Assessment of the association between body composition and risk of non-alcoholic fatty liver

Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrit...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 4; p. e0249223
Main Authors:	Ariya, Mohammad, Koohpayeh, Farbod, Ghaemi, Alireza, Osati, Saeed, Davoodi, Sayed Hossain, Razzaz, Jalaledin Mirzay, Javedan, Gholamali, Ehrampoush, Elham, Homayounfar, Reza
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-04-2021 Public Library of Science (PLoS)
Subjects:	Abdomen Abuse Addictions Adipose tissues Age Biology and Life Sciences Blood pressure Body composition Body weight loss Cancer Cardiovascular disease Consent Diabetes Drug abuse Fatty liver Fibrosis Food Food science Food technology Health aspects Health risks Liver Liver diseases Medical research Medicine and Health Sciences Metabolism Nutrition Obesity Physiological aspects Public health Questionnaires Research facilities Risk analysis Risk factors Surgery Technology Transplants & implants Visualization Weight control Weight loss Womens health Iran Japan
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Summary:	Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrition clinic from 2016 to 2017 in Tehran, Iran. The liver steatosis was calculated using the CAP score through the FiroScan™ and body composition was measured using the dual-energy X-ray absorptiometry scan method. A total of 2160 patients participated in this study, 745 (34.5%) subjects had NAFLD. We found that fat-free tissue was inversely and fat tissue was directly correlated with the risk of NAFLD in almost all factors and the risk of developing NAFLD increases if the total fat exceeds 32.23% and 26.73% in women and men and abdominal fat exceeds 21.42% and 13.76% in women and men, respectively. Finally, we realized that the total fat percent had the highest AUC (0.932 for men and 0.917 for women) to predict the risk of NAFLD. Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors hereby affirm that the manuscript is original, that all statements asserted as facts are based on authors’ careful investigation and accuracy, that the manuscript has not been published in total or in part previously and has not been submitted or considered for publication in total or in part elsewhere. Each author acknowledges he/she has participated in the work substantively and is prepared to take public responsibility for the work and authors have no competing interest in the results of the article.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0249223