Search Results - "Kopp, Jeffrey"

Focal Segmental Glomerulosclerosis by Rosenberg, Avi Z, Kopp, Jeffrey B

“…Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with…”
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Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1 by Nichols, Brendan, Jog, Prachi, Lee, Jessica H, Blackler, Daniel, Wilmot, Michael, D'Agati, Vivette, Markowitz, Glen, Kopp, Jeffrey B, Alper, Seth L, Pollak, Martin R, Friedman, David J

“…Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African Americans. Here we report a cohort of patients who developed…”
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Phenotypes of APOL1 High-Risk Status Subjects by Kopp, Jeffrey B, Yoshida, Teruhiko

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APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD by Freedman, Barry I., Limou, Sophie, Ma, Lijun, Kopp, Jeffrey B.

“…Genetic methodologies are improving our understanding of the pathophysiology in diverse diseases. Breakthroughs have been particularly impressive in…”
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Genetics of Focal Segmental Glomerulosclerosis in African American Children by Levy, Rebecca, Kopp, Jeffrey B., Franceschini, Nora

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Global glomerulosclerosis in primary nephrotic syndrome: including age as a variable to predict renal outcomes by Kopp, Jeffrey B

“…With normal aging, there are increased numbers of globally sclerotic glomeruli. Global glomerulosclerosis is also a feature of chronic kidney disease. In this…”
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Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand by Ichii, Osamu, Otsuka-Kanazawa, Saori, Nakamura, Teppei, Ueno, Masaaki, Kon, Yasuhiro, Chen, Weiping, Rosenberg, Avi Z, Kopp, Jeffrey B

“…Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. Elevated serum indoxyl sulfate levels may…”
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Expanding the spectrum of APOL1-related renal disease: de novo collapsing glomerulopathy following kidney transplant by Kopp, Jeffrey B

“…Santoriello et al. report a series of 38 cases of de novo collapsing glomerulopathy following kidney transplant. Associations included acute rejection, viral…”
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Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder by Kopp, Jeffrey B

“…Hypertension is the attributed cause of approximately 30% of end-stage kidney disease cases in the United States, but there has been controversy as to whether…”
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COVID-19–Associated Collapsing Glomerulopathy: An Emerging Entity by Nasr, Samih H., Kopp, Jeffrey B.

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Banff Classification of Polyomavirus Nephropathy: A New Tool for Research and Clinical Practice by B Kopp, Jeffrey

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Disaster preparedness for patients with kidney disease by Kopp, Jeffrey B., Lempert, Kenneth, Finne, Kristen

“…Access to essential medical care can be compromised by social disruptions (such as riots and labour strikes), armed conflict and natural disasters, including…”
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Chronic Kidney Disease in the Aging Human Immunodeficiency Virus–Infected Population by Kopp, Jeffrey B.

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The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease by Curran, Colleen S, Kopp, Jeffrey B

“…Abstract Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may slow and occasionally halt CKD progression. CKD of diverse…”
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The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes by Tabei, Akifumi, Sakairi, Toru, Hamatani, Hiroko, Ohishi, Yuko, Watanabe, Mitsuharu, Nakasatomi, Masao, Ikeuchi, Hidekazu, Kaneko, Yoriaki, Kopp, Jeffrey B, Hiromura, Keiju

“…Transforming growth factor (TGF)-β1 contributes to podocyte injury in various glomerular diseases, including diabetic kidney disease, probably at least in part…”
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c-Src is in the effector pathway linking uPAR and podocyte injury by Kopp, Jeffrey B, Heymann, Jurgen

“…The role of urokinase-type plasminogen activator receptor (uPAR) in kidney physiology and pathology has attracted considerable attention. The protein uPAR has…”
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Podocytopathies by Kopp, Jeffrey B., Anders, Hans-Joachim, Susztak, Katalin, Podestà, Manuel A., Remuzzi, Giuseppe, Hildebrandt, Friedhelm, Romagnani, Paola

“…Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives proteinuria or nephrotic syndrome. In children and young adults, genetic…”
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Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice by Beckerman, Pazit, Bi-Karchin, Jing, Park, Ae Seo Deok, Qiu, Chengxiang, Dummer, Patrick D, Soomro, Irfana, Boustany-Kari, Carine M, Pullen, Steven S, Miner, Jeffrey H, Hu, Chien-An A, Rohacs, Tibor, Inoue, Kazunori, Ishibe, Shuta, Saleem, Moin A, Palmer, Matthew B, Cuervo, Ana Maria, Kopp, Jeffrey B, Susztak, Katalin

“…Risk variants of APOL1 associated with human chronic kidney disease have been identified, but causality has been unclear. Transgenic expression in mice now…”
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APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice by Ryu, Jung-Hwa, Ge, Mengyuan, Merscher, Sandra, Rosenberg, Avi Z, Desante, Marco, Roshanravan, Hila, Okamoto, Koji, Shin, Myung K, Hoek, Maarten, Fornoni, Alessia, Kopp, Jeffrey B

“…Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African…”
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The key role of NLRP3 and STING in APOL1-associated podocytopathy by Wu, Junnan, Raman, Archana, Coffey, Nathan J, Sheng, Xin, Wahba, Joseph, Seasock, Matthew J, Ma, Ziyuan, Beckerman, Pazit, Laczkó, Dorottya, Palmer, Matthew B, Kopp, Jeffrey B, Kuo, Jay J, Pullen, Steven S, Boustany-Kari, Carine M, Linkermann, Andreas, Susztak, Katalin

“…Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess kidney disease risk in African Americans; however, the molecular…”
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