Search Results - "Kooij, Viola"

Characterization of the cardiac myosin binding protein-C phosphoproteome in healthy and failing human hearts by Kooij, Viola, Holewinski, Ronald J, Murphy, Anne M, Van Eyk, Jennifer E

“…Abstract Introduction Cardiac myosin binding protein-C (cMyBP-C) becomes dephosphorylated in the failing heart and reduced phosphorylation-dependent regulation…”
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Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy by Kooij, Viola, Viswanathan, Meera C, Lee, Dong I, Rainer, Peter P, Schmidt, William, Kronert, William A, Harding, Sian E, Kass, David A, Bernstein, Sanford I, Van Eyk, Jennifer E, Cammarato, Anthony

“…Heart failure is often preceded by cardiac hypertrophy, which is characterized by increased cell size, altered protein abundance, and actin cytoskeletal…”
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PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis by Kooij, Viola, Zhang, Pingbo, Piersma, Sander R, Sequeira, Vasco, Boontje, Nicky M, Wijnker, Paul J M, Jiménez, Connie R, Jaquet, Kornelia E, dos Remedios, Cris, Murphy, Anne M, Van Eyk, Jennifer E, van der Velden, Jolanda, Stienen, Ger Jm

“…Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a…”
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More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease by Hamdani, Nazha, Borbély, Attila, Veenstra, Sophie P. G. R., Kooij, Viola, Vrydag, Wim, Zaremba, Ruud, dos Remedios, Cris, Niessen, Hans W. M., Michel, Martin C., Paulus, Walter J., Stienen, Ger J. M., van der Velden, Jolanda

“…Activation of the β-adrenergic receptor (βAR) pathway is the main mechanism of the heart to increase cardiac output via protein kinase A (PKA)-mediated…”
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Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC by de Oliveira, Inês Filipa Fernandes, de Sousa Borges, Anabela, Kooij, Viola, Bartosiak-Jentys, Jeremy, Luirink, Joen, Scheffers, Dirk-Jan

“…Cell division in Bacillus subtilis occurs precisely at midcell. Positional control of cell division is exerted by two mechanisms: nucleoid occlusion, through…”
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Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3[Beta] by Kirk, Jonathan A, Holewinski, Ronald J, Kooij, Viola, Agnetti, Giulio, Tunin, Richard S, Witayavanitkul, Namthip, de Tombe, Pieter P, Gao, Wei Dong, Van Eyk, Jennifer, Kass, David A

“…Cardiac resynchronization therapy (CRT), the application of biventricular stimulation to correct discoordinate contraction, is the only heart failure treatment…”
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Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β by Kirk, Jonathan A, Holewinski, Ronald J, Kooij, Viola, Agnetti, Giulio, Tunin, Richard S, Witayavanitkul, Namthip, de Tombe, Pieter P, Gao, Wei Dong, Van Eyk, Jennifer, Kass, David A

“…Cardiac resynchronization therapy (CRT), the application of biventricular stimulation to correct discoordinate contraction, is the only heart failure treatment…”
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Sarcomeric dysfunction in heart failure by Hamdani, Nazha, Kooij, Viola, van Dijk, Sabine, Merkus, Daphne, Paulus, Walter J., Remedios, Cris dos, Duncker, Dirk J., Stienen, Ger J.M., van der Velden, Jolanda

“…Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in…”
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Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium by Kooij, Viola, Boontje, Nicky, Zaremba, Ruud, Jaquet, Kornelia, dos Remedios, Cris, Stienen, Ger J. M., van der Velden, Jolanda

“…Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be…”
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Sizing up models of heart failure: Proteomics from flies to humans by Kooij, Viola, Venkatraman, Vidya, Tra, John, Kirk, Jonathan A., Rowell, Janelle, Blice-Baum, Anna, Cammarato, Anthony, Van Eyk, Jennifer E.

“…Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various…”
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Effect of troponin I Ser23/24 phosphorylation on Ca2+ -sensitivity in human myocardium depends on the phosphorylation background by Kooij, Viola, Saes, Martina, Jaquet, Kornelia, Zaremba, Ruud, Foster, D. Brian, Murphy, Anne M, dos Remedios, Cris, van der Velden, Jolanda, Stienen, Ger J.M

“…Abstract Protein kinase A (PKA)-mediated phosphorylation of Ser23/24 of cardiac troponin I (cTnI) causes a reduction in Ca2+ -sensitivity of force development…”
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Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity by Ramirez-Correa, Genaro A, Frazier, Aisha H, Zhu, Guangshuo, Zhang, Pingbo, Rappold, Thomas, Kooij, Viola, Bedja, Djahida, Snyder, Greg A, Lugo-Fagundo, Nahyr S, Hariharan, Raena, Li, Yuejin, Shen, Xiaoxu, Gao, Wei Dong, Cingolani, Oscar H, Takimoto, Eiki, Foster, D Brian, Murphy, Anne M

“…Troponin I (TnI) variant Pro82Ser (cTnIP82S) was initially considered a disease-causing mutation; however, later studies suggested the contrary. We tested the…”
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Novel Phosphorylation Sites and Reduced Phosphorylation Levels in Human Cardiac MyBP-C from Failing Hearts by Kooij, Viola, Ji, Weihua, Wang, Sheng-bing, dos Remedios, Cris, Murphy, Anne M., Van Eyk, Jennifer E.

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Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts [Beta]-adrenergic response, and impairs myofilament cooperativity by Ramirez-Correa, Genaro A, Frazier, Aisha H, Zhu, Guangshuo, Zhang, Pingbo, Rappold, Thomas, Kooij, Viola, Bedja, Djahida, Snyder, Greg A, Lugo-Fagundo, Nahyr S, Hariharan, Raena, Li, Yuejin, Shen, Xiaoxu, Gao, Wei Dong, Cingolani, Oscar H, Takimoto, Eiki, Foster, D Brian, Murphy, Anne M

“…Troponin I (TnI) variant Pro82Ser (cTnIP82S) was initially considered a disease-causing mutation; however, later studies suggested the contrary. We tested the…”
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Effect of Troponin I Ser23/24 Bis-Phosphorylation on Ca2+-Sensitivity is Dependent on PKA Phosphorylation of Other Contractile Proteins by Kooij, Viola, van der Velden, Jolanda, Stienen, Ger J.M.

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PKC[alpha]-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis by Kooij, Viola, Zhang, Pingbo, Piersma, Sander R, Sequeira, Vasco, Boontje, Nicky M, Wijnker, Paul J. M, Jiménez, Connie R, Jaquet, Kornelia E, dos Remedios, Cris, Murphy, Anne M, Van Eyk, Jennifer E, van der Velden, Jolanda, Stienen, Ger JM

“…Aims Protein kinase C[alpha] (PKC[alpha]) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKC[alpha] is implicated in heart failure…”
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Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches by Kooij, Viola, Venkatraman, Vidya, Kirk, Jonathan A., Ubaida-Mohien, Ceereena, Graham, David R., Faber, Matthijs J., Van Eyk, Jennifer E.

“…Purpose The identification of protein isoforms in complex biological samples is challenging. We, therefore, used an MS approach to unambiguously identify…”
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Myofilament dysfunction in cardiac disease from mice to men by Hamdani, Nazha, de Waard, Monique, Messer, Andrew E, Boontje, Nicky M, Kooij, Viola, van Dijk, Sabine, Versteilen, Amanda, Lamberts, Regis, Merkus, Daphne, dos Remedios, Cris, Duncker, Dirk J, Borbely, Attila, Papp, Zoltan, Paulus, Walter, Stienen, Ger J. M, Marston, Steven B, van der Velden, Jolanda

“…In healthy human myocardium a tight balance exists between receptor-mediated kinases and phosphatases coordinating phosphorylation of regulatory proteins…”
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Protein Kinase Cα Mediated Phosphorylation of Cardiac Troponin Reduces Maximal Force and Exerts Dual Effects on Ca2+-Sensitivity in Human Cardiomyocytes by Kooij, Viola, Piersma, Sander R., Zhang, Pingbo, Boontje, Nicky M., Jiménez, Connie R., Jaquet, Kornelia, dos Remedios, Cris, Murphy, Anne, van Eyk, Jennifer, van der Velden, Jolanda, Stienen, Ger J.

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Protein Kinase Cα Mediated Phosphorylation of Cardiac Troponin Reduces Maximal Force and Exerts Dual Effects on Ca 2+-Sensitivity in Human Cardiomyocytes by Kooij, Viola, Piersma, Sander R., Zhang, Pingbo, Boontje, Nicky M., Jiménez, Connie R., Jaquet, Kornelia, dos Remedios, Cris, Murphy, Anne, van Eyk, Jennifer, van der Velden, Jolanda, Stienen, Ger J.

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