Search Results - "Kordulewska, Natalia"
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Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line
Published in International journal of molecular sciences (20-12-2021)“…Hyperactivity of the immune system in the gastrointestinal tract leads to the development of chronic, inflammation-associated disorders. Such diseases,…”
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Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms-The Risk of Malignant Tumors and Other Diseases
Published in International journal of molecular sciences (22-10-2020)“…Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because of the very short half-life of…”
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Modulatory Effects of Osthole on Lipopolysaccharides-Induced Inflammation in Caco-2 Cell Monolayer and Co-Cultures with THP-1 and THP-1-Derived Macrophages
Published in Nutrients (31-12-2020)“…Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they may disrupt tight junctions and induce cytokines (CKs) secretion…”
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The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
Published in International journal of molecular sciences (01-11-2023)“…Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of…”
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Vitamin D Metabolic Pathway Components in Orthopedic Patientes-Systematic Review
Published in International journal of molecular sciences (08-12-2022)“…Vitamin D takes part in the functioning of many processes that ensure the homeostasis of the body. In orthopedics, it is indicated as an inseparable element…”
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Vitamin D Receptor ( VDR ) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
Published in Nutrients (01-01-2021)“…Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background…”
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Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy - in vitro study Short communication
Published in Journal of pharmacy & pharmaceutical sciences (2019)“…Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine,…”
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
Published in Frontiers in immunology (2024)“…Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in…”
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Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene ( VDR ) May Have an Impact on Acute Pancreatitis (AP) Development: A Prospective Study in Populations of AP Patients and Alcohol-Abuse Controls
Published in International journal of molecular sciences (29-06-2018)“…Vitamin D imbalance is suggested to be associated with the development of pancreatitis. Single nucleotide polymorphisms (SNPs), Apa-1, Bsm-1, Fok-1, and Taq-1,…”
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Genetic Polymorphism of β-Casein Gene in Polish Red Cattle-Preliminary Study of A1 and A2 Frequency in Genetic Conservation Herd
Published in Animals (Basel) (20-06-2019)“…Although there is growing interest in Red cow's milk in Poland, to date there are few reports investigating the characteristics of milk components in the…”
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TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients
Published in BMC gastroenterology (12-11-2021)“…The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP)…”
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Cytokines concentrations in serum samples from allergic children—Multiple analysis to define biomarkers for better diagnosis of allergic inflammatory process
Published in Immunobiology (1979) (01-11-2018)“…Allergic diseases can expand at any age as a result of complicated interaction of environmental and genetic factors. Through the years, studies have found that…”
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High Expression of IL-1RI and EP₂ Receptors in the IL-1β/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs-Osthole in Inhibition COX-2
Published in International journal of molecular sciences (07-01-2019)“…Osthole (7-methoxy-8-isopentenylcoumarin) is natural coumarin isolated from the fruit of (L.) , which is commonly used in medical practice of traditional…”
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Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis
Published in Cells (Basel, Switzerland) (28-12-2021)“…The Toll-like receptor (TLR) family signature has been linked to the etiopathology of atopic dermatitis (AD), a chronic inflammatory skin disease associated…”
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Serum cytokine levels in children with spectrum autism disorder: Differences in pro- and anti-inflammatory balance
Published in Journal of neuroimmunology (15-12-2019)“…Autism Spectrum Disorders (ASDs) is a developmental and neurological disorder that affects all aspects of social communication, with limited and stereotypical…”
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Stability of interleukin-1β, -4, -6, -8, -10, -13, interferon-γ and tumor necrosis factor-α in human sera after repetitive freeze-thaw cycles and long storage
Published in Journal of pharmaceutical and biomedical analysis (20-03-2021)“…•Cytokines (CKs) level should be measured immediately after the serum sample collection.•Serum samples storage for 24 h resulted in a decrease of 7 out of 8…”
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Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-[kappa]B in Normal Human Keratinocytes and Fibroblasts
Published in Journal of inflammation research (31-03-2022)“…Introduction: Osthole (OST), an active compound isolated from Cnidium monnieri, is used in traditional Chinese medicine to treat a variety of human diseases…”
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The Effect of Osthole on Transient Receptor Potential Channels: A Possible Alternative Therapy for Atopic Dermatitis
Published in Journal of inflammation research (01-01-2024)“…Chronic recurrent skin inflammation and severe itching in patients with atopic dermatitis (AD) significantly impair their quality of life. The H4 histamine…”
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
Published in British journal of dermatology (1951) (07-07-2023)“…The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier…”
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A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole
Published in International immunopharmacology (01-07-2019)“…Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by Diagnosis and Statistic Manual 5 (DSM-5) as persistent social interaction and…”
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