Search Results - "Konttinen, Yrjö T."

The cost-effectiveness of biologics for the treatment of rheumatoid arthritis: a systematic review by Joensuu, Jaana T, Huoponen, Saara, Aaltonen, Kalle J, Konttinen, Yrjö T, Nordström, Dan, Blom, Marja

“…Economic evaluations provide information to aid the optimal utilization of limited healthcare resources. Costs of biologics for Rheumatoid arthritis (RA) are…”
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Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis by Aaltonen, Kalle J, Virkki, Liisa M, Malmivaara, Antti, Konttinen, Yrjö T, Nordström, Dan C, Blom, Marja

“…Five-tumour necrosis factor (TNF)-blockers (infliximab, etanercept, adalimumab, certolizumab pegol and golimumab) are available for treatment of rheumatoid…”
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Younger age increases the risk of early prosthesis failure following primary total knee replacement for osteoarthritis: A follow-up study of 32,019 total knee replacements in the Finnish Arthroplasty Register by Julin, Jaakko, Jämsen, Esa, Puolakka, Timo, Konttinen, Yrjö T, Moilanen, Teemu

“…Background and purpose Total knee replacements (TKRs) are being increasingly performed in patients aged ≤ 65 years who often have high physical demands. We…”
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The response of macrophages to titanium particles is determined by macrophage polarization by Pajarinen, Jukka, Kouri, Vesa-Petteri, Jämsen, Eemeli, Li, Tian-Fang, Mandelin, Jami, Konttinen, Yrjö T.

“…Aseptic loosening of total joint replacements is driven by the reaction of macrophages to foreign body particles released from the implant. It was hypothesized…”
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Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hip replacement by Gallo, Jiri, Vaculova, Jana, Goodman, Stuart B., Konttinen, Yrjö T., Thyssen, Jacob P.

“…[Display omitted] Aseptic loosening and osteolysis are the most frequent late complications of total hip arthroplasty (THA) leading to revision of the…”
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Establishment of Green Fluorescent Protein and Firefly Luciferase Expressing Mouse Primary Macrophages for In Vivo Bioluminescence Imaging by Pajarinen, Jukka, Lin, Tzu-Hua, Sato, Taishi, Loi, Florence, Yao, Zhenyu, Konttinen, Yrjö T, Goodman, Stuart B

“…Macrophages play a key role in tissue homeostasis as well as in a range of pathological conditions including atherosclerosis, cancer, and autoimmunity. Many…”
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Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis by Olkkonen, Juri, Kouri, Vesa-Petteri, Hynninen, Joel, Konttinen, Yrjö T, Mandelin, Jami

“…Patients with rheumatoid arthritis (RA) have altered circadian rhythm of circulating serum cortisol, melatonin and IL-6, as well as disturbance in the…”
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Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level by Kouri, Vesa-Petteri, Olkkonen, Juri, Kaivosoja, Emilia, Ainola, Mari, Juhila, Juuso, Hovatta, Iiris, Konttinen, Yrjö T, Mandelin, Jami

“…Patients with rheumatoid arthritis (RA) have disturbances in the hypothalamic-pituitary-adrenal (HPA) axis. These are reflected in altered circadian rhythm of…”
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Expression of Toll-like Receptors and Their Signaling Pathways in Rheumatoid Synovitis by TAMAKI, Yasunobu, TAKAKUBO, Yuya, HIRAYAMA, Tomoyuki, KONTTINEN, Yrjo T, GOODMAN, Stuart B, YAMAKAWA, Mitsunori, TAKAGI, Michiaki

“…Toll-like receptors (TLR) recognizing endogenous and exogenous danger signals could play a role in rheumatoid arthritis (RA). Our aim was to describe the…”
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Chemical and physical properties of regenerative medicine materials controlling stem cell fate by Kaivosoja, Emilia, Barreto, Gonçalo, Levón, Kalle, Virtanen, Sannakaisa, Ainola, Mari, Konttinen, Yrjö T

“…Regenerative medicine is a multidisciplinary field utilizing the potential of stem cells and the regenerative capability of the body to restore, maintain, or…”
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Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology by Gómez‐Barrena, Enrique, Rosset, Philippe, Müller, Ingo, Giordano, Rosaria, Bunu, Carmen, Layrolle, Pierre, Konttinen, Yrjö T., Luyten, Frank P.

“…•  Introduction •  Characterization of cells for bone regeneration in human beings •  State of the art in bone tissue engineering ‐  Biomaterials for…”
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Characterization of macrophage polarizing cytokines in the aseptic loosening of total hip replacements by Jämsen, Eemeli, Kouri, Vesa-Petteri, Olkkonen, Juri, Cör, Andrej, Goodman, Stuart B., Konttinen, Yrjö T., Pajarinen, Jukka

“…ABSTRACT Aseptic loosening of hip replacements is driven by the macrophage reaction to wear particles. The extent of particle‐induced macrophage activation is…”
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Basement membrane collagen type IV expression by human mesenchymal stem cells during adipogenic differentiation by Sillat, Tarvo, Saat, Riste, Pöllänen, Raimo, Hukkanen, Mika, Takagi, Michiaki, Konttinen, Yrjö T.

“…During adipogenic differentiation human mesenchymal stem cells (hMSC) produce collagen type IV. In immunofluorescence staining differentiating hMSCs started to…”
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Surgery: Adverse reactions to metal-on-metal implants by Konttinen, Yrjö T, Pajarinen, Jukka

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The effect of pulsed electromagnetic fields and dehydroepiandrosterone on viability and osteo-induction of human mesenchymal stem cells by Kaivosoja, Emilia, Sariola, Veikko, Chen, Yan, Konttinen, Yrjö T.

“…The hypothesis of this work was that human bone marrow‐derived mesenchymal stem cells (MSCs) are regulated by pulsed electromagnetic fields (PEMFs) and by…”
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Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces by Kaivosoja, Emilia, Suvanto, Pia, Barreto, Gonçalo, Aura, Susanna, Soininen, Antti, Franssila, Sami, Konttinen, Yrjö T.

“…We hypothesized that when compared with conventional two‐dimensional (2D) cultures, substrates containing 3D micropillars would allow cells to grow at levels,…”
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Laminin Production and Basement Membrane Deposition by Mesenchymal Stem Cells upon Adipogenic Differentiation by Noro, Ariel, Sillat, Tarvo, Virtanen, Ismo, Ingerpuu, Sulev, Bäck, Nils, Konttinen, Yrjö T., Korhonen, Matti

“…The aim was to study laminin (LM) synthesis, integration, and deposition into the basement membrane (BM) during adipogenesis. Human bone marrow-derived…”
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Incidence of Prosthetic Joint Infections After Primary Knee Arthroplasty by Jämsen, Esa, BM, Varonen, Markku, BM, Huhtala, Heini, MSc, Lehto, Matti U.K., MD, PhD, Lumio, Jukka, MD, PhD, Konttinen, Yrjö T., MD, PhD, Moilanen, Teemu, MD, PhD

“…Abstract We report the 1-year incidence of postoperative infections in an unselected series of 2647 consecutive primary knee arthroplasties (3137 knees)…”
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Toll-like receptors in human chondrocytes and osteoarthritic cartilage by Sillat, Tarvo, Barreto, Gonçalo, Clarijs, Paul, Soininen, Antti, Ainola, Mari, Pajarinen, Jukka, Korhonen, Matti, Konttinen, Yrjö T, Sakalyte, Regina, Hukkanen, Mika, Ylinen, Pekka, Nordström, Dan C E

“…Background and purpose Degenerating cartilage releases potential danger signals that react with Toll-like receptor (TLR) type danger receptors. We investigated…”
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Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach: A systematic review of the literature by Jämsen, Esa, Stogiannidis, Ioannis, Malmivaara, Antti, Pajamäki, Jorma, Puolakka, Timo, Konttinen, Yrjö T

“…Background and purpose Two-stage revision remains the gold standard in the treatment of infected knee arthroplasty. Lately, good long-term results of direct…”
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