Search Results - "Kopylov, A. M"

Advances in the Application of Modified Nucleotides in SELEX Technology by Antipova, O. M., Zavyalova, E. G., Golovin, A. V., Pavlova, G. V., Kopylov, A. M., Reshetnikov, R. V.

“…Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and…”
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Characteristics of a New DNA Aptamer, Direct Inhibitor of Thrombin by Mazurov, A. V, Titaeva, E. V, Khaspekova, S. G, Storojilova, A. N, Spiridonova, V. A, Kopylov, A. M, Dobrovolsky, A. B

“…Characteristics of a new antithrombin DNA-aptamer RE31 were studied. This aptamer inhibited thrombin formation in human plasma catalyzed by exogenous…”
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Comparison of models of thrombin-binding 15-mer DNA aptamer by molecular dynamics simulation by Reshetnikov, R. V, Golovin, A. V, Kopylov, A. M

“…Two models of 15-mer thrombin-binding DNA aptamer (15TGT) were comparatively analyzed by molecular dynamics simulation using the GROMACS software package. The…”
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Visualization of fibrinogen αC regions and their arrangement during fibrin network formation by high‐resolution AFM by Protopopova, A. D., Barinov, N. A., Zavyalova, E. G., Kopylov, A. M., Sergienko, V. I., Klinov, D. V.

“…Summary Background Fibrinogen has been intensively studied with transmission electron microscopy and x‐ray diffraction. But until now, a complete 3D structure…”
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Classification of g-quadruplex DNA on the basis of the quadruplex twist angle and planarity of g-quartets by Reshetnikov, R V, Kopylov, A M, Golovin, A V

“…The present work is devoted to the analysis of the G-quadruplex DNA structure using the bioinformatics method. The interest towards quadruplex DNAs is…”
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Inhibition of Thrombin Activity with DNA-Aptamers by Dobrovolsky, A. B, Titaeva, E. V, Khaspekova, S. G, Spiridonova, V. A, Kopylov, A. M, Mazurov, A. V

“…The effects of two DNA aptamers (oligonucleotides) 15TBA and 31TBA (15- and 31-mer thrombin-binding aptamers, respectively) on thrombin activity were studied…”
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Use of Anti-EGFR Aptamer Construct GR20hh for Controlled Delivery of Doxorubicin into Patient-Derived Glioblastoma Cells by Ivanov, B. M., Antipova, O. M., Sliman, Ya. A., Samoylenkova, N. S., Pronin, I. N., Pavlova, G. V., Kopylov, A. M.

“…We report here a study of the potential for controlled delivery of doxorubicin (DOX) into glioblastoma (GB) cells as part of a non-covalent construct with an…”
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Specificity of Aptamers U2 and Gol1 to EGFR-Positive Human Glioblastoma Cells in Vitro by Dzarieva, F. M., Shamadykova, D. V., Sluchanko, O. V., Pavlova, S. A., Fab, L. V., Ryabova, A. V., Panteleev, D. Yu, Kopylov, A. M., Usachev, D. Yu, Golovin, A. V., Pavlova, G. V.

“…Overexpression of epidermal growth factor receptor (EGFR) and its mutations influence signal pathways leading to the proliferation, invasion, and increased…”
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Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure by Rozhdestvensky, T S, Kopylov, A M, Brosius, J, Hüttenhofer, A

“…By chemical and enzymatic probing, we have analyzed the secondary structure of rodent BC1 RNA, a small brain-specific non-messenger RNA. BC1 RNA is…”
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Mapping the ribosomal protein S7 regulatory binding site on mRNA of the E. coli streptomycin operon by Surdina, A. V, Rassokhin, T. I, Golovin, A. V, Spiridonova, V. A, Kopylov, A. M

“…In this work it is shown by deletion analysis that an intercistronic region (ICR) approximately 80 nucleotides in length is necessary for interaction with…”
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Molecular markers of neuro-oncogenesis in patients with glioblastoma by Kopylov, A M, Antipova, O A, Pavlova, G V

“…The problem of current treatment approaches to brain gliomas is short-term life expectancy in these patients. Apparently, it is required to change treatment…”
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Is it possible to detect surface antigen CD133 on patient-derived glioblastoma continuous cell cultures using fluorescent aptamers? by Moiseenko, V L, Antipova, O M, Pavlova, S A, Pronin, I N, Pavlova, G V, Kopylov, A M

“…Theranostics combines diagnostics and therapeutic exposure. Regarding glioblastomas, theranostics solves the problem of detecting and destroying tumor stem…”
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The power and limitations of influenza virus hemagglutinin assays by Ustinov, N. B., Zavyalova, E. G., Smirnova, I. G., Kopylov, A. M.

“…Influenza virus hemagglutinins (HAs) are surface proteins that bind to sialic acid residues at the host cell surface and ensure further virus internalization…”
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Covalently conjugated DNA aptamer with doxorubicin as in vitro model for effective targeted drug delivery to human glioblastoma tumor cells by Sliman, Ya A, Samoylenkova, N S, Antipova, O M, Brylev, V A, Veryutin, D A, Sapozhnikova, K A, Alekseeva, A I, Pronin, I N, Kopylov, A M, Pavlova, G V

“…Targeted delivery of chemotherapeutic agents with aptamers is a very effective method increasing therapeutic index compared to non-targeted drugs. To study the…”
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Effect of thrombin inhibitors on positive feedback in the coagulation cascade by Ustinov, N. B., Zav’yalova, E. G., Kopylov, A. M.

“…The coagulation cascade is a series of sequential reactions of limited proteolysis of protein factors resulting in generation of thrombin. Thrombin mediates…”
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DNA aptamers as radically new recognition elements for biosensors by Spiridonova, V A, Kopylov, A M

“…A fiber-optic biosensor based on DNA aptamers used as receptors was developed for the measurement of thrombin concentration. Anti-thrombin DNA aptamers were…”
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X-ray analysis of ribosomes: the static of the dynamic by Kopylov, A M

“…This review considers a brief history, comments, and consequences of recent remarkable achievements: X-ray analysis on the level of atomic resolution of…”
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Transcription analysis and small non-protein coding RNAs associated with bacterial ribosomal protein operons by Khayrullina, G A, Raabe, C A, Hoe, C H, Becker, K, Reinhardt, R, Tang, T H, Rozhdestvensky, T S, Kopylov, A M

“…For decades ribosome biogenesis and translation represent key targets in the antimicrobial drug development to combat bacterial infections. Here we report a…”
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Combinatorial Chemistry of Nucleic Acids: SELEX by Kopylov, A M, Spiridonova, V A

“…A method of irrational oligonucleotide design, SELEX, is considered. Individual SELEX products, aptamers, are small molecules (40-100 nt) that have a unique…”
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Coexistence of G-quadruplex and duplex domains within the secondary structure of 31-mer DNA thrombin-binding aptamer by Dolinnaya, N.G., Yuminova, A.V., Spiridonova, V.A., Arutyunyan, A.M., Kopylov, A.M.

“…A number of thrombin-binding DNA aptamers have been developed during recent years. So far the structure of just a single one, 15-mer thrombin-binding aptamer…”
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