Search Results - "Koob, G.F."

S.4.01 Molecular approaches to future treatments by Koob, G.F

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P.3.a.009 Samidorphan attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in rats by Cunningham, J.I, Dean, R.L, Todtenkopf, M.S, Azar, M.R, Koob, G.F, Deaver, D.R, Eyerman, D.J

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S.03.05 Hypocretin/orexin in addiction: a mediator of stress-induced reinstatement of cocaine-seeking behaviour by Boutrel, B, de Lecea, L, Koob, G.F

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Destruction of the locus coeruleus decreases physical signs of opiate withdrawal by Maldonado, R, Koob, G F

“…The purpose of the present study was to investigate the role of the locus coeruleus in the development of opiate dependence. Two groups of rats each were…”
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Role of the amygdala oxytocin system in a rat model of alcohol dependence by Tunstall, B.J., Gonzales, L., Vendruscolo, J.C.M., Zallar, L.J., McConnell, S.A., Ho, C.P., Koob, G.F., Vendruscolo, L.F.

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A relationship between the aldosterone–mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans by Aoun, E G, Jimenez, V A, Vendruscolo, L F, Walter, N A R, Barbier, E, Ferrulli, A, Haass-Koffler, C L, Darakjian, P, Lee, M R, Addolorato, G, Heilig, M, Hitzemann, R, Koob, G F, Grant, K A, Leggio, L

“…Aldosterone regulates electrolyte and fluid homeostasis through binding to the mineralocorticoid receptors (MRs). Previous work provides evidence for a role of…”
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Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model by Zallar, L. J., Tunstall, B. J., Richie, C. T., Zhang, Y. J., You, Z. B., Gardner, E. L., Heilig, M., Pickel, J., Koob, G. F., Vendruscolo, L. F., Harvey, B. K., Leggio, L.

“…Background/objectives Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by…”
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Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats by Korte, S M, Korte-Bouws, G A, Bohus, B, Koob, G F

“…Defensive burying behavior is a coping strategy in rodents in response to an aversive stimulus where fear will facilitate burying and treatment with…”
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Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics by Swerdlow, N R, Braff, D L, Geyer, M A, Koob, G F

“…Schizophrenic patients show loss of the normal inhibition of the acoustic startle response (ASR) when the startle stimulus is preceded by a weak prepulse…”
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Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry by Swerdlow, N R, Koob, G F

“…A GABAergic nucleus accumbens-ventral pallidum projection is believed to serve as the critical first-order accumbens efferent pathway underlying the behavioral…”
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Centrally injected arginine vasopressin (AVP) facilitates social memory in rats by Le Moal, M, Dantzer, R, Michaud, B, Koob, G F

“…'Memory' for a juvenile conspecific in male rats can be measured by variation in duration of investigation times when the same juvenile is presented at…”
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Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens by Roberts, D C, Koob, G F, Klonoff, P, Fibiger, H C

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Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats by Tazi, A, Dantzer, R, Le Moal, M, Rivier, J, Vale, W, Koob, G F

“…Corticotropin-releasing factor (CRF) has been shown to have potent central nervous system-activating effects when administered intracerebroventricularly…”
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The origin and distribution of dopamine-containing afferents to the rat frontal cortex by Emson, P C, Koob, G F

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208. Corticotropin releasing factor, stress and allostasis by Koob, G.F.

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Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence by Contet, Candice, Gardon, Olivier, Filliol, Dominique, Becker, Jérôme A. J., Koob, George F., Kieffer, Brigitte L.

“…ABSTRACT Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes…”
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Genetic Differences in Response to Novelty and Spatial Memory Using a Two-Trial Recognition Task in Mice by Dellu, F., Contarino, A., Simon, H., Koob, G.F., Gold, L.H.

“…A two-trial memory task, based on a free-choice exploration paradigm in a Y-maze, was previously developed to study recognition processes in Sprague-Dawley…”
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Appetite-suppressing effects on urocortin, a CRF-related neuropeptide by Spina, Mariarosa, Merlo-Pich, Emilio, Raymond K. W. Chan, Basso, Ana Maria, Rivier, Jean, Vale, Wylie, Koob, George F.

“…The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in…”
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Animal models of addictive disorders by Koob, G.F.

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Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety by Swerdlow, N R, van der Kooy, D, Koob, G F, Wenger, J R

“…The net reinforcing/aversive properties of cholecystokinin (CCK) were measured using a conditioned place-preference paradigm. Both sated and food-deprived rats…”
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