, E S, Ohayon, J, McFarland, H, Koretsky, A P, Cortese, I C M, Reich, D S

“…Cellular uptake of the manganese ion, when administered as a contrast agent for MR imaging, can noninvasively highlight cellular activity and disease processes…”
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The fabrication of uniform cylindrical nanoshells and their use as spectrally tunable MRI contrast agents by Zabow, G, Dodd, S J, Moreland, J, Koretsky, A P

“…A new form of tunable magnetic resonance imaging agent based on precisely dimensioned cylindrical magnetic nanoshells is introduced. Using top-down…”
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Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion by Silva, A C, Williams, D S, Koretsky, A P

“…The extraction fraction of vascular water in rat brain is investigated by means of diffusion measurements of arterial spin labeled water at varying cerebral…”
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Phosphocreatine protects transgenic mouse liver expressing creatine kinase from hypoxia and ischemia by Miller, K, Halow, J, Koretsky, A P

“…Creatine kinase (CK) is normally found at high levels in muscle and brain and catalyzes the reaction phosphocreatine (PCr) + MgADP + H+<==>creatine (Cr) +…”
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Cardiac MRI of the normal and hypertrophied mouse heart by Slawson, S E, Roman, B B, Williams, D S, Koretsky, A P

“…With the development of recent transgenic techniques, studies involving mice offer opportunities to increase understanding of cardiac disease. This provides…”
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Insights into cellular energy metabolism from transgenic mice by Koretsky, A P

“…Rapid progress in manipulating the mouse genome now makes it possible to express any cloned gene in virtually any cell type of the mouse. Homologous…”
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NMR measurement of perfusion using arterial spin labeling without saturation of macromolecular spins by Zhang, W, Silva, A C, Williams, D S, Koretsky, A P

“…When measuring perfusion by arterial spin labeling, saturation of tissue macromolecular spins during arterial spin labeling greatly decreases tissue water…”
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Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function by Lin, Y J, Koretsky, A P

“…Present techniques for functional MRI rely on detecting changes in hemodynamics that result as a consequence of brain activation. It would be useful if MRI…”
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Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling by Silva, A C, Zhang, W, Williams, D S, Koretsky, A P

“…The model used for calculating perfusion by MRI techniques that use endogenous water as a tracer assumes that arterial water is a freely diffusible tracer…”
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Interpretation of ³¹P NMR saturation transfer experiments: what you can't see might confuse you. Focus on "Standard magnetic resonance-based measurements of the Pi→ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles" by Balaban, R S, Koretsky, A P

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Changes in the mitochondrial proteome from mouse hearts deficient in creatine kinase by KERNEC, FLORENCE, UNLU, MUSTAFA, LABEIKOVSKY, WLADIMIR, MINDEN, JONATHAN S, KORETSKY, ALAN P

“…1 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 2 Carnegie Mellon…”
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Investigation of cell physiology in the animal using transgenic technology by Koretsky, A P

“…Over the past 10 years significant progress has been made in techniques for manipulating the genome of the animal. Production of transgenic mice has led to…”
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