Search Results - "Koontz, Dianna"

Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA by Hong, Feiyu, Aga, Evgenia, Cillo, Anthony R, Yates, Aarika L, Besson, Guillaume, Fyne, Elizabeth, Koontz, Dianna L, Jennings, Cheryl, Zheng, Lu, Mellors, John W

“…Although a number of PCR-based quantitative assays for measuring HIV-1 persistence during suppressive antiretroviral therapy (ART) have been reported, a…”
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Automated Multireplicate Quantification of Persistent HIV-1 Viremia in Individuals on Antiretroviral Therapy by Jacobs, Jana L, Tosiano, Melissa A, Koontz, Dianna L, Staines, Brittany, Worlock, Andrew, Harrington, Karen, Bakkour, Sonia, Stone, Mars, Shutt, Kathleen, Busch, Michael P, Mellors, John W

“…Clearance of low-level viremia that persists in most HIV-1-positive individuals on antiretroviral therapy (ART) is an important milestone for efforts to cure…”
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Associations between HIV-1 DNA copy number, proviral transcriptional activity, and plasma viremia in individuals off or on suppressive antiretroviral therapy by Hong, Feiyu, Jacobs, Jana L., Aga, Evgenia, Cillo, Anthony R., Fyne, Elizabeth, Koontz, Dianna L., Zheng, Lu, Mellors, John W.

“…The relationships between HIV-1 DNA copy number, proviral transcriptional activity, and residual plasma viremia in individuals off and on ART are not well…”
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Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells by Bui, John K, Halvas, Elias K, Fyne, Elizabeth, Sobolewski, Michele D, Koontz, Dianna, Shao, Wei, Luke, Brian, Hong, Feiyu F, Kearney, Mary F, Mellors, John W

“…The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4+ T-cells containing…”
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The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog Mutations by PARIKH, Urvi M, BACHELER, Lee, KOONTZ, Dianna, MELLORS, John W

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Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Increase Resistance to 3′-Azido-3′-Dideoxythymidine by BREHM, Jessica H, KOONTZ, Dianna, METEER, Jeffrey D, PATHAK, Vinay, SLUIS-CREMER, Nicolas, MELLORS, John W

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Frequent Emergence of N348I in HIV-1 Subtype C Reverse Transcriptase with Failure of Initial Therapy Reduces Susceptibility to Reverse-Transcriptase Inhibitors by Brehm, Jessica H., Koontz, Dianna L., Wallis, Carole L., Shutt, Kathleen A., Sanne, Ian, Wood, Robin, McIntyre, James A., Stevens, Wendy S., Sluis-Cremer, Nicolas, Mellors, John W.

“…Background. It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line…”
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Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of HIV-1…”
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In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase by PARIKH, Urvi M, KOONTZ, Dianna L, CHU, Chung K, SCHINAZI, Raymond F, MELLORS, John W

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Anti-Human Immunodeficiency Virus Activity, Cross-Resistance, Cytotoxicity, and Intracellular Pharmacology of the 3′-Azido-2′,3′-Dideoxypurine Nucleosides by SLUIS-CREMER, Nicolas, KOONTZ, Dianna, SCHINAZI, Raymond F, MELLORS, John W, BASSIT, Leda, HERNANDEZ-SANTIAGO, Brenda I, DETORIO, Mervi, RAPP, Kim L, AMBLARD, Franck, BONDADA, Lavanya, GRIER, Jason, COATS, Steven J

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The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase by METEER, Jeffrey D, KOONTZ, Dianna, ASIF, Ghazia, ZHANG, Hong-Wang, DETORIO, Mervi, SOLOMON, Sarah, COATS, Steven J, SLUIS-CREMER, Nicolas, SCHINAZI, Raymond F, MELLORS, John W

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In Vitro Selection and Analysis of Human Immunodeficiency Virus Type 1 Resistant to Derivatives of β-2′,3′-Didehydro-2′,3′-Dideoxy-5-Fluorocytidine by HAMMOND, Jennifer L, PARIKH, Urvi M, KOONTZ, Dianna L, SCHLUETER-WIRTZ, Susan, CHU, Chung K, BAZMI, Hengameh Z, SCHINAZI, Raymond F, MELLORS, John W

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Hybrids of [TSAO-T]−[Foscarnet]:  The First Conjugate of Foscarnet with a Non-nucleoside Reverse Transcriptase Inhibitor through a Labile Covalent Ester Bond by Velázquez, Sonsoles, Lobatón, Esther, De Clercq, Erik, Koontz, Dianna L, Mellors, John W, Balzarini, Jan

“…This paper describes the first example of combination of non-nucleoside reverse transcriptase inhibitors such as TSAO derivatives and foscarnet (PFA) in a…”
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Alkylglycerol Prodrugs of Phosphonoformate Are Potent In Vitro Inhibitors of Nucleoside-Resistant Human Immunodeficiency Virus Type 1 and Select for Resistance Mutations That Suppress Zidovudine Resistance by HAMMOND, Jennifer L, KOONTZ, Dianna L, BAZMI, Holly Z, BEADLE, James R, HOSTETLER, Saskia E, KINI, Ganesh D, ALDERN, Kathy A, RICHMAN, Douglas D, HOSTETLER, Karl Y, MELLORS, John W

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Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus–1 by Riddler, Sharon A, Para, Michael, Benson, Constance A, Mills, Anthony, Ramgopal, Moti, DeJesus, Edwin, Brinson, Cynthia, Cyktor, Joshua, Jacobs, Jana, Koontz, Dianna, Mellors, John W, Laird, Gregory M, Wrin, Terri, Patel, Heena, Guo, Susan, Wallin, Jeffrey, Boice, Jillian, Zhang, Liao, Humeniuk, Rita, Begley, Rebecca, German, Polina, Graham, Hiba, Geleziunas, Romas, Brainard, Diana M, SenGupta, Devi

“…Abstract Background Treatment with vesatolimod, an investigational, oral, toll-like receptor 7 (TLR7) agonist, leads to sustained viral remission in some…”
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Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance by Spudich, Serena, Robertson, Kevin R, Bosch, Ronald J, Gandhi, Rajesh T, Cyktor, Joshua C, Mar, Hanna, Macatangay, Bernard J, Lalama, Christina M, Rinaldo, Charles, Collier, Ann C, Godfrey, Catherine, Eron, Joseph J, McMahon, Deborah, Jacobs, Jana L, Koontz, Dianna, Hogg, Evelyn, Vecchio, Alyssa, Mellors, John W

“…BACKGROUNDPersistence of HIV in sanctuary sites despite antiretroviral therapy (ART) presents a barrier to HIV remission and may affect neurocognitive…”
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Improved single-copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy by Cillo, Anthony R, Vagratian, David, Bedison, Margaret A, Anderson, Elizabeth M, Kearney, Mary F, Fyne, Elizabeth, Koontz, Dianna, Coffin, John M, Piatak, Jr, Michael, Mellors, John W

“…A quantitative real-time PCR (qRT-PCR) assay with single-copy sensitivity targeting HIV-1 gag RNA (the gag single-copy assay [gSCA]) has been used widely to…”
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Ex vivo activation of CD4.sup.+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells by Bui, John K, Halvas, Elias K, Fyne, Elizabeth, Sobolewski, Michele D, Koontz, Dianna, Shao, Wei, Luke, Brian, Hong, Feiyu F, Kearney, Mary F, Mellors, John W

“…The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4.sup.+ T-cells…”
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Zidovudine by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…Background We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of…”
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The 3′-Azido Group Is Not the Primary Determinant of 3′-Azido-3′-deoxythymidine (AZT) Responsible for the Excision Phenotype of AZT-resistant HIV-1 by Sluis-Cremer, Nicolas, Arion, Dominique, Parikh, Urvi, Koontz, Dianna, Schinazi, Raymond F., Mellors, John W., Parniak, Michael A.

“…The mechanism of human immunodeficiency virus (HIV) 1 resistance to 3′-azido-3′-deoxythymidine (AZT) involves reverse transcriptase (RT)-catalyzed…”
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