Search Results - "Koralov, Sergei"

Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells by Mimitou, Eleni P., Cheng, Anthony, Montalbano, Antonino, Hao, Stephanie, Stoeckius, Marlon, Legut, Mateusz, Roush, Timothy, Herrera, Alberto, Papalexi, Efthymia, Ouyang, Zhengqing, Satija, Rahul, Sanjana, Neville E., Koralov, Sergei B., Smibert, Peter

“…Multimodal single-cell assays provide high-resolution snapshots of complex cell populations, but are mostly limited to transcriptome plus an additional…”
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Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function by Kaufmann, Ulrike, Kahlfuss, Sascha, Yang, Jun, Ivanova, Elitza, Koralov, Sergei B., Feske, Stefan

“…Pathogenic Th17 cells play important roles in many autoimmune and inflammatory diseases. Their function depends on T cell receptor (TCR) signaling and…”
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High-resolution description of antibody heavy-chain repertoires in humans by Arnaout, Ramy, Lee, William, Cahill, Patrick, Honan, Tracey, Sparrow, Todd, Weiand, Michael, Nusbaum, Chad, Rajewsky, Klaus, Koralov, Sergei B

“…Antibodies' protective, pathological, and therapeutic properties result from their considerable diversity. This diversity is almost limitless in potential, but…”
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TET proteins and 5-methylcytosine oxidation in hematological cancers by Ko, Myunggon, An, Jungeun, Pastor, William A., Koralov, Sergei B., Rajewsky, Klaus, Rao, Anjana

“…Summary DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, and X‐chromosome inactivation…”
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IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia by Pylayeva-Gupta, Yuliya, Das, Shipra, Handler, Jesse S, Hajdu, Cristina H, Coffre, Maryaline, Koralov, Sergei B, Bar-Sagi, Dafna

“…A salient feature of pancreatic ductal adenocarcinoma (PDAC) is an abundant fibroinflammatory response characterized by the recruitment of immune and…”
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Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells by Shin, Boyoung, Benavides, Gloria A., Geng, Jianlin, Koralov, Sergei B., Hu, Hui, Darley-Usmar, Victor M., Harrington, Laurie E.

“…Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity. Here, we report a…”
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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice by Ko, Myunggon, Bandukwala, Hozefa S, An, Jungeun, Lamperti, Edward D, Thompson, Elizabeth C, Hastie, Ryan, Tsangaratou, Angeliki, Rajewsky, Klaus, Koralov, Sergei B, Rao, Anjana

“…The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to…”
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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids by LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-Kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales

“…Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic…”
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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis by Heichler, Christina, Scheibe, Kristina, Schmied, Anabel, Geppert, Carol I, Schmid, Benjamin, Wirtz, Stefan, Thoma, Oana-Maria, Kramer, Viktoria, Waldner, Maximilian J, Büttner, Christian, Farin, Henner F, Pešić, Marina, Knieling, Ferdinand, Merkel, Susanne, Grüneboom, Anika, Gunzer, Matthias, Grützmann, Robert, Rose-John, Stefan, Koralov, Sergei B, Kollias, George, Vieth, Michael, Hartmann, Arndt, Greten, Florian R, Neurath, Markus F, Neufert, Clemens

“…Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development…”
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MicroRNA regulation of B cell receptor signaling by Borbet, Timothy C., Hines, Marcus J., Koralov, Sergei B.

“…B lymphocytes play a central role in host immune defense. B cell receptor (BCR) signaling regulates survival, proliferation, and differentiation of B…”
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A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CLpro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19 by de Vries, Maren, Mohamed, Adil S, Prescott, Rachel A, Valero-Jimenez, Ana M, Desvignes, Ludovic, O’Connor, Rebecca, Steppan, Claire, Devlin, Joseph C, Ivanova, Ellie, Herrera, Alberto, Schinlever, Austin, Loose, Paige, Ruggles, Kelly, Koralov, Sergei B, Anderson, Annaliesa S, Binder, Joseph, Dittmann, Meike

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). There is a dire need for novel…”
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Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin by Boix-Amorós, Alba, Badri, Michelle H, Manasson, Julia, Blank, Rebecca B, Haberman, Rebecca H, Neimann, Andrea L, Girija, Parvathy V, Jimenez Hernandez, Anthony, Heguy, Adriana, Koralov, Sergei B, Bonneau, Richard, Clemente, Jose C, Scher, Jose U

“…To investigate the cutaneous microbiome spanning the entire psoriatic disease spectrum, and to evaluate distinguishing features of psoriasis (PsO) and…”
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Oncogenic fusions JAK up CD8+ cytotoxic CTCL by Buus, Terkild B., Koralov, Sergei B.

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Tissue-specific DNA demethylation is required for proper B-cell differentiation and function by Orlanski, Shari, Labi, Verena, Reizel, Yitzhak, Spiro, Adam, Lichtenstein, Michal, Levin-Klein, Rena, Koralov, Sergei B., Skversky, Yael, Rajewsky, Klaus, Cedar, Howard, Bergman, Yehudit

“…There is ample evidence that somatic cell differentiation during development is accompanied by extensive DNA demethylation of specific sites that vary between…”
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Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2-experienced individuals by Samanovic, Marie I, Cornelius, Amber R, Gray-Gaillard, Sophie L, Allen, Joseph Richard, Karmacharya, Trishala, Wilson, Jimmy P, Hyman, Sara Wesley, Tuen, Michael, Koralov, Sergei B, Mulligan, Mark J, Herati, Ramin Sedaghat

“…The use of coronavirus disease 2019 (COVID-19) vaccines will play the major role in helping to end the pandemic that has killed millions worldwide. COVID-19…”
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SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2 by Lu, Qiao, Liu, Jia, Zhao, Shuai, Gomez Castro, Maria Florencia, Laurent-Rolle, Maudry, Dong, Jianbo, Ran, Xiaojuan, Damani-Yokota, Payal, Tang, Hongzhen, Karakousi, Triantafyllia, Son, Juhee, Kaczmarek, Maria E., Zhang, Ze, Yeung, Stephen T., McCune, Broc T., Chen, Rita E., Tang, Fei, Ren, Xianwen, Chen, Xufeng, Hsu, Jack C.C., Teplova, Marianna, Huang, Betty, Deng, Haijing, Long, Zhilin, Mudianto, Tenny, Jin, Shumin, Lin, Peng, Du, Jasper, Zang, Ruochen, Su, Tina Tianjiao, Herrera, Alberto, Zhou, Ming, Yan, Renhong, Cui, Jia, Zhu, James, Zhou, Qiang, Wang, Tao, Ma, Jianzhu, Koralov, Sergei B., Zhang, Zemin, Aifantis, Iannis, Segal, Leopoldo N., Diamond, Michael S., Khanna, Kamal M., Stapleford, Kenneth A., Cresswell, Peter, Liu, Yue, Ding, Siyuan, Xie, Qi, Wang, Jun

“…Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engagement with immune cells, most express little, if any, of the…”
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Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas by Gumina, Megan E, Hooper, Madeline J, Zhou, Xiaolong A, Koralov, Sergei B

“…Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been…”
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B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage by Wong, Jason B., Hewitt, Susannah L., Heltemes-Harris, Lynn M., Mandal, Malay, Johnson, Kristen, Rajewsky, Klaus, Koralov, Sergei B., Clark, Marcus R., Farrar, Michael A., Skok, Jane A.

“…B-1a cells are long-lived, self-renewing innate-like B cells that predominantly inhabit the peritoneal and pleural cavities. In contrast to conventional B-2…”
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Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis by Kang, Jinsuk, Lienhard, Matthias, Pastor, William A., Chawla, Ashu, Novotny, Mark, Tsagaratou, Ageliki, Lasken, Roger S., Thompson, Elizabeth C., Surani, M. Azim, Koralov, Sergei B., Kalantry, Sundeep, Chavez, Lukas, Rao, Anjana

“…Dioxygenases of the TET (Ten-Eleven Translocation) family produce oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic…”
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Episodic Aspiration with Oral Commensals Induces a MyD88-dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to Streptococcus pneumoniae by Wu, Benjamin G, Sulaiman, Imran, Tsay, Jun-Chieh J, Perez, Luisanny, Franca, Brendan, Li, Yonghua, Wang, Jing, Gonzalez, Amber N, El-Ashmawy, Mariam, Carpenito, Joseph, Olsen, Evan, Sauthoff, Maya, Yie, Kevin, Liu, Xiuxiu, Shen, Nan, Clemente, Jose C, Kapoor, Bianca, Zangari, Tonia, Mezzano, Valeria, Loomis, Cynthia, Weiden, Michael D, Koralov, Sergei B, D'Armiento, Jeanine, Ahuja, Sunil K, Wu, Xue-Ru, Weiser, Jeffrey N, Segal, Leopoldo N

“…Cross-sectional human data suggest that enrichment of oral anaerobic bacteria in the lung is associated with an increased T-helper cell type 17 (Th17)…”
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