Search Results - "Koppelman, Stef J"

The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds by Dreskin, Stephen C., Koppelman, Stef J., Andorf, Sandra, Nadeau, Kari C., Kalra, Anjeli, Braun, Werner, Negi, Surendra S., Chen, Xueni, Schein, Catherine H.

“…Allergies to peanuts, tree nuts, and sesame seeds are among the most important food-related causes of anaphylaxis. Important clinical questions include: Why is…”
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Comparison of recovery and immunochemical detection of peanut proteins from differentially roasted peanut flour using ELISA by Jayasena, Shyamali, Koppelman, Stef J., Nayak, Balunkeswar, Taylor, Steve L., Baumert, Joseph L.

“…•Most ELISA kits perform well in detecting peanut from minimally roasted peanut flours.•Most commercial peanut ELISAs are unable to quantify peanut in dark…”
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Chemically modified peanut extract shows increased safety while maintaining immunogenicity by Kleij, Hanneke P. M., Warmenhoven, Hans J. M., Ree, Ronald, Versteeg, Serge A., Pieters, Raymond H. H., Dreskin, Stephen C., Knulst, André C., Hoffen, Els, Opstelten, Dirk Jan E., Koppelman, Stef J., Smit, Joost J.

“…Background Peanuts are most responsible for food‐induced anaphylaxis in adults in developed countries. An effective and safe immunotherapy is urgently needed…”
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Allergenicity attributes of different peanut market types by Koppelman, Stef J., Jayasena, Shyamali, Luykx, Dion, Schepens, Erik, Apostolovic, Danijela, de Jong, Govardus A.H., Isleib, Thomas G., Nordlee, Julie, Baumert, Joe, Taylor, Steve L., Cheng, Hsiaopo, Maleki, Soheila

“…Four different market classes of peanut (Runner, Virginia Spanish, and Valencia) are commonly consumed in Western countries, but for some consumers peanuts are…”
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Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: A comparative in vitro study and partial characterization of digestion-resistant peptides by Koppelman, Stef J, Hefle, Sue L, Taylor, Steve L, de Jong, Govardus A.H

“…Scope: There are differences in stability to pepsin between the major allergens in peanut; however, data are from different reports using different digestion…”
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Dose and route of administration determine the efficacy of prophylactic immunotherapy for peanut allergy in a Brown Norway rat model by Sztuk, Tiffany Kirkaldy Spaanager, Rigby, Neil Marcus, Nørskov-Nielsen, Lasse, Koppelman, Stef J, Sancho, Ana Isabel, Knudsen, Niels-Peter Hell, Marsh, Justin, Johnson, Philip, Gupta, Shashank, Mackie, Alan Robert, Larsen, Jeppe Madura, Bøgh, Katrine Lindholm

“…Allergen-specific immunotherapy (IT) is emerging as a viable option for treatment of peanut allergy. Yet, prophylactic IT remains unexplored despite early…”
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Reduction and alkylation of peanut allergen isoforms Ara h 2 and Ara h 6; characterization of intermediate- and end products by Apostolovic, Danijela, Luykx, Dion, Warmenhoven, Hans, Verbart, Dennis, Stanic-Vucinic, Dragana, de Jong, Govardus A.H., Velickovic, Tanja Cirkovic, Koppelman, Stef J.

“…Conglutins, the major peanut allergens, Ara h 2 and Ara h 6, are highly structured proteins stabilized by multiple disulfide bridges and are stable towards…”
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Determination of Allergen Levels, Isoforms, and Their Hydroxyproline Modifications Among Peanut Genotypes by Mass Spectrometry by Marsh, Justin T., Palmer, Lee K., Koppelman, Stef J., Johnson, Philip E.

“…The recently published reference genome of peanuts enables a detailed molecular description of the allergenic proteins of the seed. We used LC-MS/MS to…”
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Ara h 6 Complements Ara h 2 as an Important Marker for IgE Reactivity to Peanut by Koid, Audrey E, Chapman, Martin D, Hamilton, Robert G, van Ree, Ronald, Versteeg, Serge A, Dreskin, Stephen C, Koppelman, Stef J, Wünschmann, Sabina

“…The similarities of two major peanut allergens, Ara h 2 and Ara h 6, in molecular size, amino acid sequence, and structure have made it difficult to obtain…”
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The importance of reducing risk in peanut allergy: Current and future therapies by Shreffler, Wayne G., Baumert, Joe L., Remington, Benjamin C., Koppelman, Stef J., Dinakar, Chitra, Fleischer, David M., Kim, Edwin, Tilles, Stephen A., Spergel, Jonathan M.

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Anaphylaxis from Passive Transfer of Peanut Allergen in a Blood Product by Koppelman, Stef J, Jacobs, Joannes F.M, Baumert, Joseph L, Brons, Paul P, van Pampus, Elisabeth C.M, Joosten, Irma

“…Anaphylactic transfusion reactions from passive transfer of IgE have been documented, but a case is now reported in which the eliciting factor was a food…”
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Peanut allergen Ara h 6 is detectable in blood transfusion products by Jansen, Fleur A. C., Norren, Klaske, Baumert, Joseph L., Bos, Annegeet, Jacobs, Joannes F. M., Koppelman, Stef J.

“…To the Editor, Peanut allergen Ara h 6 is known to maintain IgE-binding capacity upon exposure to digestive enzymes 1 and its presence in circulation after…”
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Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans by JanssenDuijghuijsen, Lonneke M, van Norren, Klaske, Grefte, Sander, Koppelman, Stef J, Lenaerts, Kaatje, Keijer, Jaap, Witkamp, Renger F, Wichers, Harry J

“…Controlled studies on the effect of exercise on intestinal uptake of protein are scarce and underlying mechanisms largely unclear. We studied the uptake of the…”
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Measuring parvalbumin levels in fish muscle tissue: Relevance of muscle locations and storage conditions by Lee, Poi-Wah, Nordlee, Julie A., Koppelman, Stef J., Baumert, Joseph L., Taylor, Steve L.

“…► Studied factors causing variable immunoreactivity of anti-parvalbumin antibodies. ► Antibody-reactive parvalbumin remained in fish muscle frozen for 4months…”
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Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible by Koppelman, Stef J, Smits, Mieke, Tomassen, Monic, de Jong, Govardus A H, Baumert, Joe, Taylor, Steve L, Witkamp, Renger, Veldman, Robert Jan, Pieters, Raymond, Wichers, Harry

“…The oral mucosa is the first immune tissue that encounters allergens upon ingestion of food. We hypothesized that the bio-accessibility of allergens at this…”
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Quantitative Assessment of the Safety Benefits Associated with Increasing Clinical Peanut Thresholds through Immunotherapy by Baumert, Joseph L., PhD, Martin, Laurent, PharmD, Thébault, Claude, MD, Taylor, Steve L., PhD, Koppelman, Stef J., PhD, Ruban, Charles, MSc

“…Methods SAS (version 9.2) was used to run quantitative (probabilistic) risk modeling to determine the percentage of individual eating occasions where a…”
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Development of a Germ-Free Murine Model for Prediction of Food Allergen Potency: Preliminary Studies Using Peanut Ara h1 and Ara h2 As Model Food Allergens by Marsteller, Nathan L., Dr, Andoh-Kumi, Kwame, MS, Koppelman, Stef J., Prof, Goodman, Richard E., Prof, Baumert, Joe L., Prof

“…A germ-free C3H/HeN mouse model for food allergy has shown promise for differentiating sensitization and elicitation profiles of known allergenic food proteins…”
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Evaluation and Comparison of the Species-Specificity of 3 Antiparvalbumin IgG Antibodies by Lee, Poi-Wah, Nordlee, Julie A, Koppelman, Stef J, Baumert, Joseph L, Taylor, Steve L

“…Parvalbumin is a pan-allergen in fish and frogs that triggers IgE-mediated reactions in fish-allergic individuals. Previous studies demonstrated that…”
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Sandwich Enzyme-Linked Immunosorbent Assay for Detecting Sesame Seed in Foods by Baumert, Joseph L., Gaskin, Ferdelie E., Niemann, Lynn, Söylemez, Gülsen, Koppelman, Stef J., Taylor, Steve L.

“…Small amounts of sesame can trigger allergic reactions in sesame-allergic patients. Because sesame is a widely used food ingredient, analytical methods are…”
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Controlling the aggregation propensity and thereby digestibility of allergens by Maillardation as illustrated for cod fish parvalbumin by de Jongh, Harmen H.J., Taylor, Steve L., Koppelman, Stef J.

“…The aggregation propensity of heat-treated codfish parvalbumin is investigated upon Maillardation of the protein under food-relevant conditions. About twelve…”
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