Search Results - "Koorneef, Lisa L."

Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice by Kroon, Jan, Koorneef, Lisa L, van den Heuvel, Jose K, Verzijl, Cristy R C, van de Velde, Nienke M, Mol, Isabel M, Sips, Hetty C M, Hunt, Hazel, Rensen, Patrick C N, Meijer, Onno C

“…Abstract Glucocorticoids influence a wide range of metabolic processes in the human body, and excessive glucocorticoid exposure is known to contribute to the…”
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Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone by Koorneef, Lisa L., van der Meulen, Merel, Kooijman, Sander, Sánchez-López, Elena, Scheerstra, Jari F., Voorhoeve, Maaike C., Ramesh, Ajith N. Nadamuni, Rensen, Patrick C. N., Giera, Martin, Kroon, Jan, Meijer, Onno C.

“…Synthetic glucocorticoids are clinically used to treat auto-immune and inflammatory disease. Despite the high efficacy, glucocorticoid treatments causes side…”
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How Metabolic State May Regulate Fear: Presence of Metabolic Receptors in the Fear Circuitry by Koorneef, Lisa L, Bogaards, Marit, Reinders, Marcel J T, Meijer, Onno C, Mahfouz, Ahmed

“…Metabolic status impacts on the emotional brain to induce behavior that maintains energy balance. While hunger suppresses the fear circuitry to promote…”
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A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function by Kroon, Jan, Schilperoort, Maaike, In het Panhuis, Wietse, van den Berg, Rosa, van Doeselaar, Lotte, Verzijl, Cristy R.C., van Trigt, Nikki, Mol, Isabel M., Sips, Hetty H.C.M., van den Heuvel, Jose K., Koorneef, Lisa L., van der Sluis, Ronald J., Fenzl, Anna, Kiefer, Florian W., Vettorazzi, Sabine, Tuckermann, Jan P., Biermasz, Nienke R., Meijer, Onno C., Rensen, Patrick C.N., Kooijman, Sander

“…Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of…”
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Glucocorticoid receptor modulators by Meijer, Onno C., Koorneef, Lisa L., Kroon, Jan

“…The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target…”
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Hippocampal glucocorticoid target genes associated with enhancement of memory consolidation by Buurstede, Jacobus C., Weert, Lisa T.C.M., Colucci, Paola, Gentenaar, Max, Viho, Eva M.G., Koorneef, Lisa L., Schoonderwoerd, Robin A., Lanooij, Suzanne D., Moustakas, Ioannis, Balog, Judit, Mei, Hailiang, Kielbasa, Szymon M., Campolongo, Patrizia, Roozendaal, Benno, Meijer, Onno C.

“…Glucocorticoids enhance memory consolidation of emotionally arousing events via largely unknown molecular mechanisms. This glucocorticoid effect on the…”
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The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity by Koorneef, Lisa L, Kroon, Jan, Viho, Eva M G, Wahl, Lucas F, Heckmans, Kim M L, van Dorst, Marloes M A R, Hoekstra, Menno, Houtman, René, Hunt, Hazel, Meijer, Onno C

“…Glucocorticoids mediate numerous essential processes in the human body via binding to the glucocorticoid receptor (GR). Excessive GR signaling can cause…”
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Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice by Koorneef, Lisa L, van den Heuvel, José K, Kroon, Jan, Boon, Mariëtte R, 't Hoen, Peter A C, Hettne, Kristina M, van de Velde, Nienke M, Kolenbrander, Kelsey B, Streefland, Trea C M, Mol, Isabel M, Sips, Hetty C M, Kielbasa, Szymon M, Mei, Hailiang, Belanoff, Joseph K, Pereira, Alberto M, Oosterveer, Maaike H, Hunt, Hazel, Rensen, Patrick C N, Meijer, Onno C

“…Medication for nonalcoholic fatty liver disease (NAFLD) is an unmet need. Glucocorticoid (GC) stress hormones drive fat metabolism in the liver, but both full…”
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Transcriptional glucocorticoid effects in the brain: Finding the relevant target genes by Meijer, Onno C., Buurstede, Jacobus C., Viho, Eva M. G., Amaya, Jorge Miguel, Koning, Anne‐Sophie C. A. M., Meulen, Merel, Weert, Lisa T. C. M., Paul, Susana N., Kroon, Jan, Koorneef, Lisa L.

“…Glucocorticoids are powerful modulators of brain function. They act via mineralocorticoid and glucocorticoid receptors (MR and GR). These are best understood…”
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Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males by Janssen, Laura G.M., Nahon, Kimberly J., Bracké, Katrien F.M., van den Broek, Dennis, Smit, Renée, Sardjoe Mishre, Aashley S.D., Koorneef, Lisa L., Martinez-Tellez, Borja, Burakiewicz, Jedrzej, Kan, Hermien E., van Velden, Floris H.P., Pereira Arias-Bouda, Lenka M., de Geus-Oei, Lioe-Fee, Berbée, Jimmy F.P., Jazet, Ingrid M., Boon, Mariëtte R., Rensen, Patrick C.N.

“…Brown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R)…”
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The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models by Kroon, Jan, Viho, Eva M.G., Gentenaar, Max, Koorneef, Lisa L., van Kooten, Cees, Rensen, Patrick C.N., Kooijman, Sander, Hunt, Hazel, Meijer, Onno C.

“…Glucocorticoids regulate numerous processes in human physiology, but deregulated or excessive glucocorticoid receptor (GR) signaling contributes to the…”
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Do Corticosteroid Receptor mRNA Levels Predict the Expression of Their Target Genes? by Koorneef, Lisa L, Viho, Eva M G, Wahl, Lucas F, Meijer, Onno C

“…The glucocorticoid stress hormones affect brain function via high-affinity mineralocorticoid receptors (MRs) and lower-affinity glucocorticoid receptors (GRs)…”
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Selective glucocorticoid receptor modulation prevents and reverses non-alcoholic fatty liver disease in male mice by Koorneef, Lisa L, van den Heuvel, José K, Kroon, Jan, Boon, Mariëtte R, ’t Hoen, Peter A C, Hettne, Kristina M, van de Velde, Nienke M, Kolenbrander, Kelsey B, Streefland, Trea C M, Mol, Isabel M, Sips, Hetty C M, Kielbasa, Szymon M, Mei, Hailiang, Belanoff, Joseph K, Pereira, Alberto M, Oosterveer, Maaike H, Hunt, Hazel, Rensen, Patrick C N, Meijer, Onno C

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