Search Results - "Kontula, K."

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum by Kumar, Anmol, Mutter, Stefan, Parente, Erika B, Harjutsalo, Valma, Lithovius, Raija, Mathavan, Sinnakaruppan, Lehto, Markku, Hiltunen, Timo P, Kontula, Kimmo K, Groop, Per-Henrik

“…Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). Previously, we have reported an association between mutations in a…”
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Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension by Hiltunen, Timo P, Rimpelä, Jenni M, Mohney, Robert P, Stirdivant, Steven M, Kontula, Kimmo K

“…In order to search for metabolic biomarkers of antihypertensive drug responsiveness, we measured >600 biochemicals in plasma samples of subjects participating…”
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Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design by Nuotio, Marja-Liisa, Sánez Tähtisalo, Heini, Lahtinen, Alexandra, Donner, Kati, Fyhrquist, Frej, Perola, Markus, Kontula, Kimmo K, Hiltunen, Timo P

“…Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA…”
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Bloodstream infections following different types of surgery in a Finnish tertiary care hospital, 2009–2014 by Skogberg, K., Kontula, K.S.K., Järvinen, A., Lyytikäinen, O.

“…The risk and outcome of bloodstream infections (BSIs) were evaluated following surgery. BSIs were identified in Helsinki University Hospital during 2009–2014…”
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Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study by Sánez Tähtisalo, Heini, Hiltunen, Timo P, Kenttä, Tuomas, Junttila, Juhani, Oikarinen, Lasse, Virolainen, Juha, Kontula, Kimmo K, Porthan, Kimmo

“…T-wave area dispersion (TW-Ad) is a novel electrocardiographic (ECG) repolarization marker associated with sudden cardiac death. However, limited data is…”
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Regulation of AT1R expression through HuR by insulin by Paukku, Kirsi, Backlund, Michael, De Boer, Rudolf A, Kalkkinen, Nisse, Kontula, Kimmo K, Lehtonen, Jukka Y A

“…Angiotensin II type 1 receptor (AT1R) has a pathophysiological role in hypertension, atherosclerosis and heart failure. Type 2 diabetes is hyperinsulinemic…”
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Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase by Backlund, Michael, Paukku, Kirsi, Daviet, Laurent, De Boer, Rudolf A, Valo, Erkka, Hautaniemi, Sampsa, Kalkkinen, Nisse, Ehsan, Afshin, Kontula, Kimmo K, Lehtonen, Jukka Y.A

“…Regulation of angiotensin II type 1 receptor (AT1R) has a pathophysiological role in hypertension, atherosclerosis and heart failure. We started from an…”
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Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies) by Singh, Sonal, Warren, Helen R, Hiltunen, Timo P, McDonough, Caitrin W, El Rouby, Nihal, Salvi, Erika, Wang, Zhiying, Garofalidou, Tatiana, Fyhrquist, Frej, Kontula, Kimmo K, Glorioso, Valeria, Zaninello, Roberta, Glorioso, Nicola, Pepine, Carl J, Munroe, Patricia B, Turner, Stephan T, Chapman, Arlene B, Boerwinkle, Eric, Johnson, Julie A, Gong, Yan, Cooper-DeHoff, Rhonda M

“…BackgroundThere exists a wide interindividual variability in blood pressure (BP) response to β1‐blockers. To identify the genetic determinants of this…”
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Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients by Rimpelä, Jenni M, Pörsti, Ilkka H, Jula, Antti, Lehtimäki, Terho, Niiranen, Teemu J, Oikarinen, Lasse, Porthan, Kimmo, Tikkakoski, Antti, Virolainen, Juha, Kontula, Kimmo K, Hiltunen, Timo P

“…Reduced nocturnal fall (non-dipping) of blood pressure (BP) is a predictor of cardiovascular target organ damage. No genome-wide association studies (GWAS) on…”
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Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol by Fontana, Vanessa, Turner, Richard Myles, Francis, Ben, Yin, Peng, Pütz, Benno, Hiltunen, Timo P, Ruotsalainen, Sanni, Kontula, Kimmo K, Müller-Myhsok, Bertam, Pirmohamed, Munir

“…Bisoprolol is a widely used beta-blocker in patients with cardiovascular diseases. As with other beta-blockers, there is variability in response to bisoprolol,…”
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Genome-wide association study of white-coat effect in hypertensive patients by Rimpelä, Jenni M, Niiranen, Teemu, Jula, Antti, Pörsti, Ilkka H, Tikkakoski, Antti, Havulinna, Aki, Lehtimäki, Terho, Salomaa, Veikko, Kontula, Kimmo K, Hiltunen, Timo P

“…White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to…”
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CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn’s disease by Heliö, T, Halme, L, Lappalainen, M, Fodstad, H, Paavola-Sakki, P, Turunen, U, Färkkilä, M, Krusius, T, Kontula, K

“…Background: Variants of the caspase activating recruitment domain 15/nucleotide oligomerisation domain 2 (CARD15/NOD2) gene have been associated with…”
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Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study by Fyhrquist, F, Silventoinen, K, Saijonmaa, O, Kontula, K, Devereux, R B, de Faire, U, Os, I, Dahlöf, B

“…Short telomeres are associated with aging and age-related diseases. Our aim was to determine whether short leukocyte telomere length is associated with risk…”
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p100 increases AT1R expression through interaction with AT1R 3'-UTR by Paukku, Kirsi, Kalkkinen, Nisse, Silvennoinen, Olli, Kontula, Kimmo K, Lehtonen, Jukka Y.A

“…p100 protein (SND1, Tudor-SN) is a multifunctional protein that functions as a co-activator for several transcription factors, has a role in mRNA processing…”
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TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives by Chittani, Martina, Zaninello, Roberta, Lanzani, Chiara, Frau, Francesca, Ortu, Maria F, Salvi, Erika, Fresu, Giovanni, Citterio, Lorena, Braga, Daniele, Piras, Daniela A, Carpini, Simona Delli, Velayutham, Dinesh, Simonini, Marco, Argiolas, Giuseppe, Pozzoli, Simona, Troffa, Chiara, Glorioso, Valeria, Kontula, Kimmo K, Hiltunen, Timo P, Donner, Kati M, Turner, Stephen T, Boerwinkle, Eric, Chapman, Arlene B, Padmanabhan, Sandosh, Dominiczak, Anna F, Melander, Olle, Johnson, Julie A, Cooper-Dehoff, Rhonda M, Gong, Yan, Rivera, Natalia V, Condorelli, Gianluigi, Trimarco, Bruno, Manunta, Paolo, Cusi, Daniele, Glorioso, Nicola, Barlassina, Cristina

“…BACKGROUND:Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of ‘the right drug in the individual…”
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Common Genetic Variants, QT Interval, and Sudden Cardiac Death in a Finnish Population-Based Study by Noseworthy, Peter A, Havulinna, Aki S, Porthan, Kimmo, Lahtinen, Annukka M, Jula, Antti, Karhunen, Pekka J, Perola, Markus, Oikarinen, Lasse, Kontula, Kimmo K, Salomaa, Veikko, Newton-Cheh, Christopher

“…BACKGROUND—Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded…”
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Work Stress and the Long QT Syndrome: High Job Strain and Effort–Reward Imbalance at Work Associated With Arrhythmic Risk in the Long QT Syndrome by Hintsa, Taina, Määttänen, I., Hintsanen, M., Swan, H., Toivonen, L., Kontula, K., Keltikangas-Järvinen, L.

“…OBJECTIVES:To examine whether work stress is associated with a symptomatic status of the long QT syndrome (LQTS). METHODS:The sample comprised 173 KCNQ1,…”
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Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves by Paavola, Jere, Viitasalo, Matti, Laitinen-Forsblom, Päivi J., Pasternack, Michael, Swan, Heikki, Tikkanen, Ilkka, Toivonen, Lauri, Kontula, Kimmo, Laine, Mika

“…Aims Mutations in cardiac ryanodine receptors (RyR2s) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by risk of…”
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Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients by Parmar, A S, Lappalainen, M, Paavola-Sakki, P, Halme, L, Färkkilä, M, Turunen, U, Kontula, K, Aromaa, A, Salomaa, V, Peltonen, L, Halfvarson, J, Törkvist, L, D'Amato, M, Saavalainen, P, Einarsdottir, E

“…Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility…”
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A history of stressful life events, prolonged mental stress and arrhythmic events in inherited long QT syndrome by Hintsa, T, Puttonen, S, Toivonen, L, Kontula, K, Swan, H, Keltikangas-Järvinen, L

“…To examine whether a history of stressful life events and prolonged mental stress are associated with arrhythmic events in inherited long QT syndrome (LQTS)…”
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