Search Results - "Korennykh, Alexei"

Structural Basis of the Unfolded Protein Response by Korennykh, Alexei, Walter, Peter

“…The unfolded protein response (UPR) is a network of intracellular signaling pathways that maintain the protein-folding capacity of the endoplasmic reticulum…”
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Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery by Donovan, Jesse, Rath, Sneha, Kolet-Mandrikov, David, Korennykh, Alexei

“…Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting endoribonuclease, RNase L. Consensus in the field indicates that…”
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Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering by Li, Han, Korennykh, Alexei V., Behrman, Shannon L., Walter, Peter

“…Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that…”
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Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1 by Donovan, Jesse, Dufner, Matthew, Korennykh, Alexei

“…The human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1 (hOAS1) polymerizes ATP into 2′,5′-linked iso-RNA (2-5A) involved in innate…”
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The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled) by Estrella, Michael A., Du, Jin, Chen, Li, Rath, Sneha, Prangley, Eliza, Chitrakar, Alisha, Aoki, Tsutomu, Schedl, Paul, Rabinowitz, Joshua, Korennykh, Alexei

“…Nocturnin (NOCT) is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has been proposed that NOCT…”
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Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3 by Donovan, Jesse, Whitney, Gena, Rath, Sneha, Korennykh, Alexei

“…The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are…”
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Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response by Han, Yuchen, Donovan, Jesse, Rath, Sneha, Whitney, Gena, Chitrakar, Alisha, Korennykh, Alexei

“…One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology…”
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Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line by Li, Yize, Banerjee, Shuvojit, Goldstein, Stephen A, Dong, Beihua, Gaughan, Christina, Rath, Sneha, Donovan, Jesse, Korennykh, Alexei, Silverman, Robert H, Weiss, Susan R

“…ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of leads to a severe…”
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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response by Rath, Sneha, Prangley, Eliza, Donovan, Jesse, Demarest, Kaitlin, Wingreen, Ned S., Meir, Yigal, Korennykh, Alexei

“…Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for programmed RNA degradation by the 2-5A/RNase L complex in cells of all mammals. This…”
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The unfolded protein response signals through high-order assembly of Ire1 by Shokat, Kevan M, Finer-Moore, Janet, Korostelev, Andrei A, Zhang, Chao, Stroud, Robert M, Korennykh, Alexei V, Egea, Pascal F, Walter, Peter

“…Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/endoribonuclease Ire1. Ire1 excises an intron from…”
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Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity by Rubio, Claudia, Pincus, David, Korennykh, Alexei, Schuck, Sebastian, El-Samad, Hana, Walter, Peter

“…Accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Ire1, an ER-resident…”
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Messenger RNA targeting to endoplasmic reticulum stress signalling sites by Aragón, Tomás, van Anken, Eelco, Pincus, David, Serafimova, Iana M., Korennykh, Alexei V., Rubio, Claudia A., Walter, Peter

“…The unfolding story The accumulation of misfolded proteins activates the unfolded protein response in the endoplasmic reticulum. The transmembrane protein Ire1…”
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Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome by Rath, Sneha, Donovan, Jesse, Whitney, Gena, Chitrakar, Alisha, Wang, Wei, Korennykh, Alexei

“…Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease…”
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Structural and functional basis for RNA cleavage by Ire1 by Korennykh, Alexei V, Korostelev, Andrei A, Egea, Pascal F, Finer-Moore, Janet, Stroud, Robert M, Zhang, Chao, Shokat, Kevan M, Walter, Peter

“…The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the…”
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Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 by Korennykh, Alexei V, Egea, Pascal F, Korostelev, Andrei A, Finer-Moore, Janet, Stroud, Robert M, Zhang, Chao, Shokat, Kevan M, Walter, Peter

“…Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the…”
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Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic by Mendez, Aaron S, Alfaro, Jennifer, Morales-Soto, Marisol A, Dar, Arvin C, McCullagh, Emma, Gotthardt, Katja, Li, Han, Acosta-Alvear, Diego, Sidrauski, Carmela, Korennykh, Alexei V, Bernales, Sebastian, Shokat, Kevan M, Walter, Peter

“…Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease…”
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Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes by Han, Yuchen, Whitney, Gena, Donovan, Jesse, Korennykh, Alexei

“…2′,5′-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2-5As induce self-association…”
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Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1 by van Anken, Eelco, Pincus, David, Coyle, Scott, Aragón, Tomás, Osman, Christof, Lari, Federica, Gómez Puerta, Silvia, Korennykh, Alexei V, Walter, Peter

“…Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded…”
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A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation by Oakes, Samantha R, Gallego-Ortega, David, Stanford, Prudence M, Junankar, Simon, Au, Wendy Wing Yee, Kikhtyak, Zoya, von Korff, Anita, Sergio, Claudio M, Law, Andrew M K, Castillo, Lesley E, Allerdice, Stephanie L, Young, Adelaide I J, Piggin, Catherine, Whittle, Belinda, Bertram, Edward, Naylor, Matthew J, Roden, Daniel L, Donovan, Jesse, Korennykh, Alexei, Goodnow, Christopher C, O'Bryan, Moira K, Ormandy, Christopher J

“…We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes…”
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Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins by Korennykh, Alexei V, Correll, Carl C, Piccirilli, Joseph A

“…Alpha-sarcin and ricin represent two structurally and mechanistically distinct families of site-specific enzymes that block translation by irreversibly…”
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