Search Results - "Koper, JW"

Glucocorticoid sensitivity in health and disease by Quax, Rogier A., Manenschijn, Laura, Koper, Jan W., Hazes, Johanna M., Lamberts, Steven W. J., van Rossum, Elisabeth F. C., Feelders, Richard A.

“…Glucocorticoids are involved in the regulation of many physiological processes and are essential to the systemic response to stress. This Review outlines…”
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Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression by van Rossum, Elisabeth F.C., Binder, Elisabeth B., Majer, Matthias, Koper, Jan W., Ising, Marcus, Modell, Sieglinde, Salyakina, Daria, Lamberts, Steven W.J., Holsboer, Florian

“…The most consistent biological finding in patients with depression is a hyperactivity of the hypothalamic–pituitary–adrenal (HPA)-axis, which might be caused…”
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Common Polymorphisms in the Glucocorticoid Receptor Gene Are Associated with Adrenocortical Responses to Psychosocial Stress by Wüst, Stefan, van Rossum, Elisabeth F. C., Federenko, Ilona S., Koper, Jan W., Kumsta, Robert, Hellhammer, Dirk H.

“…Chronic dysregulation of hypothalamus-pituitary-adrenal axis activity is related to several stress-related disorders. Evidence suggests that polymorphisms in…”
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Elevated hair cortisol concentrations in children with adrenal insufficiency on hydrocortisone replacement therapy by Noppe, G., van Rossum, E.F.C., Vliegenthart, J., Koper, J.W., van den Akker, E.L.T.

“…Summary Background Glucocorticoid replacement therapy in patients with adrenal insufficiency needs to be tailored to the individual patient based on body…”
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Two Polymorphisms in the Glucocorticoid Receptor Gene Directly Affect Glucocorticoid-Regulated Gene Expression by Russcher, Henk, Smit, Pauline, van den Akker, Erica L. T., van Rossum, Elisabeth F. C., Brinkmann, Albert O., de Jong, Frank H., Lamberts, Steven W. J., Koper, Jan W.

“…Context: Interindividual variation in glucocorticoid (GC)-sensitivity can be partly explained by polymorphisms in the GC receptor (GR) gene. The ER22/23EK and…”
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Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index by Van Rossum, Elisabeth F. C., Koper, Jan W., Van Den Beld, Annewieke W., Uitterlinden, André G., Arp, Pascal, Ester, Wietske, Janssen, Joop A. M. J. L., Brinkmann, Albert O., De Jong, Frank H., Grobbee, Diederick E., Pols, Huibert A. P., J. Lamberts, Steven W.

“…Summary objective  Sensitivity to glucocorticoids differs between individuals, partially due to genetic variation in the glucocorticoid receptor (GR) gene. We…”
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The ER22/23EK Polymorphism in the Glucocorticoid Receptor Gene Is Associated with a Beneficial Body Composition and Muscle Strength in Young Adults by van Rossum, Elisabeth F. C., Voorhoeve, Paul G., te Velde, Saskia J., Koper, Jan W., Delemarre-van de Waal, Henriette A., Kemper, Han C. G., Lamberts, Steven W. J.

“…Glucocorticoids play an important role in determining body composition. A polymorphism of the glucocorticoid receptor gene (in codons 22 and 23) has previously…”
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Increased Expression of the Glucocorticoid Receptor-A Translational Isoform as a Result of the ER22/23EK Polymorphism by Russcher, Henk, van Rossum, Elisabeth F. C, de Jong, Frank H, Brinkmann, Albert O, Lamberts, Steven W. J, Koper, Jan W

“…One of the most intriguing polymorphisms in the GR [glucocorticoid (GC) receptor] gene is in codons 22 and 23 [GAGAGG(GluArg) → GAAAAG (GluLys)]. This…”
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A Psychobiological Perspective on Genetic Determinants of Hypothalamus-Pituitary-Adrenal Axis Activity by WÜST, STEFAN, FEDERENKO, ILONA S., van ROSSUM, ELISABETH F.C., KOPER, JAN W., KUMSTA, ROBERT, ENTRINGER, SONJA, HELLHAMMER, DIRK H.

“…: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the…”
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A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo by HUIZENGA, N. A. T. M, KOPER, J. W, DE LANGE, P, POLS, H. A. P, STOLK, R. P, BURGER, H, GROBBEE, D. E, BRINKMANN, A. O, DE JONG, F. H, LAMBERTS, S. W. J

“…We investigated whether a polymorphism at nucleotide position 1220, resulting in an asparagine-to-serine change at codon 363 in the glucocorticoid receptor…”
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The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients by Di Blasio, Anna Maria, Van Rossum, Elisabeth F. C., Maestrini, Sabrina, Berselli, Maria Elisa, Tagliaferri, Mariantonella, Podestà, Francesca, Koper, Jan W., Liuzzi, Antonio, Lamberts, Steven W. J.

“…Summary objective  We have recently reported that, in healthy elderly Dutch individuals, a N363S polymorphism in the glucocorticoid receptor (GR) gene is…”
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Differential Inhibition of 17α-Hydroxylase and 17,20-Lyase Activities by Three Novel Missense CYP17 Mutations Identified in Patients with P450c17 Deficiency by van den Akker, Erica L. T., Koper, Jan W., Boehmer, Annemie L. M., Themmen, Axel P. N., Verhoef-Post, Miriam, Timmerman, Marianna A., Otten, Barto J., Drop, Stenvert L. S., De Jong, Frank H.

“…The microsomal enzyme cytochrome P450c17 is an important regulator of steroidogenesis. The enzyme has two functions: 17α-hydroxylase and 17,20-lyase…”
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Genetic Variations in the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia by TISSING, Wim J. E, MEIJERINK, Jules P. P, DEN BOER, Monique L, BRINKHOF, Bas, VAN ROSSUM, Elisabeth F. C, VAN WERING, Elisabeth R, KOPER, Jan W, SONNEVELD, Pieter, PIETERS, Rob

“…Glucocorticoid sensitivity is an important prognostic factor in pediatric acute lymphoblastic leukemia (ALL). For its antileukemic effect, glucocorticoid binds…”
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Expression of the Human Glucocorticoid Receptor Splice Variants α, β, and P in Peripheral Blood Mononuclear Leukocytes in Healthy Controls and in Patients with Hyper- and Hypocortisolism by Hagendorf, Antje, Koper, Jan W., de Jong, Frank H., Brinkmann, Albert O., Lamberts, Steven W. J., Feelders, Richard A.

“…Context: The effects of cortisol are mediated by the α-isoform of the glucocorticoid receptor (GR). GR-α levels and activity are modulated by alternative…”
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In vitro glucocorticoid sensitivity is associated with clinical glucocorticoid therapy outcome in rheumatoid arthritis by Quax, Rogier A M, Koper, Jan W, de Jong, Pascal H P, van Heerebeek, Ramona, Weel, Angelique E, Huisman, Anne M, van Zeben, Derkjen, de Jong, Frank H, Lamberts, Steven W J, Hazes, Johanna M W, Feelders, Richard A

“…Genetic and disease-related factors give rise to a wide spectrum of glucocorticoid (GC) sensitivity in rheumatoid arthritis (RA). In clinical practice, GC…”
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Differential Regulation of Synthetic Glucocorticoids on Gene Expression Levels of Glucocorticoid-Induced Leucine Zipper and Interleukin-2 by Smit, Pauline, Russcher, Henk, de Jong, Frank H., Brinkmann, Albert O., Lamberts, Steven W. J., Koper, Jan W.

“…Individual glucocorticoid (GC) sensitivity was determined by measuring the effects of several clinically used GCs on transactivation of the GC-induced leucine…”
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Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals by HUIZENGA, N. A. T. M, KOPER, J. W, DE LANGE, P, POLS, H. A. P, STOLK, R. P, GROBBEE, D. E, DE JONG, F. H, LAMBERTS, S. W. J

“…In the present study, we investigated whether the negative feedback action of glucocorticoids (GCs) on the hypothalamo-pituitary-adrenal (HPA) axis changes…”
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Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men by van Rossum, Elisabeth F C, Feelders, Richard A, van den Beld, Annewieke W, Uitterlinden, André G, Janssen, Joop A M J L, Ester, Wietske, Brinkmann, Albert O, Grobbee, Diederick E, de Jong, Frank H, Pols, Huibert A P, Koper, Jan W, Lamberts, Steven W J

“…We recently demonstrated that a polymorphism in codons 22 and 23 of the glucocorticoid receptor gene is associated with relative glucocorticoid resistance,…”
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Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells by DE LANGE, Pieter, SEGEREN, Christine M, KOPER, Jan W, WIEMER, Erik, SONNEVELD, Pieter, BRINKMANN, Albert O, WHITE, Anne, BROGAN, Iain J, DE JONG, Frank H, LAMBERTS, Steven W. J

“…Glucocorticoids play an important role in the treatment of a number of hematological malignancies, such as multiple myeloma. The effects of glucocorticoids are…”
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A Common Polymorphism in the CYP3A7 Gene Is Associated with a Nearly 50% Reduction in Serum Dehydroepiandrosterone Sulfate Levels by Smit, Pauline, van Schaik, Ron H. N., van der Werf, Marloes, van den Beld, Annewieke W., Koper, Jan W., Lindemans, Jan, Pols, Huibert A. P., Brinkmann, Albert O., de Jong, Frank H., Lamberts, Steven W. J.

“…Context: CYP3A7, expressed in the human fetal liver and normally silenced after birth, plays a major role in the 16α-hydroxylation of dehydroepiandrosterone…”
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