Search Results - "Konstantinović, Jelena"

N‑Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases by Konstantinović, Jelena, Yahiaoui, Samir, Alhayek, Alaa, Haupenthal, Jörg, Schönauer, Esther, Andreas, Anastasia, Kany, Andreas M, Müller, Rolf, Koehnke, Jesko, Berger, Fabian K, Bischoff, Markus, Hartmann, Rolf W, Brandstetter, Hans, Hirsch, Anna K. H

“…In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes of action. It has…”
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N -Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases by Kaya, Cansu, Konstantinović, Jelena, Kany, Andreas M, Andreas, Anastasia, Kramer, Jan S, Brunst, Steffen, Weizel, Lilia, Rotter, Marco J, Frank, Denia, Yahiaoui, Samir, Müller, Rolf, Hartmann, Rolf W, Haupenthal, Jörg, Proschak, Ewgenij, Wichelhaus, Thomas A, Hirsch, Anna K H

“…Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are…”
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Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections by Konstantinović, Jelena, Kany, Andreas M., Alhayek, Alaa, Abdelsamie, Ahmed S., Sikandar, Asfandyar, Voos, Katrin, Yao, Yiwen, Andreas, Anastasia, Shafiei, Roya, Loretz, Brigitta, Schönauer, Esther, Bals, Robert, Brandstetter, Hans, Hartmann, Rolf W., Ducho, Christian, Lehr, Claus-Michael, Beisswenger, Christoph, Müller, Rolf, Rox, Katharina, Haupenthal, Jörg, Hirsch, Anna K.H.

“…Infections caused by the Gram-negative pathogen Pseudomonas aeruginosa are emerging worldwide as a major threat to human health. Conventional antibiotic…”
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Reinvestigating Old Pharmacophores: Are 4‑Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? by Terzić, Natasa, Konstantinović, Jelena, Tot, Mikloš, Burojević, Jovana, Djurković-Djaković, Olgica, Srbljanović, Jelena, Štajner, Tijana, Verbić, Tatjana, Zlatović, Mario, Machado, Marta, Albuquerque, Inês S, Prudêncio, Miguel, Sciotti, Richard J, Pecic, Stevan, D’Alessandro, Sarah, Taramelli, Donatella, Šolaja, Bogdan A

“…The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited…”
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New Steroidal 4‑Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model by Konstantinović, Jelena, Kiris, Erkan, Kota, Krishna P, Kugelman-Tonos, Johanny, Videnović, Milica, Cazares, Lisa H, Terzić Jovanović, Nataša, Verbić, Tatjana Ž, Andjelković, Boban, Duplantier, Allen J, Bavari, Sina, Šolaja, Bogdan A

“…The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various…”
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Structure-Based Design of α‑Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa by Kaya, Cansu, Walter, Isabell, Alhayek, Alaa, Shafiei, Roya, Jézéquel, Gwenaëlle, Andreas, Anastasia, Konstantinović, Jelena, Schönauer, Esther, Sikandar, Asfandyar, Haupenthal, Jörg, Müller, Rolf, Brandstetter, Hans, Hartmann, Rolf W., Hirsch, Anna K.H.

“…Antivirulence therapy has become a widely applicable method for fighting infections caused by multidrug-resistant bacteria. Among the many virulence factors…”
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Second Generation Steroidal 4‑Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria by Videnović, Milica, Opsenica, Dejan M, Burnett, James C, Gomba, Laura, Nuss, Jonathan E, Selaković, Života, Konstantinović, Jelena, Krstić, Maja, Šegan, Sandra, Zlatović, Mario, Sciotti, Richard J, Bavari, Sina, Šolaja, Bogdan A

“…Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain…”
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Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB by Metelkina, Olga, Konstantinović, Jelena, Klein, Andreas, Shafiei, Roya, Fares, Mario, Alhayek, Alaa, Yahiaoui, Samir, Elgaher, Walid A M, Haupenthal, Jörg, Titz, Alexander, Hirsch, Anna K H

“…Dual inhibitors of two key virulence factors of , the lectin LecA and the protease LasB, open up an opportunity in the current antimicrobial-resistance crisis…”
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Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors by Kaya, Cansu, Walter, Isabell, Yahiaoui, Samir, Sikandar, Asfandyar, Alhayek, Alaa, Konstantinović, Jelena, Kany, Andreas M., Haupenthal, Jörg, Köhnke, Jesko, Hartmann, Rolf W., Hirsch, Anna K. H.

“…Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram‐negative pathogen Pseudomonas…”
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Human serum albumin binding of certain antimalarials by Marković, Olivera S., Cvijetić, Ilija N., Zlatović, Mario V., Opsenica, Igor M., Konstantinović, Jelena M., Terzić Jovanović, Nataša V., Šolaja, Bogdan A., Verbić, Tatjana Ž.

“…Interactions between eight in-house synthesized aminoquinolines, along with well-known chloroquine, and human serum albumin (HSA) have been studied by…”
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4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania by Manzano, José Ignacio, Konstantinović, Jelena, Scaccabarozzi, Diletta, Perea, Ana, Pavić, Aleksandar, Cavicchini, Loredana, Basilico, Nicoletta, Gamarro, Francisco, Šolaja, Bogdan A.

“…Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious…”
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Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners by Konstantinović, Jelena, Videnović, Milica, Srbljanović, Jelena, Djurković-Djaković, Olgica, Bogojević, Katarina, Sciotti, Richard, Šolaja, Bogdan

“…Malaria is a severe and life-threatening disease caused by parasites that are spread to humans through bites of infected mosquitoes. Here, we report on the…”
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Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice by Konstantinović, Jelena, Videnović, Milica, Orsini, Stefania, Bogojević, Katarina, D’Alessandro, Sarah, Scaccabarozzi, Diletta, Terzić Jovanović, Nataša, Gradoni, Luigi, Basilico, Nicoletta, Šolaja, Bogdan A.

“…In this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten…”
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Examination of the antimalarial potential of experimental aminoquinolines: poor in vitro effect does not preclude in vivo efficacy by Srbljanović, Jelena, Štajner, Tijana, Konstantinović, Jelena, Terzić-Jovanović, Nataša, Uzelac, Aleksandra, Bobić, Branko, Šolaja, Bogdan A., Djurković-Djaković, Olgica

“…•Antimalarial efficacy of a series of 26 investigational aminoquinolines examined.•Two compounds with adamantane as a carrier cured 100% of Plasmodium…”
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New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model by Konstantinović, Jelena, Kiris, Erkan, Kota, Krishna P., Tonos, Johanny Kugelman, Videnović, Milica, Cazares, Lisa H., Jovanović, Nataša Terzić, Verbić, Tatjana Ž., Andjelković, Boban, Duplantier, Allen J., Bavari, Sina, Šolaja, Bogdan A.

“…The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various…”
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Substratinspirierte Fragment‐Fusion und ‐Erweiterung führt zu wirksamen LasB‐Inhibitoren by Kaya, Cansu, Walter, Isabell, Yahiaoui, Samir, Sikandar, Asfandyar, Alhayek, Alaa, Konstantinović, Jelena, Kany, Andreas M., Haupenthal, Jörg, Köhnke, Jesko, Hartmann, Rolf W., Hirsch, Anna K. H.

“…Extrazelluläre Virulenzfaktoren haben sich als attraktive Ziele in der aktuellen Antibiotikaresistenzkrise erwiesen. Der Gram‐negative Erreger Pseudomonas…”
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Dizajn i Sinteza Inhibitora Botulinum Neurotoksina a i Parazita Plasmodium Falciparum: Benzotiofenski i Steroidni Derivati Aminohinolina by Konstantinović, Jelena M

“…Botulinum neurotoksini su najjaĉi poznati prirodni otrovi i izazivaĉi botulizma – potencijalno smrtonosne neuroparalitiĉke bolesti. U poslednje vreme, sve veći…”
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