Search Results - "Koomans, Hein A."

Sympathetic hyperactivity in chronic kidney disease: Pathogenesis, clinical relevance, and treatment by Neumann, Jutta, Ligtenberg, Gerry, Klein, Inge I., Koomans, Hein A., Blankestijn, Peter J.

“…Sympathetic hyperactivity in chronic kidney disease: Pathogenesis, clinical relevance, and treatment. Cardiovascular morbidity and mortality importantly…”
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Causes and Consequences of Increased Sympathetic Activity in Renal Disease by Joles, Jaap A, Koomans, Hein A

“…ABSTRACT—Much evidence indicates increased sympathetic nervous activity (SNA) in renal disease. Renal ischemia is probably a primary event leading to increased…”
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Sympathetic Hyperactivity in Hypertensive Chronic Kidney Disease Patients Is Reduced During Standard Treatment by Neumann, Jutta, Ligtenberg, Gerry, Klein, Inge H.T, Boer, Peter, Oey, P Liam, Koomans, Hein A, Blankestijn, Peter J

“…Standard treatment in chronic kidney disease (CKD) patients includes an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. CKD is…”
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End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells by Westerweel, Peter E, Hoefer, Imo E, Blankestijn, Peter J, de Bree, Petra, Groeneveld, Dafna, van Oostrom, Olivia, Braam, Branko, Koomans, Hein A, Verhaar, Marianne C

“…Patients with end-stage renal disease (ESRD) on hemodialysis have an increased risk of cardiovascular disease (CVD). Circulating endothelial progenitor cells…”
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Sympathetic nerve activity is inappropriately increased in chronic renal disease by KLEIN, Inge H. H. T, LIGTENBERG, Gerry, NEUMANN, Jutta, OEY, P. Liam, KOOMANS, Hein A, BLANKESTIJN, Peter J

“…The hypothesis that in hypertensive patients with renal parenchymal disease sympathetic activity is "inappropriately" elevated and that this overactivity is a…”
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Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade by VERHAAR, M. C, STRACHAN, F. E, NEWBY, D. E, CRUDEN, N. L, KOOMANS, H. A, RABELINK, T. J, WEBB, D. J

“…The role of endothelin (ET)-1 in maintenance of basal vascular tone has been demonstrated by local and systemic vasodilatation to endothelin receptor…”
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Early mechanisms of renal injury in hypercholesterolemic or hypertriglyceridemic rats by JOLES, J. A, KUNTER, U, JANSSEN, U, KRIZ, W, RABELINK, T. J, KOOMANS, H. A, FLOEGE, J

“…Hyperlipidemia in conjunction with uninephrectomy leads to renal injury in rats. It is unknown whether this is due to mesangial cell or podocyte injury and…”
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Effects of Endothelin-1 and Endothelin-1 Receptor Blockade on Cardiac Output, Aortic Pressure, and Pulse Wave Velocity in Humans by Vuurmans, Tycho J.L, Boer, Peter, Koomans, Hein A

“…ABSTRACT—Endothelin-1 (ET-1) is a potent vasoconstrictor. Its effect on arterial wave reflections and central pressure augmentation is unknown. We studied…”
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Contribution of volume overload and angiotensin II to the increased pulse wave velocity of hemodialysis patients by TYCHO VUURMANS, J. L, BOER, Walther H, BOS, Willem-Jan W, BLANKESTIJN, Peter J, KOOMANS, Hein A

“…Aortic compliance is decreased in patients with end-stage renal disease. This malfunction contributes to high aortic systolic pressures and thus to the…”
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Pathophysiology of acute renal failure in idiopatic nephrotic syndrome by KOOMANS, Hein A

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Broadly Altered Gene Expression in Blood Leukocytes in Essential Hypertension Is Absent During Treatment by Chon, Helena, Gaillard, Carlo A.J.M, van der Meijden, Brenda B, Dijstelbloem, Hilde M, Kraaijenhagen, Rob J, van Leenen, Dik, Holstege, Frank C.P, Joles, Jaap A, Bluyssen, Hans A.R, Koomans, Hein A, Braam, Branko

“…ABSTRACT—We assessed whether large-scale expression profiling of leukocytes of patients with essential hypertension reflects characteristics of systemic…”
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Hypercholesterolemia in rats induces podocyte stress and decreases renal cortical nitric oxide synthesis via an angiotensin II type 1 receptor-sensitive mechanism by ATTIA, Diana M, FERON, Olivier, GOLDSCHMEDING, Roel, RADERMAKERS, Louk H, VAZIRI, Nosratola D, BOER, Peter, BALLIGAND, Jean-Luc, KOOMANS, Hein A, JOLES, Jaap A

“…Podocyte stress precedes proteinuria in hypercholesterolemic rats. Molsidomine, a nitric oxide (NO) donor, prevented podocyte stress and proteinuria in…”
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Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension by Racasan, Simona, Hahnel, Bruni, Van Dergiezen, Dionne M., Blezer, Erwin L., Goldschmeding, Roel, Braam, Branko, Kriz, Wilhem, Koomans, Hein A., Joles, Jaap A.

“…Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension. Exposure of normotensive rats to…”
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Sympathetic hyperactivity in chronic renal failure: A wake-up call by KOOMANS, Hein A, BLANKESTIJN, Peter J, JOLES, Jaap A

“…Sympathetic hyperactivity plays an important and distinct role in hypertension associated with chronic renal failure (CRF). Renal ischemia, elevated…”
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Maternal Supplementation With Citrulline Increases Renal Nitric Oxide in Young Spontaneously Hypertensive Rats and Has Long-Term Antihypertensive Effects by Koeners, Maarten P, van Faassen, Ernst E, Wesseling, Sebastiaan, de Sain-van der Velden, Monique, Koomans, Hein A, Braam, Branko, Joles, Jaap A

“…NO deficiency is associated with development of hypertension. Defects in the renal citrulline-arginine pathway or arginine reabsorption potentially reduce…”
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Cyclosporin A Increases Nitric Oxide Activity In Vivo by Stroes, Erick S.G, Luscher, Thomas F, de Groot, Flip G, Koomans, Hein A, Rabelink, Ton J

“…The use of cyclosporine is complicated by its vasoconstrictive actions. In vitro cyclosporine has been associated with both decreased endothelium-dependent…”
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Hypoxanthine plus xanthine oxidase causes profound natriuresis without affecting renal blood flow autoregulation by Racasan, Simona, Turkstra, Erika, Joles, Jaap A., Koomans, Hein A., Braam, Branko

“…Hypoxanthine plus xanthine oxidase causes profound natriuresis without affecting renal blood flow autoregulation. Enhanced superoxide (O2−•) production by…”
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Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus by Westerweel, Peter E, Luijten, Remco K M A C, Hoefer, Imo E, Koomans, Hein A, Derksen, Ronald H W M, Verhaar, Marianne C

“…Background: Systemic lupus erythematosus (SLE) is associated with a high prevalence of cardiovascular disease. Circulating endothelial progenitor cells (EPCs)…”
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Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension by KLEIN, Inge H. H. T, LIGTENBERG, Gerry, OEY, P. Liam, KOOMANS, Hein A, BLANKESTIJN, Peter J

“…Hypertension is common in patients with polycystic kidney disease (PKD). This study addresses the hypothesis that sympathetic activity is enhanced in…”
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Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon by Racasan, Simona, Braam, Branko, Koomans, Hein A, Joles, Jaap A

“…The "programming hypothesis" proposes that an adverse perinatal milieu leads to adaptation that translates into cardiovascular disease in adulthood. The…”
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