Search Results - "Kontseková, Eva"

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans by Weisová, Petronela, Cehlár, Ondrej, Škrabana, Rostislav, Žilková, Monika, Filipčík, Peter, Kováčech, Branislav, Prčina, Michal, Wojčiaková, Ľubica, Fialová, Ľubica, Smolek, Tomáš, Kontseková, Eva, Žilka, Norbert, Novák, Michal

“…Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer's disease (AD) and other tauopathies. Therefore,…”
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Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead by Novak, Petr, Kontsekova, Eva, Zilka, Norbert, Novak, Michal

“…Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is…”
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First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model by Kontsekova, Eva, Zilka, Norbert, Kovacech, Branislav, Novak, Petr, Novak, Michal

“…We have identified structural determinants on tau protein that are essential for pathological tau-tau interaction in Alzheimer's disease (AD). These regulatory…”
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A walk through tau therapeutic strategies by Jadhav, Santosh, Avila, Jesus, Schöll, Michael, Kovacs, Gabor G, Kövari, Enikö, Skrabana, Rostislav, Evans, Lewis D, Kontsekova, Eva, Malawska, Barbara, de Silva, Rohan, Buee, Luc, Zilka, Norbert

“…Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence…”
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Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial by Novak, Petr, Dr, Schmidt, Reinhold, Prof, Kontsekova, Eva, Prof, Zilka, Norbert, PhD, Kovacech, Branislav, PhD, Skrabana, Rostislav, PhD, Vince-Kazmerova, Zuzana, PhD, Katina, Stanislav, PhD, Fialova, Lubica, PhD, Prcina, Michal, PhD, Parrak, Vojtech, MD, Dal-Bianco, Peter, MD, Brunner, Martin, MD, Staffen, Wolfgang, MD, Rainer, Michael, MD, Ondrus, Matej, MD, Ropele, Stefan, Ing, Smisek, Miroslav, MD, Sivak, Roman, Ing, Winblad, Bengt, Prof, Novak, Michal, Prof

“…Summary Background Neurofibrillary pathology composed of tau protein is a main correlate of cognitive impairment in patients with Alzheimer's disease…”
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Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias by Hanes, Jozef, Kovac, Andrej, Kvartsberg, Hlin, Kontsekova, Eva, Fialova, Lubica, Katina, Stanislav, Kovacech, Branislav, Stevens, Eva, Hort, Jakub, Vyhnalek, Martin, Boonkamp, Lynn, Novak, Michal, Zetterberg, Henrik, Hansson, Oskar, Scheltens, Philip, Blennow, Kaj, Teunissen, Charlotte E., Zilka, Norbert

“…OBJECTIVETo investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with…”
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FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease by Novak, Petr, Schmidt, Reinhold, Kontsekova, Eva, Kovacech, Branislav, Smolek, Tomas, Katina, Stanislav, Fialova, Lubica, Prcina, Michal, Parrak, Vojtech, Dal-Bianco, Peter, Brunner, Martin, Staffen, Wolfgang, Rainer, Michael, Ondrus, Matej, Ropele, Stefan, Smisek, Miroslav, Sivak, Roman, Zilka, Norbert, Winblad, Bengt, Novak, Michal

“…Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with Alzheimer's…”
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Truncated tau from sporadic Alzheimer’s disease suffices to drive neurofibrillary degeneration in vivo by Zilka, Norbert, Filipcik, Peter, Koson, Peter, Fialova, Lubica, Skrabana, Rostislav, Zilkova, Monika, Rolkova, Gabriela, Kontsekova, Eva, Novak, Michal

“…Truncated tau protein is the characteristic feature of human sporadic Alzheimer’s disease. We have identified truncated tau proteins conformationally different…”
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Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217 by Kovacech, Branislav, Cullen, Nicholas C., Novak, Petr, Hanes, Jozef, Kontsekova, Eva, Katina, Stanislav, Parrak, Vojtech, Fresser, Michal, Vanbrabant, Jeroen, Feldman, Howard H., Winblad, Bengt, Stoops, Erik, Vanmechelen, Eugeen, Zilka, Norbert

“…Background The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer's disease (AD). Tau-targeting…”
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Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation by Zilkova, Monika, Nolle, Anna, Kovacech, Branislav, Kontsekova, Eva, Weisova, Petronela, Filipcik, Peter, Skrabana, Rostislav, Prcina, Michal, Hromadka, Tomas, Cehlar, Ondrej, Rolkova, Gabriela Paulikova, Maderova, Denisa, Novak, Michal, Zilka, Norbert, Hoozemans, Jeroen J M

“…Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously…”
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Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern by Kovacech, Branislav, Fialova, Lubica, Filipcik, Peter, Skrabana, Rostislav, Zilkova, Monika, Paulenka-Ivanovova, Natalia, Kovac, Andrej, Palova, Denisa, Rolkova, Gabriela Paulikova, Tomkova, Katarina, Csokova, Natalia Turic, Markova, Karina, Skrabanova, Michaela, Sinska, Kristina, Basheer, Neha, Majerova, Petra, Hanes, Jozef, Parrak, Vojtech, Prcina, Michal, Cehlar, Ondrej, Cente, Martin, Piestansky, Juraj, Fresser, Michal, Novak, Michal, Slavikova, Monika, Borsova, Kristina, Cabanova, Viktoria, Brejova, Bronislava, Vinař, Tomas, Nosek, Jozef, Klempa, Boris, Eyer, Ludek, Hönig, Vaclav, Palus, Martin, Ruzek, Daniel, Vyhlidalova, Tereza, Strakova, Petra, Mrazkova, Blanka, Zudova, Dagmar, Koubkova, Gizela, Novosadova, Vendula, Prochazka, Jan, Sedlacek, Radislav, Zilka, Norbert, Kontsekova, Eva

“…The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S…”
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Fundamental and Advanced Therapies, Vaccine Development against SARS-CoV-2 by Hudakova, Nikola, Hricikova, Simona, Kulkarni, Amod, Bhide, Mangesh, Kontsekova, Eva, Cizkova, Dasa

“…Coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has been affecting the world since the end of 2019. The severity of the disease can range from an…”
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Structure solution of misfolded conformations adopted by intrinsically disordered Alzheimer's tau protein by Sevcik, Jozef, Skrabana, Rostislav, Kontsekova, Eva, Novak, Michal

“…Until now it was impossible to obtain atomic structure of intrinsically disordered protein (IDP) tau and/or its assembly in Alzheimer's paired helical…”
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High-yield purification of fetal tau preserving its structure and phosphorylation pattern by Ivanovova, Natalia, Handzusova, Martina, Hanes, Jozef, Kontsekova, Eva, Novak, Michal

“…The fetal type of tau phosphorylation always re-appears during pathogenesis of Alzheimer's disease and related tauopathies. The major obstacle in the study of…”
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Generation, accumulation and degradation of aberrant tau proteins in cortical neurons of transgenic rat during pathogenesis of chronic neurodegenerative disease by Filipcik, Peter, Krajciova, Gabriela, Cente, Martin, Skrabana, Rostislav, Kovacech, Branislav, Kontsekova, Eva, Novak, Michal

“…Increased accumulation of misfolded proteins in neurons of central nervous system is a typical feature of tauopathies including Alzheimer's disease (AD). Our…”
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Study of local anaesthetics: part 204 determination of critical micelle concentrations of selected derivatives of pyrrolidino-m-alkoxyphenylcarbamic acid using pyrene as a probe by Gališinová, Jana, Andriamainty, Fils, Cižmárik, Jozef, Kontseková, Eva, Malík, Ivan

“…The critical micelle concentrations of the studied derivatives of pyrrolidino-m-alkoxyphenylcarbamic acid in aqueous media at 25 °C were determined using the…”
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Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease by Kontsekova, Eva, Zilka, Norbert, Kovacech, Branislav, Skrabana, Rostislav, Novak, Michal

“…Pathologically modified tau protein is the main feature of Alzheimer's disease (AD) and related tauopathies. Therefore, immunotherapies that target…”
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A rapid immunohistochemical primary screening assay for hybridomas by ZILKA, Norbert, VECHTEROVA, L'Uba, KONTSEKOVA, Eva, NOVAK, Michal

“…A primary screening of monoclonal antibodies (mAbs) prepared by hybridoma technology requires the testing of a large number of hybridoma culture supernatants…”
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Tauons and prions: infamous cousins? by Novak, Petr, Prcina, Michal, Kontsekova, Eva

“…The paradigm of Alzheimer's disease (AD) is one subject to frequent change: what was thought to be a rare form of pre-senile dementia was revealed as a…”
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The immunology of the first tau vaccine for Alzheimer’s disease therapy: new findings and challenges by Žilka, Norbert, Novak, Petr, Katina, Stanislav, Kontsekova, Eva

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