Search Results - "Koontz, Dianna L."

Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA by Hong, Feiyu, Aga, Evgenia, Cillo, Anthony R, Yates, Aarika L, Besson, Guillaume, Fyne, Elizabeth, Koontz, Dianna L, Jennings, Cheryl, Zheng, Lu, Mellors, John W

“…Although a number of PCR-based quantitative assays for measuring HIV-1 persistence during suppressive antiretroviral therapy (ART) have been reported, a…”
Get full text

Associations between HIV-1 DNA copy number, proviral transcriptional activity, and plasma viremia in individuals off or on suppressive antiretroviral therapy by Hong, Feiyu, Jacobs, Jana L., Aga, Evgenia, Cillo, Anthony R., Fyne, Elizabeth, Koontz, Dianna L., Zheng, Lu, Mellors, John W.

“…The relationships between HIV-1 DNA copy number, proviral transcriptional activity, and residual plasma viremia in individuals off and on ART are not well…”
Get full text

Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of HIV-1…”
Get full text

In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase by PARIKH, Urvi M, KOONTZ, Dianna L, CHU, Chung K, SCHINAZI, Raymond F, MELLORS, John W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Automated Multireplicate Quantification of Persistent HIV-1 Viremia in Individuals on Antiretroviral Therapy by Jacobs, Jana L, Tosiano, Melissa A, Koontz, Dianna L, Staines, Brittany, Worlock, Andrew, Harrington, Karen, Bakkour, Sonia, Stone, Mars, Shutt, Kathleen, Busch, Michael P, Mellors, John W

“…Clearance of low-level viremia that persists in most HIV-1-positive individuals on antiretroviral therapy (ART) is an important milestone for efforts to cure…”
Get full text

In Vitro Selection and Analysis of Human Immunodeficiency Virus Type 1 Resistant to Derivatives of β-2′,3′-Didehydro-2′,3′-Dideoxy-5-Fluorocytidine by HAMMOND, Jennifer L, PARIKH, Urvi M, KOONTZ, Dianna L, SCHLUETER-WIRTZ, Susan, CHU, Chung K, BAZMI, Hengameh Z, SCHINAZI, Raymond F, MELLORS, John W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Frequent Emergence of N348I in HIV-1 Subtype C Reverse Transcriptase with Failure of Initial Therapy Reduces Susceptibility to Reverse-Transcriptase Inhibitors by Brehm, Jessica H., Koontz, Dianna L., Wallis, Carole L., Shutt, Kathleen A., Sanne, Ian, Wood, Robin, McIntyre, James A., Stevens, Wendy S., Sluis-Cremer, Nicolas, Mellors, John W.

“…Background. It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line…”
Get full text

Alkylglycerol Prodrugs of Phosphonoformate Are Potent In Vitro Inhibitors of Nucleoside-Resistant Human Immunodeficiency Virus Type 1 and Select for Resistance Mutations That Suppress Zidovudine Resistance by HAMMOND, Jennifer L, KOONTZ, Dianna L, BAZMI, Holly Z, BEADLE, James R, HOSTETLER, Saskia E, KINI, Ganesh D, ALDERN, Kathy A, RICHMAN, Douglas D, HOSTETLER, Karl Y, MELLORS, John W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Hybrids of [TSAO-T]−[Foscarnet]:  The First Conjugate of Foscarnet with a Non-nucleoside Reverse Transcriptase Inhibitor through a Labile Covalent Ester Bond by Velázquez, Sonsoles, Lobatón, Esther, De Clercq, Erik, Koontz, Dianna L, Mellors, John W, Balzarini, Jan

“…This paper describes the first example of combination of non-nucleoside reverse transcriptase inhibitors such as TSAO derivatives and foscarnet (PFA) in a…”
Get full text

Zidovudine by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…Background We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of…”
Get full text