Search Results - "Kooy, Derek van der"

Cell competition during reprogramming gives rise to dominant clones by Shakiba, Nika, Fahmy, Ahmed, Jayakumaran, Gowtham, McGibbon, Sophie, David, Laurent, Trcka, Daniel, Elbaz, Judith, Puri, Mira C, Nagy, Andras, van der Kooy, Derek, Goyal, Sidhartha, Wrana, Jeffrey L, Zandstra, Peter W

“…The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have…”
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The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin by Smukler, Simon R., Arntfield, Margot E., Razavi, Rozita, Bikopoulos, George, Karpowicz, Phillip, Seaberg, Raewyn, Dai, Feihan, Lee, Simon, Ahrens, Rosemary, Fraser, Paul E., Wheeler, Michael B., van der Kooy, Derek

“…The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived…”
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A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation by Ballios, Brian G., Cooke, Michael J., Donaldson, Laura, Coles, Brenda L.K., Morshead, Cindi M., van der Kooy, Derek, Shoichet, Molly S.

“…The utility of stem cells and their progeny in adult transplantation models has been limited by poor survival and integration. We designed an injectable and…”
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Ventral Tegmental Area BDNF Induces an Opiate-Dependent-Like Reward State in Naïve Rats by Vargas-Perez, Hector, Kee, Ryan Ting -A, Walton, Christine H, Hansen, D. Micah, Razavi, Rozita, Clarke, Laura, Bufalino, Mary Rose, Allison, David W, Steffensen, Scott C, van der Kooy, Derek

“…The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to…”
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Suppression of Oct4 by Germ Cell Nuclear Factor Restricts Pluripotency and Promotes Neural Stem Cell Development in the Early Neural Lineage by Akamatsu, Wado, DeVeale, Brian, Okano, Hideyuki, Cooney, Austin J, van der Kooy, Derek

“…The earliest murine neural stem cells are leukemia inhibitory factor (LIF)-dependent, primitive neural stem cells, which can be isolated from embryonic stem…”
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Retinal Stem Cells in the Adult Mammalian Eye by Tropepe, Vincent, Brenda L. K. Coles, Chiasson, Bernard J., Horsford, D. Jonathan, Elia, Andrew J., McInnes, Roderick R., van der Kooy, Derek

“…The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which…”
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Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse by Pacey, Laura K.K., Doss, Lilian, Cifelli, Carlo, der Kooy, Derek van, Heximer, Scott P., Hampson, David R.

“…Fragile X syndrome (FXS), the most common cause of inherited mental retardation, is caused by the loss of the mRNA binding protein, FMRP. Persons with FXS also…”
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Primitive Neural Stem Cells in the Adult Mammalian Brain Give Rise to GFAP-Expressing Neural Stem Cells by Sachewsky, Nadia, Leeder, Rachel, Xu, Wenjun, Rose, Keeley L., Yu, Fenggang, van der Kooy, Derek, Morshead, Cindi M.

“…Adult forebrain definitive neural stem cells (NSCs) comprise a subpopulation of GFAP-expressing subependymal cells that arise from embryonic fibroblast growth…”
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Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice by Akers, Katherine G, Kushner, Steven A, Leslie, Ana T, Clarke, Laura, van der Kooy, Derek, Lerch, Jason P, Frankland, Paul W

“…Children whose mothers consumed alcohol during pregnancy exhibit widespread brain abnormalities and a complex array of behavioral disturbances. Here, we used a…”
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Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective by DeVeale, Brian, van der Kooy, Derek, Babak, Tomas

“…In contrast to existing estimates of approximately 200 murine imprinted genes, recent work based on transcriptome sequencing uncovered parent-of-origin allelic…”
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The asymmetric segregation of damaged proteins is stem cell-type dependent by Bufalino, Mary Rose, DeVeale, Brian, van der Kooy, Derek

“…Asymmetric segregation of damaged proteins (DPs) during mitosis has been linked in yeast and bacteria to the protection of one cell from aging. Recent evidence…”
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Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse by Babak, Tomas, DeVeale, Brian, Tsang, Emily K, Zhou, Yiqi, Li, Xin, Smith, Kevin S, Kukurba, Kim R, Zhang, Rui, Li, Jin Billy, van der Kooy, Derek, Montgomery, Stephen B, Fraser, Hunter B

“…Hunter Fraser and colleagues generate atlases of imprinted gene expression across many mouse and human tissues. They find that imprinted genes are enriched for…”
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Constraint-Induced Movement Therapy (CIMT) and Neural Precursor Cell (NPC) Transplantation Synergistically Promote Anatomical and Functional Recovery in a Hypoxic-Ischemic Mouse Model by Rumajogee, Prakasham, Altamentova, Svetlana, Li, Junyi, Puvanenthirarajah, Nirushan, Wang, Jian, Asgarihafshejani, Azam, Van Der Kooy, Derek, Fehlings, Michael G

“…Cerebral palsy (CP) is a common neurodevelopmental disorder characterized by pronounced motor dysfunction and resulting in physical disability. Neural…”
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Biology and therapeutic potential of adult retinal stem cells by Ballios, Brian G., BScEng, van der Kooy, Derek, PhD

“…Abstract Retinal degeneration encompasses a constellation of common pathologies for which there is no regenerative treatment. Vision loss has a devastating…”
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The functional landscape of mouse gene expression by Zhang, Wen, Morris, Quaid D, Chang, Richard, Shai, Ofer, Bakowski, Malina A, Mitsakakis, Nicholas, Mohammad, Naveed, Robinson, Mark D, Zirngibl, Ralph, Somogyi, Eszter, Laurin, Nancy, Eftekharpour, Eftekhar, Sat, Eric, Grigull, Jörg, Pan, Qun, Peng, Wen-Tao, Krogan, Nevan, Greenblatt, Jack, Fehlings, Michael, van der Kooy, Derek, Aubin, Jane, Bruneau, Benoit G, Rossant, Janet, Blencowe, Benjamin J, Frey, Brendan J, Hughes, Timothy R

“…Large-scale quantitative analysis of transcriptional co-expression has been used to dissect regulatory networks and to predict the functions of new genes…”
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Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors by Seaberg, Raewyn M, van der Kooy, Derek

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Low Oxygen Enhances Primitive and Definitive Neural Stem Cell Colony Formation by Inhibiting Distinct Cell Death Pathways by Clarke, Laura, van der Kooy, Derek

“…Neural stem cells (NSCs) can be derived from single mouse embryonic stem cells (ESCs) in the absence of instructive factors. Clonal primitive NSC (pNSC)…”
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Neurologic Phenotype of Schimke Immuno-Osseous Dysplasia and Neurodevelopmental Expression of SMARCAL1 by Deguchi, Kimiko, Clewing, Johanna M, Elizondo, Leah I, Hirano, Ryuki, Huang, Cheng, Choi, Kunho, Sloan, Emily A, Lücke, Thomas, Marwedel, Katja M, Powell, Ralph D, Santa Cruz, Karen, Willaime-Morawek, Sandrine, Inoue, Ken, Lou, Shu, Northrop, Jennifer L, Kanemura, Yonehiro, van der Kooy, Derek, Okano, Hideyuki, Armstrong, Dawna L, Boerkoel, Cornelius F

“…Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related,…”
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VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation by Grieder, Taryn E, Herman, Melissa A, Contet, Candice, Tan, Laura A, Vargas-Perez, Hector, Cohen, Ami, Chwalek, Michal, Maal-Bared, Geith, Freiling, John, Schlosburg, Joel E, Clarke, Laura, Crawford, Elena, Koebel, Pascale, Repunte-Canonigo, Vez, P Sanna, Pietro, Tapper, Andrew R, Roberto, Marisa, Kieffer, Brigitte L, Sawchenko, Paul E, Koob, George F, van der Kooy, Derek, George, Olivier

“…Corticotropin-releasing factor (CRF) and dopamine (DA) are critical for stress and motivation, respectively. The authors show that CRF is synthesized in DA…”
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Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries by Karpowicz, Phillip, Cohen, Cynthia B, van der Kooy, Derek

“…The transplantation of adult human neural stem cells into prenatal non-humans offers an avenue for studying human neural cell development without direct use of…”
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