Search Results - "Kopparapu, R"

Simulated Phase-dependent Spectra of Terrestrial Aquaplanets in M Dwarf Systems by Wolf, E. T., Kopparapu, R. K., Haqq-Misra, J.

“…Orbital phase-dependent variations in thermal emission and reflected stellar energy spectra can provide meaningful constraints on the climate states of…”
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Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC by Thomas, Portia L, Groves, Sarah M, Zhang, Yun-Kai, Li, Jia, Gonzalez-Ericsson, Paula, Sivagnanam, Shamilene, Betts, Courtney B, Chen, Hua-Chang, Liu, Qi, Lowe, Cindy, Chen, Heidi, Boyd, Kelli L, Kopparapu, Prasad R, Yan, Yingjun, Coussens, Lisa M, Quaranta, Vito, Tyson, Darren R, Iams, Wade, Lovly, Christine M

“…The programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors, atezolizumab and durvalumab, have received regulatory approval for the first-line treatment…”
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The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor by O'Donnell, Edmond F, Saili, Katerine S, Koch, Daniel C, Kopparapu, Prasad R, Farrer, David, Bisson, William H, Mathew, Lijoy K, Sengupta, Sumitra, Kerkvliet, Nancy I, Tanguay, Robert L, Kolluri, Siva Kumar

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related…”
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No evidence of phosphine in the atmosphere of Venus from independent analyses by Villanueva, G. L., Cordiner, M., Irwin, P. G. J., de Pater, I., Butler, B., Gurwell, M., Milam, S. N., Nixon, C. A., Luszcz-Cook, S. H., Wilson, C. F., Kofman, V., Liuzzi, G., Faggi, S., Fauchez, T. J., Lippi, M., Cosentino, R., Thelen, A. E., Moullet, A., Hartogh, P., Molter, E. M., Charnley, S., Arney, G. N., Mandell, A. M., Biver, N., Vandaele, A. C., de Kleer, K. R., Kopparapu, R.

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Blood-Based Surveillance Monitoring of Circulating Tumor DNA From Patients With SCLC Detects Disease Relapse and Predicts Death in Patients With Limited-Stage Disease by Iams, Wade T., Kopparapu, Prasad R., Yan, Yingjun, Muterspaugh, Anel, Zhao, Zhiguo, Chen, Heidi, Cann, Christopher, York, Sally, Horn, Leora, Ancell, Kristin, Wyman, Kenneth, Bertucci, Caterina, Shaffer, Tristan, Hodsdon, Lauren A., Garg, Kavita, Hosseini, Seyed Ali, Lim, Lee P., Lovly, Christine M.

“…Most patients (70%) with limited-stage SCLC (LS-SCLC) who are treated with curative-intent therapy suffer disease relapse and cancer-related death. We…”
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11‐Cl‐BBQ, a select modulator of AhR‐regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27Kip1 by Nguyen, Bach D., Stevens, Brenna L., Elson, Daniel J., Finlay, Darren, Gamble, John T., Kopparapu, Prasad R., Tanguay, Robyn L., Buermeyer, Andrew B., Kerkvliet, Nancy I., Kolluri, Siva K.

“…Aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor and functions as a tumour suppressor in different cancer models. In the present…”
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11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27 Kip1 by Nguyen, Bach D, Stevens, Brenna L, Elson, Daniel J, Finlay, Darren, Gamble, John T, Kopparapu, Prasad R, Tanguay, Robyn L, Buermeyer, Andrew B, Kerkvliet, Nancy I, Kolluri, Siva K

“…Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and functions as a tumour suppressor in different cancer models. In the present…”
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Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells by Pearce, Martin C, Gamble, John T, Kopparapu, Prasad R, O'Donnell, Edmond F, Mueller, Monica J, Jang, Hyo Sang, Greenwood, Julie A, Satterthwait, Arnold C, Tanguay, Robert L, Zhang, Xiao-Kun, Kolluri, Siva Kumar

“…Resistance to chemotherapy is a major cause of treatment failure and poor overall survival in patients with lung cancer. Identification of molecular targets…”
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Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1 by Koch, D C, Jang, H S, O'Donnell, E F, Punj, S, Kopparapu, P R, Bisson, W H, Kerkvliet, N I, Kolluri, S K

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the basic helix-loop-helix PER/ARNT/SIM family of chemosensors…”
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Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor- beta 1 by Koch, D C, Jang, H S, O'Donnell, E F, Punj, S, Kopparapu, P R, Bisson, W H, Kerkvliet, N I, Kolluri, S K

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the basic helix-loop-helix PER/ARNT/SIM family of chemosensors…”
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Small Molecule Functional Converter of B‑Cell Lymphoma‑2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis by Kopparapu, Prasad R., Löhr, Christiane V., Pearce, Martin C., Tyavanagimatt, Shanthakumar, Nakshatri, Harikrishna, Kolluri, Siva K.

“…The B-cell lymphoma-2 (Bcl-2) family of proteins plays a vital role in tumorigenesis. Cancer cells utilize the expression of Bcl-2 to evade therapy and develop…”
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Identification and Characterization of a Small Molecule Bcl-2 Functional Converter by Kopparapu, Prasad R, Pearce, Martin C, Löhr, Christiane V, Duong, Cathy, Jang, Hyo Sang, Tyavanagimatt, Shanthakumar, O'Donnell, 3rd, Edmond F, Nakshatri, Harikrishna, Kolluri, Siva K

“…Cancer cells exploit the expression of anti-apoptotic protein Bcl-2 to evade apoptosis and develop resistance to therapeutics. High levels of Bcl-2 leads to…”
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Simulated Phase-dependent Spectra of Terrestrial Aquaplanets in M Dwarf Systems by Wolf, E. T, Kopparapu, R. K, Haqq-Misra, J

“…THE Astrophysical Journal, 877:35 (18pp), 2019 May 20 Orbital phase-dependent variations in thermal emission and reflected stellar energy spectra can provide…”
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Large Interferometer For Exoplanets (LIFE): I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission by Quanz, S. P, Ottiger, M, Fontanet, E, Kammerer, J, Menti, F, Dannert, F, Gheorghe, A, Absil, O, Airapetian, V. S, Alei, E, Allart, R, Angerhausen, D, Blumenthal, S, Buchhave, L. A, Cabrera, J, Carrión-González, Ó, Chauvin, G, Danchi, W. C, Dandumont, C, Defrère, D, Dorn, C, Ehrenreich, D, Ertel, S, Fridlund, M, Muñoz, A. García, Gascón, C, Girard, J. H, Glauser, A, Grenfell, J. L, Guidi, G, Hagelberg, J, Helled, R, Ireland, M. J, Janson, M, Kopparapu, R. K, Korth, J, Kozakis, T, Kraus, S, Léger, A, Leedjärv, L, Lichtenberg, T, Lillo-Box, J, Linz, H, Liseau, R, Loicq, J, Mahendra, V, Malbet, F, Mathew, J, Mennesson, B, Meyer, M. R, Mishra, L, Molaverdikhani, K, Noack, L, Oza, A. V, Pallé, E, Parviainen, H, Quirrenbach, A, Rauer, H, Ribas, I, Rice, M, Romagnolo, A, Rugheimer, S, Schwieterman, E. W, Serabyn, E, Sharma, S, Stassun, K. G, Szulágyi, J, Wang, H. S, Wunderlich, F, Wyatt, M. C, collaboration, the LIFE

“…A&A 664, A21 (2022) One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand…”
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Reply to Shaw by Batalha, N.E., Kopparapu, R.K., Haqq-Misra, J., Kasting, J.F.

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Comparing ligo merger rate observations with theory: distribution of star-forming conditions by Belczynski, Kryzysztof, Kopparapu, R, O' Shaughnessy, R

“…Within the next decade, ground based gravitational wave detectors are in principle capable of determining the compact object merger rate per unit volume of the…”
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Population Boundaries for Galactic White Dwarf Binaries in LISA's Amplitude-Frequency Domain by Kopparapu, Ravi Kumar, Tohline, Joel E

“…Both detached, inspiraling and semidetached, mass-transferring double white dwarf (DWD) binary systems are expected to be important sources for the proposed…”
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TRAPPIST-1 Habitable Atmosphere Intercomparison (THAI): motivations and protocol version 1.0 by Fauchez, Thomas Jean Daniel, Turbet, Martin, Wolf, Eric T., Boutle, Ian, Way, Michael J., Genio, Anthony D. Del, Mayne, Nathan J., Tsigaridis, Konstantinos, Kopparapu, Ravi K., Yang, Jun, Forget, Francois, Mandell, Avi, Goldman, Shawn D. Domagal

“…Upcoming telescopes such as the James Webb Space Telescope (JWST), the European Extremely Large Telescope (E-ELT), the Thirty Meter Telescope (TMT) or the…”
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Abstract 3375: Molecular subtyping of circulating tumor cells in patients with small cell lung cancer by Kopparapu, Prasad R., Duplessis, Melinda, Lo, Edward, Yan, Yingjun, Iams, Wade T., Nordberg, Josh, Ramirez, Arturo, George, Tad, Lovly, Christine

“…Abstract Background: Recently, a new molecular classification of small cell lung cancer (SCLC), defined by expression of four key transcription regulators -…”
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Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-[beta]1 by Koch, D C, Jang, H S, O'donnell, E F, Punj, S, Kopparapu, P R, Bisson, W H, Kerkvliet, N I, Kolluri, S K

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the basic helix-loop-helix PER/ARNT/ SIM family of chemosensors…”
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