Search Results - "Kontermann, Roland E."

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach by Fischer, Roman, Kontermann, Roland E., Pfizenmaier, Klaus

“…Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-inflammatory effects, drugs that neutralize TNF were developed and are…”
Get full text

GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments by Seifert, Oliver, Kontermann, Roland E

“…Many therapeutic proteins are small in size and are rapidly cleared from circulation. Consequently, half-life extension strategies have emerged to improve…”
Get full text

OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models by Fabre, Myriam, Ferrer, Cristina, Domínguez-Hormaetxe, Saioa, Bockorny, Bruno, Murias, Laura, Seifert, Oliver, Eisler, Stephan A, Kontermann, Roland E, Pfizenmaier, Klaus, Lee, So Young, Vivanco, María dM, López-Casas, Pedro P, Perea, Sofia, Abbas, Muhammad, Richter, Wolfgang, Simon, Laureano, Hidalgo, Manuel

“…The tumor microenvironment plays a key role in cancer development and progression and is involved in resistance to chemo- and immunotherapy. Cancer-associated…”
Get full text

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration by Dong, Yun, Fischer, Roman, Naudé, Petrus J. W., Maier, Olaf, Nyakas, Csaba, Duffey, Maëlle, Van der Zee, Eddy A., Dekens, Doortje, Douwenga, Wanda, Herrmann, Andreas, Guenzi, Eric, Kontermann, Roland E., Pfizenmaier, Klaus, Eisel, Ulrich L. M.

“…Despite the recognized role of tumor necrosis factor (TNF) in inflammation and neuronal degeneration, anti-TNF therapeutics failed to treat neurodegenerative…”
Get full text

The eIg technology to generate Ig-like bispecific antibodies by Kühl, Lennart, Aschmoneit, Nadine, Kontermann, Roland E, Seifert, Oliver

“…Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve…”
Get full text

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice by Papazian, Irini, Tsoukala, Eleni, Boutou, Athena, Karamita, Maria, Kambas, Konstantinos, Iliopoulou, Lida, Fischer, Roman, Kontermann, Roland E, Denis, Maria C, Kollias, George, Lassmann, Hans, Probert, Lesley

“…During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates…”
Get full text

The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration by Ortí-Casañ, Natalia, Boerema, Ate S., Köpke, Karina, Ebskamp, Amber, Keijser, Jan, Zhang, Yuequ, Chen, Tingting, Dolga, Amalia M., Broersen, Kerensa, Fischer, Roman, Pfizenmaier, Klaus, Kontermann, Roland E., Eisel, Ulrich L. M.

“…Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and…”
Get full text

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice by Unverdorben, Felix, Richter, Fabian, Hutt, Meike, Seifert, Oliver, Malinge, Pauline, Fischer, Nicolas, Kontermann, Roland E

“…Fusion to an IgG Fc region is an established strategy to extend the half-life of therapeutic proteins. Most Fc fusion proteins, however, do not achieve the…”
Get full text

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis by Fischer, Roman, Proske, Marcel, Duffey, Maëlle, Stangl, Hubert, Martinez, George F., Peters, Nathalie, Kraske, Alexandra, Straub, Rainer H., Bethea, John R., Kontermann, Roland E., Pfizenmaier, Klaus

“…Objective Treg cells modulate immune responses and can suppress the development of autoimmune diseases. Tumor necrosis factor receptor II (TNFRII) has been…”
Get full text

A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells by Aschmoneit, Nadine, Steinlein, Sophia, Kühl, Lennart, Seifert, Oliver, Kontermann, Roland E.

“…HER3 is a member of the EGF receptor family and elevated expression is associated with cancer progression and therapy resistance. HER3-specific T-cell engagers…”
Get full text

Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis by Nguyen, Kayla L., Bhatt, Ishaan J., Gupta, Shruti, Showkat, Nazaf, Swanson, Kathryn A., Fischer, Roman, Kontermann, Roland E., Pfizenmaier, Klaus, Bracchi-Ricard, Valerie, Bethea, John R.

“…Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor…”
Get full text

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma by Krishna Moorthy, Nivetha, Seifert, Oliver, Eisler, Stephan, Weirich, Sara, Kontermann, Roland E, Rehm, Markus, Fullstone, Gavin

“…Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor…”
Get full text

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis by Fiedler, Timon, Fairless, Richard, Pichi, Kira, Fischer, Roman, Richter, Fabian, Kontermann, Roland E, Pfizenmaier, Klaus, Diem, Ricarda, Williams, Sarah K

“…Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing…”
Get full text

eIg-based bispecific T-cell engagers targeting EGFR: Format matters by Kühl, Lennart, Schäfer, Annelie K, Kraft, Sebastian, Aschmoneit, Nadine, Kontermann, Roland E, Seifert, Oliver

“…Bispecific antibodies are molecules with versatile modes of action and applications for therapy. They are commonly developed as T-cell engagers (TCE), which…”
Get full text

Strategies for extended serum half-life of protein therapeutics by Kontermann, Roland E

“…Highlights ► New biodegradable polymers, for example, flexible polypeptide chains, are being developed as a substitute for PEGylation. ► Fusion to the IgG Fc…”
Get full text

Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics by Kontermann, Roland E., Ungerechts, Guy, Nettelbeck, Dirk M.

“…Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular…”
Get full text

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2 by Fischer, Roman, Marsal, Jessica, Guttà, Cristiano, Eisler, Stephan A., Peters, Nathalie, Bethea, John R., Pfizenmaier, Klaus, Kontermann, Roland E.

“…Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor…”
Get full text

The making of bispecific antibodies by Brinkmann, Ulrich, Kontermann, Roland E.

“…During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications. The 'zoo' of bispecific antibodies is…”
Get full text

Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc) by Aschmoneit, Nadine, Kocher, Katharina, Siegemund, Martin, Lutz, Martina S., Kühl, Lennart, Seifert, Oliver, Kontermann, Roland E.

“…Targeting costimulatory receptors of the tumor necrosis factor superfamily (TNFSF) to activate T-cells and promote anti-tumor T-cell function have emerged as a…”
Get full text

Bispecific antibodies by Kontermann, Roland E., Brinkmann, Ulrich

“…Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously address different antigens or epitopes. BsAbs with ‘two-target’…”
Get full text