Search Results - "Konrad, David B"

Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene by Konrad, David B, Savasci, Gökcen, Allmendinger, Lars, Trauner, Dirk, Ochsenfeld, Christian, Ali, Ahmed M

“…We computationally dissected the electronic and geometrical influences of ortho-chlorinated azobenzenes on their photophysical properties. X-ray analysis…”
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Synthesis of Redshifted Azobenzene Photoswitches by Late-Stage Functionalization by Konrad, David B., Frank, James A., Trauner, Dirk

“…Azobenzenes are versatile photoswitches that can be cycled between their trans‐ and cis‐configuration with light. The wavelengths required for this…”
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Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles by Urban, Patrick, Pritzl, Stefanie D, Konrad, David B, Frank, James A, Pernpeintner, Carla, Roeske, Christian R, Trauner, Dirk, Lohmüller, Theobald

“…Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying…”
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A concise synthesis of tetrodotoxin by Konrad, David B., Rühmann, Klaus-Peter, Ando, Hiroyasu, Hetzler, Belinda E., Strassner, Nina, Houk, Kendall N., Matsuura, Bryan S., Trauner, Dirk

“…Tetrodotoxin (TTX) is a neurotoxic natural product that is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and a celebrated…”
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Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow by Ketels, Marthe, Konrad, David B, Karaghiosoff, Konstantin, Trauner, Dirk, Knochel, Paul

“…A mild and general set of metalation procedures for the functionalization of unsymmetrical azobenzenes using a commercially available continuous-flow setup is…”
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Photoswitchable TRPC6 channel activators evoke distinct channel kinetics reflecting different gating behaviors by Keck, Maximilian, Hermann, Christian, Lützel, Kyra, Gudermann, Thomas, Konrad, David B., Mederos y Schnitzler, Michael, Storch, Ursula

“…The non-selective transient receptor potential canonical 6 (TRPC6) cation channels have several physiological and pathophysiological effects. They are…”
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Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening by Nippa, David F., Atz, Kenneth, Müller, Alex T., Wolfard, Jens, Isert, Clemens, Binder, Martin, Scheidegger, Oliver, Konrad, David B., Grether, Uwe, Martin, Rainer E., Schneider, Gisbert

“…Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the need to construct the…”
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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor by Donthamsetti, Prashant, Konrad, David B, Hetzler, Belinda, Fu, Zhu, Trauner, Dirk, Isacoff, Ehud Y

“…G protein-coupled receptors (GPCRs) are the most common targets of drug discovery. However, the similarity between related GPCRs combined with the complex…”
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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells by Vinogradova, Ekaterina V., Zhang, Xiaoyu, Remillard, David, Lazar, Daniel C., Suciu, Radu M., Wang, Yujia, Bianco, Giulia, Yamashita, Yu, Crowley, Vincent M., Schafroth, Michael A., Yokoyama, Minoru, Konrad, David B., Lum, Kenneth M., Simon, Gabriel M., Kemper, Esther K., Lazear, Michael R., Yin, Sifei, Blewett, Megan M., Dix, Melissa M., Nguyen, Nhan, Shokhirev, Maxim N., Chin, Emily N., Lairson, Luke L., Melillo, Bruno, Schreiber, Stuart L., Forli, Stefano, Teijaro, John R., Cravatt, Benjamin F.

“…Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine…”
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Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping by Pritzl, Stefanie D., Morstein, Johannes, Kahler, Sophia, Konrad, David B., Trauner, Dirk, Lohmüller, Theobald

“…We report on photolipid doping of giant unilamellar vesicles (GUVs) via vesicle fusion with small unilamellar photolipid vesicles (pSUVs), which enables…”
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A Lipid Photoswitch Controls Fluidity in Supported Bilayer Membranes by Urban, Patrick, Pritzl, Stefanie D, Ober, Martina F, Dirscherl, Christina F, Pernpeintner, Carla, Konrad, David B, Frank, James A, Trauner, Dirk, Nickel, Bert, Lohmueller, Theobald

“…Supported lipid bilayer (SLB) membranes are key elements to mimic membrane interfaces on a planar surface. Here, we demonstrate that azobenzene photolipids…”
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Epithelial-mesenchymal transition and H 2 O 2 signaling - a driver of disease progression and a vulnerability in cancers by Milton, Anna V, Konrad, David B

“…Mutation-selective drugs constitute a great advancement in personalized anticancer treatment with increased quality of life and overall survival in cancers…”
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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis by Freitas, Florencio Porto, Alborzinia, Hamed, dos Santos, Ancély Ferreira, Nepachalovich, Palina, Pedrera, Lohans, Zilka, Omkar, Inague, Alex, Klein, Corinna, Aroua, Nesrine, Kaushal, Kamini, Kast, Bettina, Lorenz, Svenja M., Kunz, Viktoria, Nehring, Helene, Xavier da Silva, Thamara N., Chen, Zhiyi, Atici, Sena, Doll, Sebastian G., Schaefer, Emily L., Ekpo, Ifedapo, Schmitz, Werner, Horling, Aline, Imming, Peter, Miyamoto, Sayuri, Wehman, Ann M., Genaro-Mattos, Thiago C., Mirnics, Karoly, Kumar, Lokender, Klein-Seetharaman, Judith, Meierjohann, Svenja, Weigand, Isabel, Kroiss, Matthias, Bornkamm, Georg W., Gomes, Fernando, Netto, Luis Eduardo Soares, Sathian, Manjima B., Konrad, David B., Covey, Douglas F., Michalke, Bernhard, Bommert, Kurt, Bargou, Ralf C., Garcia-Saez, Ana, Pratt, Derek A., Fedorova, Maria, Trumpp, Andreas, Conrad, Marcus, Friedmann Angeli, José Pedro

“…Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it…”
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Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids by Pritzl, Stefanie D, Konrad, David B, Ober, Martina F, Richter, Alexander F, Frank, James A, Nickel, Bert, Trauner, Dirk, Lohmüller, Theobald

“…Photoswitchable phospholipids, or “photolipids”, that harbor an azobenzene group in their lipid tails are versatile tools to manipulate and control lipid…”
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Photolipid Bilayer Permeability is Controlled by Transient Pore Formation by Pritzl, Stefanie D, Urban, Patrick, Prasselsperger, Alexander, Konrad, David B, Frank, James A, Trauner, Dirk, Lohmüller, Theobald

“…Controlling the release or uptake of (bio-) molecules and drugs from liposomes is critically important for a range of applications in bioengineering, synthetic…”
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Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion by Scheidt, Holger A., Kolocaj, Katja, Konrad, David B., Frank, James A., Trauner, Dirk, Langosch, Dieter, Huster, Daniel

“…The fusion of lipid membranes is central to many biological processes and requires substantial structural reorganization of lipids brought about by the action…”
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PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels by Leinders-Zufall, Trese, Storch, Ursula, Bleymehl, Katherin, Mederos Y Schnitzler, Michael, Frank, James A, Konrad, David B, Trauner, Dirk, Gudermann, Thomas, Zufall, Frank

“…Diacylglycerol-sensitive transient receptor potential (TRP) channels play crucial roles in a wide variety of biological processes and systems, but their…”
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DNA mimic foldamers affect chromatin composition and disturb cell cycle progression by Kleene, Vera, Corvaglia, Valentina, Chacin, Erika, Forne, Ignasi, Konrad, David B, Khosravani, Pardis, Douat, Céline, Kurat, Christoph F, Huc, Ivan, Imhof, Axel

“…Abstract The use of synthetic chemicals to selectively interfere with chromatin and the chromatin-bound proteome represents a great opportunity for…”
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Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning by Nippa, David F., Atz, Kenneth, Hohler, Remo, Müller, Alex T., Marx, Andreas, Bartelmus, Christian, Wuitschik, Georg, Marzuoli, Irene, Jost, Vera, Wolfard, Jens, Binder, Martin, Stepan, Antonia F., Konrad, David B., Grether, Uwe, Martin, Rainer E., Schneider, Gisbert

“…Late-stage functionalization is an economical approach to optimize the properties of drug candidates. However, the chemical complexity of drug molecules often…”
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In Vivo Photopharmacology Enabled by Multifunctional Fibers by Frank, James A, Antonini, Marc-Joseph, Chiang, Po-Han, Canales, Andres, Konrad, David B, Garwood, Indie C, Rajic, Gabriela, Koehler, Florian, Fink, Yoel, Anikeeva, Polina

“…Photoswitchable ligands can add an optical switch to a target receptor or signaling cascade and enable reversible control of neural circuits. The application…”
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