Search Results - "Konradi, Christine"

GABAergic mechanisms of hippocampal hyperactivity in schizophrenia by Heckers, Stephan, Konradi, Christine

“…Abstract Schizophrenia is associated with abnormalities of hippocampal structure and function. Neuroimaging studies have shown that the hippocampus is…”
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Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia by Clay, Hayley B., Sillivan, Stephanie, Konradi, Christine

“…▶ Mitochondrial abnormalities are common in bipolar disorder and schizophrenia. ▶ Decreased mitochondrial respiration is frequently observed in both disorders…”
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Parvalbumin interneuron vulnerability and brain disorders by Ruden, Jacob B., Dugan, Laura L., Konradi, Christine

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Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism by Warren, Emily Booth, Aicher, Aidan Edward, Fessel, Joshua Patrick, Konradi, Christine

“…Mitochondrial DNA (mtDNA), the discrete genome which encodes subunits of the mitochondrial respiratory chain, is present at highly variable copy numbers across…”
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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging by Uzay, Burak, Houcek, Aiden, Ma, Z. Zack, Konradi, Christine, Monteggia, Lisa M., Kavalali, Ege T.

“…Rapid release of neurotransmitters in synchrony with action potentials is considered a key hardwired property of synapses. Here, in glutamatergic synapses…”
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Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosis by Konradi, Christine, Sillivan, Stephanie E, Clay, Hayley B

“…Abstract Gene expression studies of bipolar disorder (BPD) have shown changes in transcriptome profiles in multiple brain regions. Here we summarize the most…”
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Spatiotemporal Pattern of Striatal ERK1/2 Phosphorylation in a Rat Model of L-DOPA–Induced Dyskinesia and the Role of Dopamine D1 Receptors by Westin, Jenny E, Vercammen, Linda, Strome, Elissa M, Konradi, Christine, Cenci, M. Angela

“…Background We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors…”
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Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region by Wang, Alice Y., Lohmann, Kathryn M., Yang, C. Kevin, Zimmerman, Eric I., Pantazopoulos, Harry, Herring, Nicole, Berretta, Sabina, Heckers, Stephan, Konradi, Christine

“…GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical…”
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Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia by Ohlin, K. Elisabet, Francardo, Veronica, Lindgren, Hanna S., Sillivan, Stephanie E., O'Sullivan, Sean S., Luksik, Andrew S., Vassoler, Fair M., Lees, Andrew J., Konradi, Christine, Cenci, M. Angela

“…Angiogenesis and increased permeability of the blood-brain barrier have been reported to occur in animal models of Parkinson's disease and l-dopa-induced…”
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Drug-Induced Activation of Dopamine D1 Receptor Signaling and Inhibition of Class I/II Histone Deacetylase Induce Chromatin Remodeling in Reward Circuitry and Modulate Cocaine-Related Behaviors by Schroeder, Frederick A, Penta, Krista L, Matevossian, Anouch, Jones, Sara R, Konradi, Christine, Tapper, Andrew R, Akbarian, Schahram

“…Chromatin remodeling, including histone modification, is involved in stimulant-induced gene expression and addiction behavior. To further explore the role of…”
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Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques by Napolitano, Francesco, Booth Warren, Emily, Migliarini, Sara, Punzo, Daniela, Errico, Francesco, Li, Qin, Thiolat, Marie-Laure, Vescovi, Angelo Luigi, Calabresi, Paolo, Bezard, Erwan, Morelli, Micaela, Konradi, Christine, Pasqualetti, Massimo, Usiello, Alessandro

“…In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as…”
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Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue by Chartoff, Elena H, Papadopoulou, Maria, MacDonald, Matt L, Parsegian, Aram, Potter, David, Konradi, Christine, Carlezon, Jr, William A

“…The nucleus accumbens (NAc) is a critical brain area for reward and motivated behavior. Accumulating evidence suggests that altered function of the…”
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Dopamine D2‐like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP‐protein kinase A and NMDA receptor signaling by Li, Jianhong, Guo, Yin, Schroeder, Frederick A., Youngs, Rachael M., Schmidt, Thomas W., Ferris, Craig, Konradi, Christine, Akbarian, Schahram

“…Antipsychotic drugs regulate gene transcription in striatal neurons by blocking dopamine D2‐like receptors. Little is known about the underlying changes in…”
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Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder by MacDonald, Matthew L, Naydenov, Alipi, Chu, Melissa, Matzilevich, David, Konradi, Christine

“…Objectives:  Bipolar disorder (BPD) affects more than 2 million adults in the USA and ranks among the top 10 causes of worldwide disabilities. Despite its…”
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Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia by Konradi, Christine, Westin, Jenny E., Carta, Manolo, Eaton, Molly E., Kuter, Katarzyna, Dekundy, Andrzej, Lundblad, Martin, Cenci, M. Angela

“…We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa ( l-DOPA)-induced dyskinesia and Parkinson…”
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Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897–NR1 by Dudman, Joshua T., Eaton, Molly E., Rajadhyaksha, Anjali, Macías, Wendy, Taher, Muffadal, Barczak, Amy, Kameyama, Kimihiko, Huganir, Richard, Konradi, Christine

“…Addictive drugs such as amphetamine and cocaine stimulate the dopaminergic system, activate dopamine receptors and induce gene expression throughout the…”
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Mitochondrial abnormalities in the putamen in Parkinson’s disease dyskinesia by Naydenov, Alipi V., Vassoler, Fair, Luksik, Andrew S., Kaczmarska, Joanna, Konradi, Christine

“…Prolonged treatment of Parkinson’s disease (PD) with levodopa leads to disabling side effects collectively referred to as ‘dyskinesias’. We hypothesized that…”
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Animal Model Reveals Mechanism of Hippocampal Hyperactivity in Psychosis by Heckers, Stephan, Konradi, Christine

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Brain Reward Regulated by AMPA Receptor Subunits in Nucleus Accumbens Shell by Todtenkopf, Mark S, Parsegian, Aram, Naydenov, Alipi, Neve, Rachael L, Konradi, Christine, Carlezon, William A., Jr

“…Drugs of abuse alter expression of AMPA-type glutamate receptor subunits (GluRs) in the nucleus accumbens (NAc), a key component of brain reward systems. The…”
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Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium by Konradi, Christine, Leveque, Jean-Christophe, Hyman, Steven E

“…Amphetamine and cocaine induce the expression of both immediate early genes (IEGs) and neuropeptide genes in rat striatum. Despite the demonstrated dependence…”
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