Search Results - "Konttinen, Yrjo T"

Particle disease: biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty by Gallo, Jiri, Goodman, Stuart B, Konttinen, Yrjö T, Raska, Milan

“…Numerous studies provide detailed insight into the triggering and amplification mechanisms of the inflammatory response associated with prosthetic wear…”
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Macrophages-Key cells in the response to wear debris from joint replacements by Nich, Christophe, Takakubo, Yuya, Pajarinen, Jukka, Ainola, Mari, Salem, Abdelhakim, Sillat, Tarvo, Rao, Allison J., Raska, Milan, Tamaki, Yasunobu, Takagi, Michiaki, Konttinen, Yrjö T., Goodman, Stuart B., Gallo, Jiri

“…The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological…”
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Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis by Barreto, Goncalo, Soininen, Antti, Ylinen, Pekka, Sandelin, Jerker, Konttinen, Yrjö T, Nordström, Dan C, Eklund, Kari K

“…Soluble biglycan (sBGN) and soluble decorin (sDCN), are two closely related essential components of extracellular matrix which both have been shown to possess…”
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Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy by Ma, Yimin, Ren, Yongxin, Han, Ethan Q., Li, Huiwu, Chen, Di, Jacobs, Joshua J., Gitelis, Steven, O’Keefe, Regis J., Konttinen, Yrjö T., Yin, Guoyong, Li, Tian-Fang

“…► Wnt-β-catenin activated in osteosarcoma (OS). ► The level of β-catenin expression correlated with OS invasiveness. ► Suppressing β-catenin enhanced…”
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Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation by Sorsa, Timo, Tjäderhane, Leo, Konttinen, Yrjö T, Lauhio, Anneli, Salo, Tuula, Lee, Hsi-Ming, Golub, Lorne M, Brown, David L, Mäntylä, Päivi

“…Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions both in the tissue destruction and immune responses related to…”
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Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer by Al-Samadi, Ahmed, Moossavi, Shirin, Salem, Abdelhakim, Sotoudeh, Masoud, Tuovinen, Sarianna M., Konttinen, Yrjö T., Salo, Tuula, Bishehsari, Faraz

“…Colorectal cancer (CRC) is one of the most common cancers in both genders. Even though interleukin (IL)-17A was shown to play an important role in intestinal…”
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Patient reported outcome measures after revision of the infected TKR: comparison of single versus two-stage revision by Baker, Paul, Petheram, Timothy G., Kurtz, Steven, Konttinen, Yrjö T., Gregg, Paul, Deehan, David

“…Purpose Two-stage revision is the ‘gold standard’ treatment for infected total knee replacement. Single-stage revision has been successful in the hip and, in…”
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Modulation of mouse macrophage polarization in vitro using IL-4 delivery by osmotic pumps by Pajarinen, Jukka, Tamaki, Yasunobu, Antonios, Joseph K., Lin, Tzu-Hua, Sato, Taishi, Yao, Zhenyu, Takagi, Michiaki, Konttinen, Yrjö T., Goodman, Stuart B.

“…Modulation of macrophage polarization is emerging as promising means to mitigate wear particle‐induced inflammation and periprosthetic osteolysis. As a model…”
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Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum by Castrén, Eeva, Sillat, Tarvo, Oja, Sofia, Noro, Ariel, Laitinen, Anita, Konttinen, Yrjö T, Lehenkari, Petri, Hukkanen, Mika, Korhonen, Matti

“…Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering…”
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B-cells and their targeting in rheumatoid arthritis — Current concepts and future perspectives by Nakken, Britt, Munthe, Ludvig A, Konttinen, Yrjö T, Sandberg, Anna Klokk, Szekanecz, Zoltan, Alex, Philip, Szodoray, Peter

“…Abstract Rheumatoid arthritis (RA) is a chronic, autoimmune disease that affects primarily the joints and without proper treatment results in their progressive…”
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Differential influence of peripheral and systemic sex steroids on skeletal muscle quality in pre‐ and postmenopausal women by Pöllänen, Eija, Sipilä, Sarianna, Alen, Markku, Ronkainen, Paula H.A., Ankarberg‐Lindgren, Carina, Puolakka, Jukka, Suominen, Harri, Hämäläinen, Esa, Turpeinen, Ursula, Konttinen, Yrjö T., Kovanen, Vuokko

“…Summary Aging is associated with gradual decline of skeletal muscle strength and mass often leading to diminished muscle quality. This phenomenon is known as…”
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Sex steroids in Sjögren’s syndrome by Konttinen, Yrjö T, Fuellen, Georg, Bing, Yan, Porola, Pauliina, Stegaev, Vasily, Trokovic, Nina, Falk, Steffi S.I, Liu, Yi, Szodoray, Peter, Takakubo, Yuya

“…Abstract The purpose of the review is to consider pathomechanisms of Sjögren’s syndrome (SS), which could explain the female dominance (9:1), the most common…”
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Established and novel approaches for the management of hyposalivation and xerostomia by Wolff, Andy, Fox, Philip C, Porter, Stephen, Konttinen, Yrjo T

“…Hyposalivation, often symptomatically manifested as xerostomia (dry mouth sensation) may indicate the presence of altered salivary gland function and places…”
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Innate immune reactions in septic and aseptic osteolysis around hip implants by Pajarinen, Jukka, Jamsen, Eemeli, Konttinen, Yrjo T, Goodman, Stuart B

“…According to the long-standing definition, septic and aseptic total joint replacement loosening are two distinct conditions with little in common. Septic joint…”
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Cartilage repair: past and future – lessons for regenerative medicine by Van Osch, Gerjo J. V. M., Brittberg, Mats, Dennis, James E., Bastiaansen‐Jenniskens, Yvonne M., Erben, Reinhold G., Konttinen, Yrjö T., Luyten, Frank P.

“…•  Introduction: the impaired repair capacity of cartilage and the beginning of cell therapy ‐  Autologous chondrocyte implantation ‐  Combination products ‐ …”
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Biocompatibility of total joint replacements: A review by Goodman, Stuart B., Gómez Barrena, Enrique, Takagi, Michiaki, Konttinen, Yrjo T.

“…Total joint replacement is one of the most clinically successful, cost‐effective surgical procedures. These operations have been shown to improve pain,…”
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Adhesion, spreading and osteogenic differentiation of mesenchymal stem cells cultured on micropatterned amorphous diamond, titanium, tantalum and chromium coatings on silicon by Myllymaa, Sami, Kaivosoja, Emilia, Myllymaa, Katja, Sillat, Tarvo, Korhonen, Hannu, Lappalainen, Reijo, Konttinen, Yrjö T.

“…It was hypothesized that human mesenchymal stromal cell (hMSC) can be guided by patterned and plain amorphous diamond (AD), titanium (Ti), tantalum (Ta) and…”
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Human beta-defensin-3 producing cells in septic implant loosening by Levón, Jaakko, Al-Samadi, Ahmed, Mackiewicz, Zygmunt, Coer, Andrej, Trebse, Rihard, Waris, Eero, Konttinen, Yrjö T.

“…Human β-defensin-3 (hBD-3) has been found in synovial fluid and later in periprosthetic tissues in septic joint implant loosening. The aim of the present study…”
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IL-17C and its receptor IL-17RA/IL-17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer by Al-Samadi, Ahmed, Kouri, Vesa-Petteri, Salem, Abdelhakim, Ainola, Mari, Kaivosoja, Emilia, Barreto, Gonçalo, Konttinen, Yrjö T., Hietanen, Jarkko, Häyrinen-Immonen, Ritva

“…Background Recurrent aphthous ulcer (RAU) is an ulcerative disease of non‐keratinized oral mucosa. Colon and bronchial epithelial cells produce interleukin‐17C…”
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Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression by Caetano-Lopes, Joana, Rodrigues, Ana, Lopes, Ana, Vale, Ana C., Pitts-Kiefer, Michael A., Vidal, Bruno, Perpétuo, Inês P., Monteiro, Jacinto, Konttinen, Yrjö T., Vaz, Maria F., Nazarian, Ara, Canhão, Helena, Fonseca, João E.

“…Our aim was to compare bone gene expression in rheumatoid arthritis (RA) and primary osteoporosis (OP) patients. Secondary aims were to determine the…”
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