Search Results - "Koppel, Scott"

Neuroketotherapeutics: A modern review of a century-old therapy by Koppel, Scott J., Swerdlow, Russell H.

“…Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the induction of ketosis. These therapies include medium-chain…”
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Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism by Tan, Ee Phie, McGreal, Steven R., Graw, Stefan, Tessman, Robert, Koppel, Scott J., Dhakal, Pramod, Zhang, Zhen, Machacek, Miranda, Zachara, Natasha E., Koestler, Devin C., Peterson, Kenneth R., Thyfault, John P., Swerdlow, Russell H., Krishnamurthy, Partha, DiTacchio, Luciano, Apte, Udayan, Slawson, Chad

“…Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms…”
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A ketogenic diet differentially affects neuron and astrocyte transcription by Koppel, Scott J., Pei, Dong, Wilkins, Heather M., Weidling, Ian W., Wang, Xiaowan, Menta, Blaise W., Perez‐Ortiz, Judit, Kalani, Anuradha, Manley, Sharon, Novikova, Lesya, Koestler, Devin C., Swerdlow, Russell H.

“…Ketogenic diets (KDs) alter brain metabolism. Multiple mechanisms may account for their effects, and different brain regions may variably respond. Here, we…”
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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence by Koppel, Scott J., Wilkins, Heather M., Weidling, Ian W., Wang, Xiaowan, Menta, Blaise W., Swerdlow, Russell H.

“…•β-Hydroxybutyrate differentially impacts neuron and astrocyte mitochondria.•β-Hydroxybutyrate promotes neuron quiescence.•SH-SY5Y responses to…”
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Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients by Wilkins, Heather M, Koppel, Scott J, Bothwell, Rebecca, Mahnken, Jonathan, Burns, Jeffrey M, Swerdlow, Russell H

“…A degradation product of APOE ε4-encoded apolipoprotein E protein targets mitochondria and inhibits cytochrome oxidase (COX), and autopsy brains from young…”
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Bioenergetic and inflammatory systemic phenotypes in Alzheimer’s disease APOE ε4‐carriers by Wilkins, Heather M., Wang, Xiaowan, Menta, Blaise W., Koppel, Scott J., Bothwell, Rebecca, Becker, Annette M., Anderson, Heidi, Schwartz, Erin, Pei, Dong, Yellapu, Nanda K., Chalise, Prabhakar, Gouvion, Cynthia M., Haeri, Mohammad, Burns, Jeffrey M., Swerdlow, Russell H.

“…We examined the impact of an APOE ε4 genotype on Alzheimer's disease (AD) subject platelet and lymphocyte metabolism. Mean platelet mitochondrial cytochrome…”
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Mitochondrial DNA Manipulations Affect Tau Oligomerization by Weidling, Ian W, Wilkins, Heather M, Koppel, Scott J, Hutfles, Lewis, Wang, Xiaowan, Kalani, Anuradha, Menta, Blaise W, Ryan, Benjamin, Perez-Ortiz, Judit, Gamblin, T Chris, Swerdlow, Russell H

“…Mitochondrial dysfunction and tau aggregation occur in Alzheimer's disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. To…”
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Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis by Wilkins, Heather M, Harris, Janna L, Carl, Steven M, E, Lezi, Lu, Jianghua, Eva Selfridge, J, Roy, Nairita, Hutfles, Lewis, Koppel, Scott, Morris, Jill, Burns, Jeffrey M, Michaelis, Mary L, Michaelis, Elias K, Brooks, William M, Swerdlow, Russell H

“…Brain bioenergetic function declines in some neurodegenerative diseases, this may influence other pathologies and administering bioenergetic intermediates…”
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Effects of Microglial Cytokines on Alzheimer's Disease-Related Phenomena by Ji, Yan, Wang, Xiaowan, Kalicki, Colin, Menta, Blaise W, Baumgardner, Megan, Koppel, Scott J, Weidling, Ian W, Perez-Ortiz, Judit, Wilkins, Heather M, Swerdlow, Russell H

“…Recent association studies indicate several genes highly expressed by microglia influence Alzheimer's disease (AD) risk, which suggests microglial function…”
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Extracellular Mitochondria and Mitochondrial Components Act as Damage-Associated Molecular Pattern Molecules in the Mouse Brain by Wilkins, Heather M., Koppel, Scott J., Weidling, Ian W., Roy, Nairita, Ryan, Lauren N., Stanford, John A., Swerdlow, Russell H.

“…Mitochondria and mitochondrial debris are found in the brain’s extracellular space, and extracellular mitochondrial components can act as damage associated…”
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Astrocyte-secreted factors modulate a gradient of primary dendritic arbors in nucleus laminaris of the avian auditory brainstem by Korn, Matthew J, Koppel, Scott J, Cramer, Karina S

“…Neurons in nucleus laminaris (NL) receive binaural, tonotopically matched input from nucleus magnocelluaris (NM) onto bitufted dendrites that display a…”
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A bioenergetics systems evaluation of ketogenic diet liver effects by Hutfles, Lewis J, Wilkins, Heather M, Koppel, Scott J, Weidling, Ian W, Selfridge, J Eva, Tan, Eephie, Thyfault, John P, Slawson, Chad, Fenton, Aron W, Zhu, Hao, Swerdlow, Russell H

“…Ketogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To further evaluate how ketogenic diets affect hepatocyte bioenergetic…”
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Astrocyte-secreted factors modulate the developmental distribution of inhibitory synapses in nucleus laminaris of the avian auditory brainstem by Korn, Matthew J., Koppel, Scott J., Li, Lan H., Mehta, Divya, Mehta, Sonia B., Seidl, Armin H., Cramer, Karina S.

“…Nucleus laminaris (NL) neurons in the avian auditory brainstem are coincidence detectors necessary for the computation of interaural time differences used in…”
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Detection of mitochondria-pertinent components in exosomes by Wang, Xiaowan, Weidling, Ian, Koppel, Scott, Menta, Blaise, Perez Ortiz, Judit, Kalani, Anuradha, Wilkins, Heather M., Swerdlow, Russell H.

“…•Exosomes contain mitochondria-pertinent proteins.•Exosomes contain at least degraded authentic mtDNA.•Exosomes contain mtDNA-encoded mRNA. We screened cell…”
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Mitochondria, Cybrids, Aging, and Alzheimer's Disease by Swerdlow, R H, Koppel, S, Weidling, I, Hayley, C, Ji, Y, Wilkins, H M

“…Mitochondrial and bioenergetic function change with advancing age and may drive aging phenotypes. Mitochondrial and bioenergetic changes are also documented in…”
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Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure by Wilkins, Heather M., Koppel, Scott, Carl, Steven M., Ramanujan, Suruchi, Weidling, Ian, Michaelis, Mary L., Michaelis, Elias K., Swerdlow, Russell H.

“…We tested how the addition of oxaloacetate (OAA) to SH‐SY5Y cells affected bioenergetic fluxes and infrastructure, and compared the effects of OAA to malate,…”
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AMYLOID BETA AND BIOENERGETICS by Wilkins, Heather M., Menta, Blaise, Weidling, Ian, Koppel, Scott J., Swerdlow, Russell H.

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P1‐196: AMYLOID BETA AND BIOENERGETICS by Wilkins, Heather M., Menta, Blaise, Weidling, Ian, Koppel, Scott J., Swerdlow, Russell H.

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A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial by Wilkins, Heather M, Mahnken, Jonathan D, Welch, Paul, Bothwell, Rebecca, Koppel, Scott, Jackson, Richard L, Burns, Jeffrey M, Swerdlow, Russell H

“…Reductions in bioenergetic fluxes, mitochondrial enzyme activities, and mitochondrial number are observed in Alzheimer's disease (AD). Preclinical work…”
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Ninety‐day ketogenic diet intervention has differential effects on neuronal and astrocytic transcriptional pathways in mouse brain by Koppel, Scott J., Pei, Dong, Wilkins, Heather M., Weidling, Ian, Wang, Xiaowan, Menta, Blaise, Perez‐Ortiz, Judit, Kalani, Anuradha, Manley, Sharon, Koestler, Devin C., Swerdlow, Russell H.

“…Background Glucose hypometabolism and mitochondrial dysfunction are early deficits in Alzheimer’s disease (AD) brains. The ketogenic diet (KD) has been…”
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