Search Results - "Koplev, S"

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2) by Moore, Kathryn J, Koplev, Simon, Fisher, Edward A, Tabas, Ira, Björkegren, Johan L M, Doran, Amanda C, Kovacic, Jason C

“…Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages and…”
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Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching by Hartman, Robin J.G., Owsiany, Katie, Ma, Lijiang, Koplev, Simon, Hao, Ke, Slenders, Lotte, Civelek, Mete, Mokry, Michal, Kovacic, Jason C., Pasterkamp, Gerard, Owens, Gary, Björkegren, Johan L.M., den Ruijter, Hester M.

“…Although sex differences in coronary artery disease are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology…”
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Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype by Lecce, Laura, Xu, Yang, V'Gangula, Bhargavi, Chandel, Nirupama, Pothula, Venu, Caudrillier, Axelle, Santini, Maria Paola, d'Escamard, Valentina, Ceholski, Delaine K, Gorski, Przemek A, Ma, Lijiang, Koplev, Simon, Bjørklund, Martin Mæng, Björkegren, Johan Lm, Boehm, Manfred, Bentzon, Jacob Fog, Fuster, Valentin, Kim, Ha Won, Weintraub, Neal L, Baker, Andrew H, Bernstein, Emily, Kovacic, Jason C

“…Endothelial-mesenchymal transition (EndMT) is associated with various cardiovascular diseases and in particular with atherosclerosis and plaque instability…”
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Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade by Wang, Ying, Nanda, Vivek, Direnzo, Daniel, Ye, Jianqin, Xiao, Sophia, Kojima, Yoko, Howe, Kathryn L., Jarr, Kai-Uwe, Flores, Alyssa M., Tsantilas, Pavlos, Tsao, Noah, Rao, Abhiram, Newmane, Alexandra A. C., Eberhard, Anne V., Priest, James R., Ruusalepp, Arno, Pasterkamp, Gerard, Maegdefessel, Lars, Miller, Clint L., Lind, Lars, Koplev, Simon, Björkegren, Johan L. M., Owense, Gary K., Ingelsson, Erik, Weissmanr, Irving L., Leeper, Nicholas J.

“…Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that…”
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Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease by Zeng, Lingyao, Talukdar, Husain A., Koplev, Simon, Giannarelli, Chiara, Ivert, Torbjörn, Gan, Li-Ming, Ruusalepp, Arno, Schadt, Eric E., Kovacic, Jason C., Lusis, Aldons J., Michoel, Tom, Schunkert, Heribert, Björkegren, Johan L.M.

“…Genetic variants currently known to affect coronary artery disease (CAD) risk explain less than one-quarter of disease heritability. The heritability…”
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Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells by Wang, Ying, Gao, Hua, Wang, Fudi, Ye, Zhongde, Mokry, Michal, Turner, Adam W, Ye, Jianqin, Koplev, Simon, Luo, Lingfeng, Alsaigh, Tom, Adkar, Shaunak S, Elishaev, Maria, Gao, Xiangyu, Maegdefessel, Lars, Björkegren, Johan L M, Pasterkamp, Gerard, Miller, Clint L, Ross, Elsie G, Leeper, Nicholas J

“…De-differentiation and activation of pro-inflammatory pathways are key transitions vascular smooth muscle cells (SMCs) make during atherogenesis. Here, we…”
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Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes by Li, Ling, Chen, Zhifen, von Scheidt, Moritz, Li, Shuangyue, Steiner, Andrea, Güldener, Ulrich, Koplev, Simon, Ma, Angela, Hao, Ke, Pan, Calvin, Lusis, Aldons J., Pang, Shichao, Kessler, Thorsten, Ermel, Raili, Sukhavasi, Katyayani, Ruusalepp, Arno, Gagneur, Julien, Erdmann, Jeanette, Kovacic, Jason C., Björkegren, Johan L. M., Schunkert, Heribert

“…The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead,…”
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A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism by Seldin, Marcus M., Koplev, Simon, Rajbhandari, Prashant, Vergnes, Laurent, Rosenberg, Gregory M., Meng, Yonghong, Pan, Calvin, Phuong, Thuy M.N., Gharakhanian, Raffi, Che, Nam, Mäkinen, Selina, Shih, Diana M., Civelek, Mete, Parks, Brian W., Kim, Eric D., Norheim, Frode, Chella Krishnan, Karthickeyan, Hasin-Brumshtein, Yehudit, Mehrabian, Margarete, Laakso, Markku, Drevon, Christian A., Koistinen, Heikki A., Tontonoz, Peter, Reue, Karen, Cantor, Rita M., Björkegren, Johan L.M., Lusis, Aldons J.

“…Inter-tissue communication via secreted proteins has been established as a vital mechanism for proper physiologic homeostasis. Here, we report a bioinformatics…”
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JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells by Jones, Peter D, Kaiser, Michael A, Ghaderi Najafabadi, Maryam, Koplev, Simon, Zhao, Yuqi, Douglas, Gillian, Kyriakou, Theodosios, Andrews, Sarah, Rajmohan, Rathinasabapathy, Watkins, Hugh, Channon, Keith M, Ye, Shu, Yang, Xia, Björkegren, Johan L.M, Samani, Nilesh J, Webb, Tom R

“…OBJECTIVE—A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for…”
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Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes (vol 117, 6, 2022) by Li, L, Chen, Z, von, Scheidt M, Li, S, Steiner, A, Gueldener, U, Koplev, S, Ma, A, Hao, K, Pan, C

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Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus by Nanda, Vivek, Wang, Ting, Pjanic, Milos, Liu, Boxiang, Nguyen, Trieu, Matic, Ljubica Perisic, Hedin, Ulf, Koplev, Simon, Ma, Lijiang, Franzén, Oscar, Ruusalepp, Arno, Schadt, Eric E, Björkegren, Johan L M, Montgomery, Stephen B, Snyder, Michael P, Quertermous, Thomas, Leeper, Nicholas J, Miller, Clint L

“…Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial…”
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A mechanistic framework for cardiometabolic and coronary artery diseases by Koplev, Simon, Seldin, Marcus, Sukhavasi, Katyayani, Ermel, Raili, Pang, Shichao, Zeng, Lingyao, Bankier, Sean, Di Narzo, Antonio, Cheng, Haoxiang, Meda, Vamsidhar, Ma, Angela, Talukdar, Husain, Cohain, Ariella, Amadori, Letizia, Argmann, Carmen, Houten, Sander M, Franzén, Oscar, Mocci, Giuseppe, Meelu, Omar A, Ishikawa, Kiyotake, Whatling, Carl, Jain, Anamika, Jain, Rajeev Kumar, Gan, Li-Ming, Giannarelli, Chiara, Roussos, Panos, Hao, Ke, Schunkert, Heribert, Michoel, Tom, Ruusalepp, Arno, Schadt, Eric E, Kovacic, Jason C, Lusis, Aldon J, Björkegren, Johan L M

“…Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk factors, principally taking place in metabolic organs and the…”
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Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse by Kurt, Zeyneb, Cheng, Jenny, Barrere-Cain, Rio, McQuillen, Caden N, Saleem, Zara, Hsu, Neil, Jiang, Nuoya, Pan, Calvin, Franzén, Oscar, Koplev, Simon, Wang, Susanna, Björkegren, Johan, Lusis, Aldons J, Blencowe, Montgomery, Yang, Xia

“…Mouse models have been used extensively to study human coronary artery disease (CAD) or atherosclerosis and to test therapeutic targets. However, whether mouse…”
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Publisher Correction: Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes by Li, Ling, Chen, Zhifen, von Scheidt, Moritz, Li, Shuangyue, Steiner, Andrea, Güldener, Ulrich, Koplev, Simon, Ma, Angela, Hao, Ke, Pan, Calvin, Lusis, Aldons J., Pang, Shichao, Kessler, Thorsten, Ermel, Raili, Sukhavasi, Katyayani, Ruusalepp, Arno, Gagneur, Julien, Erdmann, Jeanette, Kovacic, Jason C., Björkegren, Johan L. M., Schunkert, Heribert

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Integrative Prioritization of Causal Genes for Coronary Artery Disease by Hao, Ke, Ermel, Raili, Sukhavasi, Katyayani, Cheng, Haoxiang, Ma, Lijiang, Li, Ling, Amadori, Letizia, Koplev, Simon, Franzén, Oscar, d’Escamard, Valentina, Chandel, Nirupama, Wolhuter, Kathryn, Bryce, Nicole S., Venkata, Vamsidhar R.M., Miller, Clint L., Ruusalepp, Arno, Schunkert, Heribert, Björkegren, Johan L.M., Kovacic, Jason C.

“…Hundreds of candidate genes have been associated with coronary artery disease (CAD) through genome-wide association studies. However, a systematic way to…”
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CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries by Michelis, Katherine C., Nomura-Kitabayashi, Aya, Lecce, Laura, Franzén, Oscar, Koplev, Simon, Xu, Yang, Santini, Maria Paola, D'Escamard, Valentina, Lee, Jonathan T.L., Fuster, Valentin, Hajjar, Roger, Reddy, Ramachandra C., Chikwe, Joanna, Stelzer, Paul, Filsoufi, Farzan, Stewart, Allan, Anyanwu, Anelechi, Björkegren, Johan L.M., Kovacic, Jason C.

“…Mesenchymal stem cells (MSCs) reportedly exist in a vascular niche occupying the outer adventitial layer. However, these cells have not been well characterized…”
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Abstract 185: Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Allows for Functional and Transcriptomic Insights Into Hereditary Dilated Cardiomyopathy Caused by Phospholamban Mutations by Ceholski, Delaine K, Turnbull, Irene C, Koplev, Simon, Kong, Chi-Wing, Stillitano, Francesca, Nonnenmacher, Mathieu, Haghighi, Kobra, Gorski, Przemyslaw A, Cohen, Ninette, Kolokathis, Fotis, Kremastinos, Dimitrios T, Babu, Arvind, Li, Ronald A, Giannarelli, Chiara, Karakikes, Ioannis, Kranias, Evangelia G, Costa, Kevin D, Hajjar, Roger J

“…Abstract only Dilated cardiomyopathy (DCM) can be caused by genetic mutations in numerous cardiac proteins, including phospholamban (PLN). PLN mutations are…”
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Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy by Frades, Itziar, Readhead, Ben, Amadori, Letizia, Koplev, Simon, Talukdar, Husain A, Crane, Heidi M, Crane, Paul K, Kovacic, Jason C, Dudley, Joel T, Giannarelli, Chiara, Björkegren, Johan L M, Peter, Inga

“…Antiretroviral therapy (ART) for HIV infection increases risk for coronary artery disease (CAD), presumably by causing dyslipidemia and increased…”
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High-power pulsed semiconductor lasers (905 nm) with an ultra-wide aperture (800 µm) based on epitaxially integrated triple heterostructures by Slipchenko, Sergey O., Podoskin, Alexander A., Gavrina, Polina S., Pikhtin, Nikita A., Koplev, Petr S., Bagaev, Timur A., Ladugin, Maxim A., Padalitsa, Anatoliy A., Marmalyuk, Alexander A.

“…Today, widening the aperture is considered as one of approaches in development of high-power pulsed semiconductor lasers [1] , [2] . Aperture widening…”
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Clonally-Expanding Smooth Muscle Cells Promote Atherosclerosis by Escaping From Efferocytosis and Activating the Complement Cascade by Wang, Y, Direnzo, D, Nanda, V, Ye, JQ, Xiao, S, Kojima, Y, Howe, KL, Jarr, KU, Flores, AM, Tsantilas, P, Tsao, N, Wirka, RC, Rao, A, Newman, A, Priest, J, Ruusalepp, A, Pasterkamp, G, Maegdefessel, L, Miller, C, Weissman, I, Lind, L, Koplev, S, Bjorkegren, JL, Owens, GK, Ingelsson, E, Leeper, NJ

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