Search Results - "Korc, Murray"

Pancreatic cancer–associated stroma production by Korc, Murray, M.D

“…Abstract One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of…”
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Pancreatic cancer-associated diabetes is an "exosomopathy" by Korc, Murray

“…Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin…”
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Pancreatic cancer: Stroma and its current and emerging targeted therapies by Kota, Janaiah, Hancock, Julie, Kwon, Jason, Korc, Murray

“…Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal human malignancies with a 5-year survival rate of 8%. Dense, fibrotic stroma…”
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A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer by Lai, Xianyin, Wang, Mu, McElyea, Samantha Deitz, Sherman, Stuart, House, Michael, Korc, Murray

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that often presents clinically at an advanced stage and that may be confused with…”
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Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells by Liu, Fang, Korc, Murray

“…Aberrant activation of Cyclin D-Cdk4/6 signaling pathway is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly…”
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Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer by Andersen, Dana K, Korc, Murray, Petersen, Gloria M, Eibl, Guido, Li, Donghui, Rickels, Michael R, Chari, Suresh T, Abbruzzese, James L

“…The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic…”
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Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes by Joshi, Gayatri K, Deitz-McElyea, Samantha, Liyanage, Thakshila, Lawrence, Katie, Mali, Sonali, Sardar, Rajesh, Korc, Murray

“…MicroRNAs are short noncoding RNAs consisting of 18–25 nucleotides that target specific mRNA moieties for translational repression or degradation, thereby…”
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Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells by Enane, Francis O., Saunthararajah, Yogen, Korc, Murray

“…Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells. However, master regulators of apoptosis (e.g., p53, p16/CDKN2A) are…”
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Designer hydrogels: Shedding light on the physical chemistry of the pancreatic cancer microenvironment by Lin, Chien-Chi, Korc, Murray

“…Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer mortality in the United States, with a 5-year survival of ∼8%. PDAC is…”
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The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy by Principe, Daniel R, Underwood, Patrick W, Korc, Murray, Trevino, Jose G, Munshi, Hidayatullah G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival time of 10-12 months. Clinically, these poor outcomes are attributed to…”
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Driver mutations: A roadmap for getting close and personal in pancreatic cancer by Korc, Murray

“…Commentary to: Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM) Hannah…”
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Highly Specific Plasmonic Biosensors for Ultrasensitive MicroRNA Detection in Plasma from Pancreatic Cancer Patients by Joshi, Gayatri K, Deitz-McElyea, Samantha, Johnson, Merrell, Mali, Sonali, Korc, Murray, Sardar, Rajesh

“…MicroRNAs (miRs) are small noncoding RNAs that regulate mRNA stability and/or translation. Because of their release into the circulation and their remarkable…”
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Overview of pre-clinical and clinical studies targeting angiogenesis in pancreatic ductal adenocarcinoma by Craven, Kelly E, Gore, Jesse, Korc, Murray

“…Highlights • Pancreatic ductal adenocarcinoma (PDAC) is hypovascular. • Vascular endothelial growth factor A (gene: VEGFA) (VEGF-A) is overexpressed in PDAC. •…”
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Tobacco and alcohol as risk factors for pancreatic cancer by Korc, Murray, Jeon, Christie Y., Edderkaoui, Mouad, Pandol, Stephen J., Petrov, Maxim S.

“…Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying…”
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A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile by Cote, Gregory A, Gore, A Jesse, McElyea, Samantha D, Heathers, Laura E, Xu, Huiping, Sherman, Stuart, Korc, Murray

“…Accurate peripheral markers for the diagnosis of pancreatic ductal adenocarcinoma (PDAC) are lacking. We measured the differential expression of select…”
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Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer by Hart, Phil A, Bellin, Melena D, Andersen, Dana K, Bradley, David, Cruz-Monserrate, Zobeida, Forsmark, Christopher E, Goodarzi, Mark O, Habtezion, Aida, Korc, Murray, Kudva, Yogish C, Pandol, Stephen J, Yadav, Dhiraj, Chari, Suresh T

“…Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired…”
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Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia by SEELEY, E. Scott, CARRIERE, Catherine, GOETZE, Tobias, LONGNECKER, Daniel S, KORC, Murray

“…Primary cilia have been proposed to participate in the modulation of growth factor signaling pathways. In this study, we determined that ciliogenesis is…”
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Beyond Kras: MYC Rules in Pancreatic Cancer by Korc, Murray, MD

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14-3-3σ Modulates Pancreatic Cancer Cell Survival and Invasiveness by NEUPANE, Divas, KORC, Murray

“…Purpose: The purpose of the present study was to investigate the potential role of 14-3-3σ in pancreatic ductal adenocarcinoma (PDAC). Experimental Design:…”
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MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors by Liu, Xi, Sempere, Lorenzo F, Ouyang, Haoxu, Memoli, Vincent A, Andrew, Angeline S, Luo, Yue, Demidenko, Eugene, Korc, Murray, Shi, Wei, Preis, Meir, Dragnev, Konstantin H, Li, Hua, Direnzo, James, Bak, Mads, Freemantle, Sarah J, Kauppinen, Sakari, Dmitrovsky, Ethan

“…MicroRNAs (miRNAs) regulate gene expression. It has been suggested that obtaining miRNA expression profiles can improve classification, diagnostic, and…”
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