Search Results - "Kopke, Richard"

HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma by Ewert, Donald, Hu, Ning, Du, Xiaoping, Li, Wei, West, Matthew B, Choi, Chul-Hee, Floyd, Robert, Kopke, Richard D

“…Oxidative stress is considered a major cause of the structural and functional changes associated with auditory pathologies induced by exposure to acute…”
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Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles by Youm, Ibrahima, West, Matthew B., Huang, Xiangping, Li, Wei, Kopke, Richard D.

“…The present study aimed to determine the effects of sucrose on the physical stability, cellular entry pathways and functional efficacy of…”
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Gene therapy for hair cell regeneration: Review and new data by Shibata, Seiji B., West, Matthew B., Du, Xiaoping, Iwasa, Yoichiro, Raphael, Yehoash, Kopke, Richard D.

“…Hair cells (HCs) in the cochlea are responsible for transducing mechanical sound energy into neural impulses which lead to the perception of sound. Loss of…”
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Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs by Du, Xiaoping, Cai, Qunfeng, West, Matthew B., Youm, Ibrahima, Huang, Xiangping, Li, Wei, Cheng, Weihua, Nakmali, Don, Ewert, Donald L., Kopke, Richard D.

“…Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously…”
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Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus by Lu, Jianzhong, West, Matthew B, Du, Xiaoping, Cai, Qunfeng, Ewert, Donald L, Cheng, Weihua, Nakmali, Don, Li, Wei, Huang, Xiangping, Kopke, Richard D

“…Tinnitus, the phantom perception of sound, often occurs as a clinical sequela of auditory traumas. In an effort to develop an objective test and therapeutic…”
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Effects of antioxidant treatment on blast-induced brain injury by Du, Xiaoping, Ewert, Donald L, Cheng, Weihua, West, Matthew B, Lu, Jianzhong, Li, Wei, Floyd, Robert A, Kopke, Richard D

“…Blast-induced traumatic brain injury has dramatically increased in combat troops in today's military operations. We previously reported that antioxidant…”
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Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure by Du, Xiaoping, West, Matthew B., Cai, Qunfeng, Cheng, Weihua, Ewert, Donald L., Li, Wei, Floyd, Robert A., Kopke, Richard D.

“…Cochlear neurodegeneration commonly accompanies hair cell loss resulting from aging, ototoxicity, or exposures to intense noise or blast overpressures…”
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siRNA-loaded biodegradable nanocarriers for therapeutic MAPK1 silencing against cisplatin-induced ototoxicity by Youm, Ibrahima, West, Matthew B., Li, Wei, Du, Xiaoping, Ewert, Donald L., Kopke, Richard D.

“…[Display omitted] Ototoxicity represents a major adverse side-effect of cis-diamminedichloroplatinum-II (cisplatin, CDDP). The mitogen-activated protein kinase…”
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Nitrones as therapeutics by Floyd, Robert A., Kopke, Richard D., Choi, Chul-Hee, Foster, Steven B., Doblas, Sabrina, Towner, Rheal A.

“…Nitrones have the general chemical formula X – CH = NO – Y. They were first used to trap free radicals in chemical systems and then subsequently in biochemical…”
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Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial by Kopke, Richard, Slade, Martin D., Jackson, Ronald, Hammill, Tanisha, Fausti, Stephen, Lonsbury-Martin, Brenda, Sanderson, Alicia, Dreisbach, Laura, Rabinowitz, Peter, Torre, Peter, Balough, Ben

“…Despite a robust hearing conservation program, military personnel continue to be at high risk for noise induced hearing loss (NIHL). For more than a decade, a…”
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Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA by Du, Xiaoping, Li, Wei, Gao, Xinsheng, West, Matthew B., Saltzman, W. Mark, Cheng, Christopher J., Stewart, Charles, Zheng, Jie, Cheng, Weihua, Kopke, Richard D.

“…The Notch pathway is a cell signaling pathway determining initial specification and subsequent cell fate in the inner ear. Previous studies have suggested that…”
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Antioxidants Reduce Cellular and Functional Changes Induced by Intense Noise in the Inner Ear and Cochlear Nucleus by Lu, Jianzhong, Li, Wei, Du, Xiaoping, Ewert, Donald L., West, Matthew B., Stewart, Charles, Floyd, Robert A., Kopke, Richard D

“…ABSTRACT The present study marks the first evaluation of combined application of the antioxidant N -acetylcysteine (NAC) and the free radical spin trap…”
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Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs by Du, Xiaoping, Chen, Kejian, Kuriyavar, Satish, Kopke, Richard D, Grady, Brian P, Bourne, David H, Li, Wei, Dormer, Kenneth J

“…Magnetically susceptible PLGA nanoparticles will effectively target the round window membrane (RWM) for delivery of dexamethasone-acetate (Dex-Ac) to the scala…”
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Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury by Kopke, Richard D., Floyd, Robert A., Saunders, Debra, Li, Wei, Ewert, Donald L., Cheng, Weihua, West, Matthew B., Du, Xiaoping, Towner, Rheal A.

“…Traumatic brain injury (TBI) can lead to early onset dementia and other related neurodegenerative diseases. We previously demonstrated that damage to the…”
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NAC for noise: From the bench top to the clinic by Kopke, Richard D., Jackson, Ronald L., Coleman, John K.M., Liu, Jianzhong, Bielefeld, Eric C., Balough, Ben J.

“…Noise-induced hearing loss (NIHL) is an important etiology of deafness worldwide. Hearing conservation programs are in place and have reduced the prevalence of…”
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Dispersion of super paramagnetic iron oxide nanoparticles in poly( d, l-lactide-co-glycolide) microparticles by Wassel, Ronald A., Grady, Brian, Kopke, Richard D., Dormer, Kenneth J.

“…Superparamagnetic iron oxide nanoparticles (SPIONs) coated with oleic acid were encapsulated into poly( d, l-lactide-co-glycolide) (PLGA) particles using an…”
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Demonstration of Functional Coupling between γ-Aminobutyric Acid (GABA) Synthesis and Vesicular GABA Transport into Synaptic Vesicles by Jin, Hong, Wu, Heng, Osterhaus, Gregory, Wei, Jianning, Davis, Kathleen, Sha, Di, Floor, Eric, Hsu, Che-Chang, Kopke, Richard D., Wu, Jang-Yen

“…L-Glutamic acid decarboxylase (GAD) exists as both membrane-associated and soluble forms in the mammalian brain. Here, we propose that there is a functional…”
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Low-Dose D-Methionine and N-Acetyl-L-Cysteine for Protection from Permanent Noise-Induced Hearing Loss in Chinchillas by Clifford, Royce E., Coleman, John K. M., Balough, Ben J., Liu, Jianzhong, Kopke, Richard D., Jackson, Ronald L.

“…Objective. Despite efforts at public health awareness and stringent industrial standards for hearing protection, noise-induced hearing loss (NIHL) remains a…”
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Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment by Du, Xiaoping, Chen, Kejian, Choi, Chul-Hee, Li, Wei, Cheng, Weihua, Stewart, Charles, Hu, Ning, Floyd, Robert A., Kopke, Richard D.

“…The purpose of this study was to reveal synaptic plasticity within the dorsal cochlear nucleus (DCN) as a result of noise trauma and to determine whether…”
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Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla by Choi, Chul-Hee, Chen, Kejian, Vasquez-Weldon, Angelica, Jackson, Ronald L., Floyd, Robert A., Kopke, Richard D.

“…Acute acoustic trauma (AAT) results in oxidative stress to the cochlea through overproduction of cellular reactive oxygen, nitrogen, and other free radical…”
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