Search Results - "Konttinen, Y."

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms by Gallo, J., Goodman, S.B., Konttinen, Y.T., Wimmer, M.A., Holinka, M.

“…Aseptic loosening and other wear-related complications are some of the most frequent late reasons for revision of total knee arthroplasty (TKA). Periprosthetic…”
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Bone regeneration and stem cells by Arvidson, K., Abdallah, B. M., Applegate, L. A., Baldini, N., Cenni, E., Gomez‐Barrena, E., Granchi, D., Kassem, M., Konttinen, Y. T., Mustafa, K., Pioletti, D. P., Sillat, T., Finne‐Wistrand, A.

“…•  Introduction •  Bone fracture healing and healing problems •  Biomaterial scaffolds and tissue engineering in bone formation ‐  Bone tissue engineering ‐ …”
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MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis by Beklen, A., Ainola, M., Hukkanen, M., Gürgan, C., Sorsa, T., Konttinen, Y.T.

“…Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1β and tumor necrosis…”
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Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement by Goodman, S. B., Gibon, E., Pajarinen, J., Lin, T.-H., Keeney, M., Ren, P.-G., Nich, C., Yao, Z., Egashira, K., Yang, F., Konttinen, Y. T.

“…Wear particles and by-products from joint replacements and other orthopaedic implants may result in a local chronic inflammatory and foreign body reaction…”
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Special modes of corrosion under physiological and simulated physiological conditions by Virtanen, S., Milošev, I., Gomez-Barrena, E., Trebše, R., Salo, J., Konttinen, Y.T.

“…The aim of this article is to review those aspects of corrosion behaviour that are most relevant to the clinical application of implant alloys. The special…”
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Blood vessels of human islets of Langerhans are surrounded by a double basement membrane by Virtanen, I, Banerjee, M, Palgi, J, Korsgren, O, Lukinius, A, Thornell, L.-E, Kikkawa, Y, Sekiguchi, K, Hukkanen, M, Konttinen, Y. T, Otonkoski, T

“…Aims/hypothesis Based on mouse study findings, pancreatic islet cells are supposed to lack basement membrane (BM) and interact directly with vascular…”
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Regulation of macrophage activation by Ma, J, Chen, T, Mandelin, J, Ceponis, A, Miller, N E, Hukkanen, M, Ma, G F, Konttinen, Y T

“…IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T…”
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Expression of cathepsin K in periodontitis and in gingival fibroblasts by Beklen, A, Al-Samadi, A, Konttinen, YT

“…Objective To study non‐osteoclastic sources of cathepsin K in periodontitis. Materials and Methods Tissue samples were obtained from 10 otherwise healthy…”
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Recurrent aphthous ulcers today: a review of the growing knowledge by Natah, S.S., Konttinen, Y.T., Enattah, N.S., Ashammakhi, N., Sharkey, K.A., Häyrinen-Immonen, R.

“…Recurrent aphthous ulcers represent a very common but poorly understood mucosal disorder. They occur in men and women of all ages, races and geographic…”
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RANKL in the osteolysis of AES total ankle replacement implants by Koivu, H, Mackiewicz, Z, Takakubo, Y, Trokovic, N, Pajarinen, J, Konttinen, Y.T

“…Abstract Peri-implant tissue reactions in failed total ankle replacement (TAR) are characterized by early developing peri-implant osteolysis. The hypothesis of…”
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Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis by Konttinen, Yrjö T, Ainola, Mia, Valleala, Heikki, Ma, Jian, Ida, Hideo, Mandelin, Jami, Kinne, Raimund W, Santavirta, Seppo, Sorsa, Timo, López-Otín, Carlos, Takagi, Michiaki

“…OBJECTIVE To define the pattern of mRNA expression of all human matrix metalloproteinases (MMPs) described to date in rheumatoid arthritis (RA) and traumatic…”
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High mobility group box-1 (HMGB-1) in osteoarthritic cartilage by HEINOLA, T, KOURI, V.-P, CLARIJS, P, CIFERSKA, H, SUKURA, A, SALO, J, KONTTINEN, Y. T

“…Nucleosomal high mobility group box-1 (HMGB-1) is translocated and released from necrotic and activated cells as an endogenous danger signal (alarmin) and…”
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Epithelial Cell Apoptosis in Recurrent Aphthous Ulcers by Al-Samadi, A., Drozd, A., Salem, A., Hietanen, J., Häyrinen-Immonen, R., Konttinen, Y.T.

“…A recurrent aphthous ulcer (RAU) is a common inflammatory ulcerative lesion affecting oral mucosa. We studied the eventual apoptosis of epithelial cells from…”
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Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction by Ainola, M, Li, T-F, Mandelin, J, Hukkanen, M, Choi, S J, Salo, J, Konttinen, Y T

“…The eventual role of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis was studied in erosive rheumatoid arthritis (RA) and in vitro. ADAM8…”
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Effect of S53P4 bone substitute on staphylococcal adhesion and biofilm formation on other implant materials in normal and hypoxic conditions by Pérez-Tanoira, R., García-Pedrazuela, M., Hyyrynen, T., Soininen, A., Aarnisalo, A., Nieminen, Mikko T., Tiainen, V.-M., Konttinen, Y. T., Kinnari, T. J.

“…To study the effect of bioactive glass bone substitute granules (S53P4) on bacterial adhesion and biofilm formation on other simultaneously used implant…”
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Histamine H4 receptor in oral lichen planus by Salem, A, Al-Samadi, A, Stegajev, V, Stark, H, Häyrinen-Immonen, R, Ainola, M, Hietanen, J, Konttinen, YT

“…Objectives Oral lichen planus (OLP) is an autoimmune disease characterized by a band‐like T‐cell infiltrate below the apoptotic epithelial cells and…”
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Tumor targeting with a selective gelatinase inhibitor by Koivunen, Erkki, Pasqualini, Renata, Arap, Wadih, Valtanen, Heli, Rainisalo, Aija, Medina, Oula Penate, Heikkilä, Pia, Kantor, Carmela, Gahmberg, Carl G, Salo, Tuula, Konttinen, Yrjö T, Sorsa, Timo, Ruoslahti, Erkki

“…Several lines of evidence suggest that tumor growth, angiogenesis, and metastasis are dependent on matrix metalloproteinase (MMP) activity. However, the lack…”
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Sjögren’s syndome and extragonadal sex steroid formation: A clue to a better disease control? by Konttinen, Y.T., Stegajev, V., Al-Samadi, A., Porola, P., Hietanen, J., Ainola, M.

“…•Salivary gland epithelial cells produce by and for themselves DHT using intracrine enzymes.•Menopause increases the need for intracrine DHEA-DHT conversion in…”
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BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway by Li, T.-F, Yukata, K, Yin, G, Sheu, T, Maruyama, T, Jonason, J.H, Hsu, W, Zhang, X, Xiao, G, Konttinen, Y.T, Chen, D, O'Keefe, R.J

“…Summary Objective Bone morphogenic protein (BMP)-2 is approved for fracture non-union and spine fusion. We aimed to further dissect its downstream signaling…”
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Diminished salivary epidermal growth factor secretion: a link between Sjögren's syndrome and autoimmune gastritis? by Koskenpato, K, Ainola, M, Przybyla, B, Kouri, V-P, Virkki, L, Koskenpato, J, Ristimäki, A, Konttinen, YT

“…Objectives: Healthy human labial salivary glands produce epidermal growth factor (EGF). In Sjögren's syndrome (SS), EGF staining is diminished. SS is also…”
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