Search Results - "Korchinski, E D"

Effects of food on the pharmacokinetics of methylphenidate by MIDHA, K. K, MCKAY, G, RAWSON, M. J, KORCHINSKI, E. D, HUBBARD, J. W

“…To test the hypothesis that the pharmacokinetics of d-methylphenidate (d-MPH) would be altered by food ingested before administration of an immediate release…”
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Pharmacokinetics of chlorpromazine and key metabolites by YEUNG, P. K.-F, HUBBARD, J. W, KORCHINSKI, E. D, MIDHA, K. K

“…A study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (i.v.) dose (10 mg) and…”
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Absolute bioavailability and stereoselective pharmacokinetics of doxepin by Yan, J.-H., Hubbard, J. W., McKay, G., Korchinski, E. D., Midha, K. K.

“…1. Commercial doxepin contains geometric isomers in the proportions Z : E = 15:85. Z -doxepin and its metabolite Z - N -desmethyldoxepin are both active…”
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Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine by MURALIDHARAN, G, COOPER, J. K, HAWES, E. M, KORCHINSKI, E. D, MIDHA, K. K

“…Quindine is a potent inhibitor of CYP2D6 (debrisoquine 4-hydroxylase). Its effect on the disposition of chlorpromazine was investigated in ten healthy…”
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Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans by SRINIVAS, N. R, HUBBARD, J. W, KORCHINSKI, E. D, MIDHA, K. K

“…A definitive enantioselective pharmacokinetic evaluation of dl-threo-methylphenidate (MPH) was carried out in 11 healthy volunteers, all of whom received, in a…”
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Effect of quinidine on the interconversion kinetics between haloperidol and reduced haloperidol in humans : implications for the involvement of cytochrome P450IID6 by YOUNG, D, MIDHA, K. K, FOSSLER, M. J, HAWES, E. M, HUBBARD, J. W, MCKAY, G, KORCHINSKI, E. D

“…Haloperidol (HAL) is a potent butyrophenone antipsychotic agent which is reversibly metabolized to reduced haloperidol (RHAL). In order to determine if this…”
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N(+)-glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs by Luo, H, Hawes, E M, McKay, G, Korchinski, E D, Midha, K K

“…1. Metabolic N(+)-glucuronidation of aliphatic tertiary amine antidepressant or antipsychotic drugs was investigated in man. In each case, urine was collected…”
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Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat by Lin, G, Hawes, E M, McKay, G, Korchinski, E D, Midha, K K

“…1. The metabolism of thioridazine was studied in adult male volunteers, female rat and female dog after oral administration of 50 mg, 20 mg/kg and 100 mg over…”
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Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans by Srinivas, N R, Hubbard, J W, Korchinski, E D, Midha, K K

“…Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate (MPH) and its major metabolite, dl-ritalinic acid (RA), were examined in a cohort of…”
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The identification of urinary metabolites of doxepin in patients by Shu, Y Z, Hubbard, J W, Cooper, J K, McKay, G, Korchinski, E D, Kumar, R, Midha, K K

“…The metabolism of doxepin was investigated in three patients who provided cumulative urine samples on each of 3 successive days. These samples were examined by…”
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Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase by MURALIDHARAN, G, HAWES, E. M, MCKAY, G, KORCHINSKI, E. D, MIDHA, K. K

“…Healthy male volunteers (n = 13) took a single oral dose of 60.3 mg of methoxyphenamine HCl with and without prior administration of either quinidine (250 mg…”
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Stereoselective pharmacokinetics of doxepin isomers by MIDHA, K. K, HUBBARD, J. W, MCKAY, G, HAWES, E. M, KORCHINSKI, E. D, GURNSEY, T, COOPER, J. K, SCHWEDE, R

“…Commercial preparations of the tricyclic anti-depressant doxepin contain 15% of the more active cis-doxepin and 85% of the trans-isomer. The single dose…”
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N(+)-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans by Luo, H, Hawes, E M, McKay, G, Korchinski, E D, Midha, K K

“…1. Representative drugs of the various structural classes of H1 antihistamines were chosen for study. The drugs chosen (class name in parentheses) were…”
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An ultrasensitive method for the measurement of haloperidol and reduced haloperidol in plasma by high-performance liquid chromatography with coulometric detection by Midha, K K, Cooper, J K, Hawes, E M, Hubbard, J W, Korchinski, E D, McKay, G

“…A new analytical method has been developed for the simultaneous quantitation of haloperidol and reduced haloperidol in plasma. The method is based on high…”
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The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human by Lin, G, Hawes, E M, McKay, G, Cooper, S F, Korchinski, E D, Midha, K K

“…1. The metabolism of sulforidazine was studied in female dogs and adult male humans after oral administration of 37.5 mg and 25.0 mg, respectively. 2…”
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Interconversion between haloperidol and reduced haloperidol in healthy volunteers by CHAKRABORTY, B. S, HUBBARD, J. W, HAWES, E. M, MCKAY, G, COOPER, J. K, GURNSEY, T, KORCHINSKI, E. D, MIDHA, K. K

“…The interconversion between haloperidol (HAL) and reduced haloperidol (RHAL) was examined following their separate administration in low (5 mg) single oral…”
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Metabolism of phenothiazine and butyrophenone antipsychotic drugs. A review of some recent research findings and clinical implications by Hubbard, J W, Midha, K K, Hawes, E M, McKay, G, Marder, S R, Aravagiri, M, Korchinski, E D

“…Whereas some metabolites of antipsychotic drugs are psychoactive and contribute to clinical improvement, recent studies have provided evidence that certain…”
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Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans by Srinivas, N R, Hubbard, J W, Quinn, D, Korchinski, E D, Midha, K K

“…1. Two pilot studies were carried out to investigate the enantioselective pharmacokinetics of methylphenidate (MPH) in children with attention…”
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Intersubject variation in the pharmacokinetics of haloperidol and reduced haloperidol by Midha, K K, Chakraborty, B S, Ganes, D A, Hawes, E M, Hubbard, J W, Keegan, D L, Korchinski, E D, McKay, G

“…Single oral doses (5 mg) of haloperidol were administered to 36 healthy men (26 black, 10 white) of whom 28 (22 black, 6 white) completed the study. Plasma…”
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The metabolism of piperidine-type phenothiazine antipsychotic agents. III. Mesoridazine in dog, human and rat by Lin, G, Hawes, E M, McKay, G, Korchinski, E D, Midha, K K

“…1. The metabolism of mesoridazine was studied in female rats (20 mg/kg, oral), female dogs (50 mg over 30 h, oral) and adult male volunteers (25 mg, oral). 2…”
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