Search Results - "Kopin, I J"

The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain by Herzberg, U, Eliav, E, Bennett, G.J, Kopin, Irwin J

“…The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a…”
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Catechols in post-mortem brain of patients with Parkinson disease by Goldstein, D. S., Sullivan, P., Holmes, C., Kopin, I. J., Basile, M. J., Mash, D. C.

“…Background:  Dihydroxyphenylacetaldehyde (DOPAL), a cytotoxic metabolite of dopamine, is the focus of the ‘catecholaldehyde hypothesis’ about the pathogenesis…”
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Sympathetic Cardioneuropathy in Dysautonomias by Goldstein, David S, Holmes, Courtney, Cannon, Richard O, Eisenhofer, Graeme, Kopin, Irwin J

“…Dysautonomias, derangements of sympathetic or parasympathetic nervous system function, are seen fairly often in neurology and cardiology. Autonomic…”
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Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells by Goldstein, David S, Jinsmaa, Yunden, Sullivan, Patti, Holmes, Courtney, Kopin, Irwin J, Sharabi, Yehonatan

“…According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal…”
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Cardiac sympathetic nerve function in congestive heart failure by EISENHOFER, G, FRIBERG, P, RUNDQVIST, B, QUYYUMI, A. A, LAMBERT, G, KAYE, D. M, KOPIN, I. J, GOLDSTEIN, D. S, ESLER, M. D

“…Increased availability of norepinephrine (NE) for activation of cardiac adrenoceptors (increased cardiac adrenergic drive) and depletion of myocardial NE…”
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3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells by Lamensdorf, Itschak, Eisenhofer, Graeme, Harvey-White, Judith, Nechustan, Amotz, Kirk, Kenneth, Kopin, Irwin J.

“…3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a toxic metabolite formed by the oxidative deamination of dopamine. This aldehyde is mainly oxidized to…”
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Catecholamine metabolism: basic aspects and clinical significance by Kopin, I J

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Endogenous serotonin stimulates striatal dopamine release in conscious rats by Yadid, G, Pacak, K, Kopin, I J, Goldstein, D S

“…Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased…”
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Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde by Lamensdorf, I., Eisenhofer, G., Harvey-White, J., Hayakawa, Y., Kirk, K., Kopin, I.J.

“…3,4‐Dihydroxyphenylacetaldehyde (DOPAL) has been reported to be a toxic metabolite formed by the oxidative‐deamination of dopamine (DA) catalyzed by monoamine…”
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MPTP toxicity: implications for research in Parkinson's disease by Kopin, I J, Markey, S P

“…In summary, the parkinsonism induced by MPTP in man closely resembles time-telescoped Parkinson's disease. Parkinsonian symptoms can be duplicated in all…”
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Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase by Eisenhofer, G, Goldstein, D S, Stull, R, Keiser, H R, Sunderland, T, Murphy, D L, Kopin, I J

“…This is a reversed-phase liquid-chromatographic method, with electrochemical detection, for simultaneously measuring, in plasma, the concentrations of the…”
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Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats by Kvetnanský, R, Fukuhara, K, Pacák, K, Cizza, G, Goldstein, D S, Kopin, I J

“…Cardiovascular and metabolic adjustments during stress involve participation of the sympatho-adrenal and hypothalamic-pituitary-adrenocortical systems, which…”
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Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of alpha-synuclein by Goldstein, D S, Li, S T, Kopin, I J

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A Primate Model of Parkinsonism: Selective Destruction of Dopaminergic Neurons in the Pars Compacta of the Substantia Nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Burns, R. Stanley, Chiueh, Chuang C., Markey, Sanford P., Ebert, Michael H., Jacobowitz, David M., Kopin, Irwin J.

“…A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which…”
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Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes by Lenders, J W, Eisenhofer, G, Abeling, N G, Berger, W, Murphy, D L, Konings, C H, Wagemakers, L M, Kopin, I J, Karoum, F, van Gennip, A H, Brunner, H G

“…Monoamine oxidase (MAO) exists as two isoenzymes and plays a central role in the metabolism of monoamine neurotransmitters. In this study we compared the…”
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Determination of metanephrines in plasma by liquid chromatography with electrochemical detection by Lenders, J W, Eisenhofer, G, Armando, I, Keiser, H R, Goldstein, D S, Kopin, I J

“…Metanephrines are O-methylated metabolites of catecholamines. We report the use of liquid chromatography with electrochemical detection to determine plasma…”
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Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans by GOLDSTEIN, D. S, EISENHOFER, G, STULL, R, FOLIO, C. J, KEISER, H. R, KOPIN, I. J

“…We examined plasma levels of the sympathetic neurotransmitter norepinephrine (NE) and its deaminated metabolite dihydroxyphenylglycol (DHPG) during supine rest…”
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Effects of immobilization on in vivo release of norepinephrine in the bed nucleus of the stria terminalis in conscious rats by Pacak, Karel, McCarty, Richard, Palkovits, Miklos, Kopin, Irwin J., Goldstein, David S.

“…Release of norepinephrine (NE) and its metabolites in the bed nucleus of the stria terminalis (BNST) was examined using in vivo microdialysis in conscious rats…”
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Induction of Tyrosine Hydroxylase Gene Expression by a Nonneuronal Nonpituitary-Mediated Mechanism in Immobilization Stress by Nankova, Bistra, Kvetnansky, Richard, McMahon, Anne, Viskupic, Emil, Hiremagalur, Bhargava, Frankle, Gordon, Fukuhara, Koki, Kopin, Irwin J., Sabban, Esther L.

“…Stress stimulates the sympathoadrenal system, causing activation of the catecholamine biosynthetic enzymes. Here we examine the changes of gene expression of…”
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Structural properties of phenylethylamine derivatives which inhibit transport‐P in peptidergic neurones by Al‐Damluji, S, Kopin, I J

“…Transport‐P is an antidepressant‐sensitive, proton‐dependent, V‐ATPase‐linked uptake process for amines in peptidergic neurones of the hypothalamus. It is…”
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