Very low magnesium levels in red blood cells as a significant factor in the etiopathogenesis of borderline disorders

Basic studies indicate magnesium deficiency as one of the important, but often neglected, risk factors aggravating the course of borderline disorders (BD). A clinical verification of this notion has been conducted. Authors studied 62 patients with BD, aged 25-65 years, of inpatient and outpatient se...

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Bibliographic Details
Published in:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 115; no. 11; p. 85
Main Authors:	Kopitsyna, U E, Grishina, T R, Torshin, I Yu, Kalacheva, A G, Gromova, O A
Format:	Journal Article
Language:	English Russian
Published:	Russia (Federation) 2015
Subjects:	Adult Aged Anxiety - blood Anxiety - drug therapy Anxiety - metabolism Ascorbic Acid - administration & dosage Depression - blood Depression - drug therapy Depression - metabolism Erythrocytes - chemistry Female Humans Magnesium - administration & dosage Magnesium - blood Magnesium Deficiency - blood Magnesium Deficiency - drug therapy Magnesium Deficiency - metabolism Male Middle Aged Personality Disorders - blood Personality Disorders - drug therapy Personality Disorders - metabolism Sleep - drug effects Vitamin B 6 - administration & dosage
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Summary:	Basic studies indicate magnesium deficiency as one of the important, but often neglected, risk factors aggravating the course of borderline disorders (BD). A clinical verification of this notion has been conducted. Authors studied 62 patients with BD, aged 25-65 years, of inpatient and outpatient settings. Contents of magnesium and other blood electrolytes were determined. Authors found an extremely high prevalence of very low levels of magnesium (Mg) in erythrocytes (<0.3 mmol/l) in patients with BD compared to controls (patients without BD, Mg (er.) 1.62±0.48 mmol/l). It has been shown that low Mg levels in the plasma and red blood cells are associated with a significantly increased risk of the following diagnoses: F07 «Personality and behavioral disorder due to brain disease, damage and dysfunction» (p<0.0016), F21 «Schizotypal disorder» (p<0.0005) and F34 «Persistent mood [affective] disorders» (p<0.0001). The use of Magne B6 Forte (4 tablets/day, 30 days, then 2 tablets/day for 1 year) resulted in a significant increase in the Mg levels in the plasma and erythrocytes, the compensation of anxiety and depressive symptoms, improvement of sleep and general health of the patients, reduced consumption of antidepressants (by 30%). Administration of the drugs based on organic salts of magnesium per os improves the condition of patients and reduces their need in pharmacotherapy.
ISSN:	1997-7298
DOI:	10.17116/jnevro201511511185-96