Search Results - "Kopec, Anna K."

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans by Groeneveld, Dafna, Pereyra, David, Veldhuis, Zwanida, Adelmeijer, Jelle, Ottens, Petra, Kopec, Anna K., Starlinger, Patrick, Lisman, Ton, Luyendyk, James P.

“…Platelets play a pivotal role in stimulating liver regeneration after partial hepatectomy in rodents and humans. Liver regeneration in rodents is delayed when…”
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Thrombin promotes diet-induced obesity through fibrin-driven inflammation by Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J

“…Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several…”
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A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice by Miszta, Adam, Kopec, Anna K., Pant, Asmita, Holle, Lori A., Byrnes, James R., Lawrence, Daniel A., Hansen, Kirk C., Flick, Matthew J., Luyendyk, James P., de Laat, Bas, Wolberg, Alisa S.

“…Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and…”
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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact by Kopec, Anna K., Yokokawa, Ryuji, Khan, Nasir, Horii, Ikuo, Finley, James E., Bono, Christine P., Donovan, Carol, Roy, Jessica, Harney, Julie, Burdick, Andrew D., Jessen, Bart, Lu, Shuyan, Collinge, Mark, Sadeghian, Ramin Banan, Derzi, Mazin, Tomlinson, Lindsay, Burkhardt, John E.

“…Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living…”
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Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury by Rautou, Pierre-Emmanuel, Tatsumi, Kohei, Antoniak, Silvio, Owens, A. Phillip, Sparkenbaugh, Erica, Holle, Lori A, Wolberg, Alisa S, Kopec, Anna K, Pawlinski, Rafal, Luyendyk, James P, Mackman, Nigel

“…Background & Aims Patients with chronic liver disease and cirrhosis have a dysregulated coagulation system and are prone to thrombosis. The basis for this…”
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Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse by Bates, Melissa A, Akbari, Peyman, Gilley, Kristen N, Wagner, James G, Li, Ning, Kopec, Anna K, Wierenga, Kathryn A, Jackson-Humbles, Daven, Brandenberger, Christina, Holian, Andrij, Benninghoff, Abby D, Harkema, Jack R, Pestka, James J

“…Ectopic lymphoid structures (ELS) consist of B-cell and T-cell aggregates that are initiated in inflamed tissues outside of secondary lymphoid organs. When…”
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Hepatocyte tissue factor activates the coagulation cascade in mice by Sullivan, Bradley P., Kopec, Anna K., Joshi, Nikita, Cline, Holly, Brown, Juliette A., Bishop, Stephanie C., Kassel, Karen M., Rockwell, Cheryl, Mackman, Nigel, Luyendyk, James P.

“…In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs) and evaluated its role in mouse models of HPC transplantation and…”
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Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium by Thompson, Chad M, Proctor, Deborah M, Haws, Laurie C, Hébert, Charles D, Grimes, Sheila D, Shertzer, Howard G, Kopec, Anna K, Hixon, J Gregory, Zacharewski, Timothy R, Harris, Mark A

“…Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To investigate the mode of action…”
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The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury by Joshi, Nikita, Kopec, Anna K, Towery, Keara, Williams, Kurt J, Luyendyk, James P

“…Hepatic fibrin deposition has been shown to inhibit hepatocellular injury in mice exposed to the bile duct toxicant α-naphthylisothiocyanate (ANIT)…”
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Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water by KOPEC, Anna K, KIM, Suntae, FORGACS, Agnes L, ZACHAREWSKI, Timothy R, PROCTOR, Deborah M, HARRIS, Mark A, HAWS, Laurie C, THOMPSON, Chad M

“…Chronic administration of high doses of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) elicits alimentary cancers in mice. To further…”
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Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice by Kopec, Anna K, Boverhof, Darrell R, Nault, Rance, Harkema, Jack R, Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Chittim, Brock, Zacharewski, Timothy R

“…Acute exposure to hepatotoxic doses of 2,3,7,8-tetrachloro- dibenzo-p-dioxin (TCDD) in mice is characterized by differential gene expression that can be…”
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Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice by Kopec, Anna K., Burgoon, Lyle D., Ibrahim-Aibo, Daher, Burg, Ashley R., Lee, Andrea W., Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Harkema, Jack R., Rowlands, J. Craig, Budinsky, Robert A., Zacharewski, Timothy R.

“…The toxic equivalency factor (TEF) approach recommended by the World Health Organization is used to quantify dioxin-like exposure concentrations for mixtures…”
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Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice by Saini, Yogesh, Proper, Steven P, Dornbos, Peter, Greenwood, Krista K, Kopec, Anna K, Lynn, Scott G, Grier, Elizabeth, Burgoon, Lyle D, Zacharewski, Timothy R, Thomas, Russell S, Harkema, Jack R, LaPres, John J

“…Hypoxia is a state of decreased oxygen reaching the tissues of the body. During prenatal development, the fetus experiences localized occurrences of hypoxia…”
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Role of the blood coagulation cascade in hepatic fibrosis by Pant, Asmita, Kopec, Anna K, Luyendyk, James P

“…Liver is the primary source of numerous proteins that are critical for normal function of the blood coagulation cascade. Because of this, diseases of the…”
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PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands by Kopec, Anna K., Burgoon, Lyle D., Ibrahim-Aibo, Daher, Mets, Bryan D., Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Harkema, Jack R., Zacharewski, Timothy R.

“…Polychlorinated biphenyls (PCBs) are ubiquitous contaminants found as complex mixtures of coplanar and non-coplanar congeners. The hepatic temporal and…”
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Towards in vitro models for reducing or replacing the use of animals in drug testing by Stresser, David M, Kopec, Anna K, Hewitt, Philip, Hardwick, Rhiannon N, Van Vleet, Terry R, Mahalingaiah, Prathap Kumar S, O'Connell, Denice, Jenkins, Gary J, David, Rhiannon, Graham, Jessica, Lee, Donna, Ekert, Jason, Fullerton, Aaron, Villenave, Remi, Bajaj, Piyush, Gosset, James R, Ralston, Sherry L, Guha, Manti, Amador-Arjona, Alejandro, Khan, Kainat, Agarwal, Saket, Hasselgren, Catrin, Wang, Xiaoting, Adams, Khary, Kaushik, Gaurav, Raczynski, Arkadiusz, Homan, Kimberly A

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Cross‐linking by tissue transglutaminase‐2 alters fibrinogen‐directed macrophage proinflammatory activity by Poole, Lauren G., Kopec, Anna K., Flick, Matthew J., Luyendyk, James P.

“…Background The blood coagulation factor fibrin(ogen) can modulate inflammation by altering leukocyte activity. Analyses of fibrin(ogen)‐mediated…”
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Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αM β2 integrin-dependent upregulation of Mmp12 by Kopec, Anna K, Joshi, Nikita, Cline-Fedewa, Holly, Wojcicki, Anna V, Ray, Jessica L, Sullivan, Bradley P, Froehlich, John E, Johnson, Brendan F, Flick, Matthew J, Luyendyk, James P

“…Graphical abstract…”
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The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary by Baker, Thomas K, Van Vleet, Terry R, Mahalingaiah, Prathap Kumar, Grandhi, Taraka Sai Pavan, Evers, Raymond, Ekert, Jason, Gosset, James R, Chacko, Silvi A, Kopec, Anna K

“…Microphysiological systems (MPS) are comprised of one or multiple cell types of human or animal origins that mimic the biochemical/electrical/mechanical…”
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Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury by Poole, Lauren G., Kopec, Anna K., Groeneveld, Dafna J., Pant, Asmita, Baker, Kevin S., Cline-Fedewa, Holly M., Flick, Matthew J., Luyendyk, James P.

“…Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by thrombin cleavage of fibrinogen leading to fibrin polymerization…”
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