Search Results - "Korchak, Helen M."

Regulation of TNF-induced oxygen radical production in human neutrophils: role of δ-PKC by Kilpatrick, Laurie E., Sun, Shuang, Li, Haiying, Vary, Thomas C., Korchak, Helen M.

“…δ‐PKC is a key regulator of early events in the assembly and activation of the NADPH oxidase elicited by TNF in adherent neutrophils. In human neutrophils,…”
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Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC) by Kilpatrick, Laurie E., Standage, Stephen W., Li, Haiying, Raj, Nichelle R., Korchak, Helen M., Wolfson, Marla R., Deutschman, Clifford S.

“…Targeted inhibition of δ‐PKC exerted a lung‐protective effect and significantly attenuated pulmonary inflammatory cell infiltration, disruption of lung…”
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Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R) by Chernova, Irene, Lai, Jian‐Ping, Li, Haiying, Schwartz, Lynnae, Tuluc, Florin, Korchak, Helen M., Douglas, Steven D., Kilpatrick, Laurie E.

“…Substance P (SP) is a potent modulator of monocyte/macrophage function. The SP‐preferring receptor neurokinin‐1 receptor (NK1R) has two forms: a full‐length…”
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Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of δ-PKC and ERK1/2 by Kilpatrick, Laurie E., Sun, Shuang, Mackie, DeMauri, Baik, Fred, Li, Haiying, Korchak, Helen M.

“…TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF‐mediated antiapoptotic signaling; a…”
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Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT) by YANEY, Gordon C, CIVELEK, Vildan N, RICHARD, Ann-Marie, DILLON, Joseph S, DEENEY, Jude T, HAMILTON, James A, KORCHAK, Helen M, TORNHEIM, Keith, CORKEY, Barbara E, BOYD, Aubrey E

“…Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT) Gordon C. Yaney , Vildan N. Civelek , Ann-Marie Richard , Joseph S. Dillon ,…”
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Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells by Yaney, Gordon C., Korchak, Helen M., Corkey, Barbara E.

“…Abstract Pancreatic β-cells contain protein kinase C (PKC) isoforms that may play a role in insulin secretion. Activity of PKC classes (cPKC, nPKC, aPKC) and…”
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A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil by Kilpatrick, Laurie E, Lee, Julia Y, Haines, Kathleen M, Campbell, Donald E, Sullivan, Kathleen E, Korchak, Helen M

“…The proinflammatory cytokine tumor necrosis factor (TNF)-alpha has been implicated in the attenuation of neutrophil spontaneous apoptosis during sepsis…”
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Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils by Kilpatrick, Laurie E, Sun, Shuang, Korchak, Helen M

“…TNF is implicated in the attenuation of neutrophil constitutive apoptosis during sepsis. Antiapoptotic signaling is mediated principally through the TNF…”
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Release of inflammatory mediators from stimulated neutrophils by Weissmann, G, Smolen, J E, Korchak, H M

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Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms by Yaney, Gordon C, Fairbanks, Jamison M, Deeney, Jude T, Korchak, Helen M, Tornheim, Keith, Corkey, Barbara E

“…Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing…”
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Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils by Kilpatrick, L E, Song, Y H, Rossi, M W, Korchak, H M

“…Tumor necrosis factor-alpha (TNF-alpha) triggers degranulation and oxygen radical release in adherent neutrophils. The p60TNF receptor (p60TNFR) is responsible…”
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Reversible Ca2+-dependent Translocation of Protein Kinase C and Glucose-induced Insulin Release by Deeney, J T, Cunningham, B A, Chheda, S, Bokvist, K, Juntti-Berggren, L, Lam, K, Korchak, H M, Corkey, B E, Berggren, P O

“…It has been reported that protein kinase C (PKC) interacts at multiple sites in β-cell stimulus-secretion coupling. Nevertheless, there is still controversy…”
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Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo by Kaplan, H B, Edelson, H S, Korchak, H M, Given, W P, Abramson, S, Weissmann, G

“…Human blood neutrophils exposed to appropriate stimuli aggregate, degranulate and generate superoxide anion (O2-). These responses are anteceded by…”
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Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro by Marcus, A J, Broekman, M J, Safier, L B, Ullman, H L, Islam, N, Sherhan, C N, Rutherford, L E, Korchak, H M, Weissmann, G

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Selective roles for α-PKC in positive signaling for O2− generation and calcium mobilization but not elastase release in differentiated HL60 cells by Korchak, Helen M., Dorsey, Lindsay B., Li, Haiying, Mackie, DeMauri, Kilpatrick, Laurie E.

“…Protein kinase C (PKC) isotypes and Ca2+ mobilization have been implicated in phagocytic cell functions such as O2− generation. Ca/DG-dependent α-PKC and β-PKC…”
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Lytic effects of Actinobacillus actinomycetemcomitans leukotoxin on human neutrophil cytoplasts by Iwase, M, Korchak, H M, Lally, E T, Berthold, P, Taichman, N S

“…Actinobacillus actinomycetemcomitans leukotoxin lysed human neutrophil cytoplasts. The reaction was associated with a rapid influx of extracellular calcium, a…”
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Interferon-γ corrects the respiratory burst defect in vitro in monocyte-derived macrophages from glycogen storage disease type 1b patients by MCCAWLEY, L. J, KORCHAK, M, CUTILLI, J. R, STANLEY, C. A, BAKER, L, DOUGLAS, S. D, KILPATRICK, L

“…Glycogen storage disease (GSD) type 1b is accompanied by decreased respiratory burst activity in peripheral blood phagocytic cells (i.e. monocytes and…”
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Roles for βII-Protein Kinase C and RACK1 in Positive and Negative Signaling for Superoxide Anion Generation in Differentiated HL60 Cells by Korchak, Helen M., Kilpatrick, Laurie E.

“…β-Protein kinase (PKC) is essential for ligand-initiated assembly of the NADPH oxidase for generation of superoxide anion (O⨪2). Neutrophils and neutrophilic…”
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Selective Role for β-Protein Kinase C in Signaling for O⨪2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells by Korchak, Helen M., Rossi, Michael W., Kilpatrick, Laurie E.

“…A role for protein kinase C (PKC) isotypes is implicated in the activation of phagocytic cell functions. An antisense approach was used to selectively deplete…”
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Roles for βII-Protein Kinase C and RACK1 in Positive and Negative Signaling for Superoxide Anion Generation in Differentiated HL60 Cells by Helen M. Korchak, Laurie E. Kilpatrick

“…β-Protein kinase (PKC) is essential for ligand-initiated assembly of the NADPH oxidase for generation of superoxide anion (O⨪ 2 ). Neutrophils and…”
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