Search Results - "Korábečny, J."

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
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UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain by Mžik, M., Žďárová-Karasová, J., Chalupová, K., Korábečný, J, Palička, V., Šesták, V.

“…•Potent multitarget anti-Alzheimer’s compounds – S-K1025 and S-K1026 – fail to enter the brain in rats.•These compounds are prone to metabolism both in vitro…”
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UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data by Mzik, M., Sestak, V., Mezeiova, E., Korabecny, J., Hroch, M., Pejchal, J., Karasova-Zdarova, J.

“…Alzheimer's disease (AD) is one of the most common forms of dementia. Current anti-AD therapeutics exploit the cholinergic hypothesis of its pathophysiology;…”
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UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes by Novak, M., Svobodova, B., Konecny, J., Kuratkova, A., Nevosadova, L., Prchal, L., Korabecny, J., Lauschke, V.M., Soukup, O., Kučera, R.

“…Tacrine was the first drug used in the therapy of Alzheimer’s disease (AD) and is one of the leading structures frequently pursued in the drug discovery of…”
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P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment by Kassa, J, Korabecny, J, Nepovimova, E, Misik, J

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P.5.a.001 The effect of novel tacrine-related cholinesterase inhibitors on cognitive deficit induced by 3-quinuclidinyl benzilate in rats by Kassa, J, Korabecny, J, Misik, J

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Tetroxime: reactivation potency - in vitro and in silico study by Kuca, K, Korabecny, J, Dolezal, R, Nepovimova, E, Soukup, O, Gorecki, L, Musilek, K

“…Acetylcholinesterase (AChE) reactivators (oximes) are generally used as treatment in cases of nerve agent poisoning. There is no single oxime applicable in…”
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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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P.8.b.001 Interaction of acetylcholinesterase reactivators with albumin by Zemek, F, Sepsova, V, Drtinova, L, Korabecny, J, Pohanka, M, Zdarova Karasova, J, Kuca, K

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P-451 - Changes of cellular respiration in patients with alzheimer's disease by Hroudová, J, Fišar, Z, Korábečný, J, Kuča, K, Jirák, R, Raboch, J

“…Introduction Alzheimer's disease (AD) is the most frequent neurodegenerative disease, characterized by progressive decline in variety of higher brain functions…”
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P.760 Effects of novel cholinesterase inhibitors on mitochondrial respiration and MAO activity - in vitro study by Hroudová, J., Korábečný, J., Špilovská, K., Mezeiová, E., Górecki, L., Maliňák, D., Fišar, Z.

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7-methoxyderivative of tacrine is a potent open channel blocker of NMDA receptors by Horak, M., Kaniakova, M., Soukup, O., Korabecny, J.

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Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia by Janockova, J., Kobrlova, T., Mezeiova, E., Dolezal, R., Korabecny, J., Soukup, O.

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P.525 Tacrine derivatives as potent inhibitors of N-methyl-D-aspartate receptors with neuroprotective activity by Horak, M., Kaniakova, M., Soukup, O., Korabecny, J., Kleteckova, L., Vales, K.

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Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation by Novak, Martin, Vajrychova, Marie, Koutsilieri, Stefania, Sismanoglou, Despoina-Christina, Kobrlova, Tereza, Prchal, Lukas, Svobodova, Barbora, Korabecny, Jan, Zarybnicky, Tomas, Raisova-Stuchlikova, Lucie, Skalova, Lenka, Lauschke, Volker M., Kučera, Radim, Soukup, Ondrej

“…Tacrine was withdrawn from clinical use as a drug against Alzheimer’s disease in 2013, mainly due to drug-induced liver injury. The culprit of…”
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Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease by Soukup, O., Korabecny, J., Nepovimova, E., Karasova-Zdarova, J., Vales, K., Ricny, J., Jun, D., Kuca, K.

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1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats by Zdarova Karasova, Jana, Sestak, Vit, Korabecny, Jan, Mezeiova, Eva, Palicka, Vladimir, Kuca, Kamil, Mzik, Martin

“…•We present a validated UHPLC-HRMS method used for pharmacokinetic analysis of donepezil and its three structural “fragments”.•One of the fragments accumulates…”
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Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine by Zhou, Yitian, Arribas, Gabriel Herras, Turku, Ainoleena, Jürgenson, Tuuli, Mkrtchian, Souren, Krebs, Kristi, Wang, Yi, Svobodova, Barbora, Milani, Lili, Schulte, Gunnar, Korabecny, Jan, Gastaldello, Stefano, Lauschke, Volker M

“…Interindividual variability in drug response constitutes a major concern in pharmacotherapy. While polymorphisms in genes involved in drug disposition have…”
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