Search Results - "Kono, Sarah"
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Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-2022)“…SignificanceWe directly visualize DNA translocation and lesion recognition by the O -alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional…”
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TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases
Published in Nature communications (13-07-2024)“…Many CRISPR-Cas immune systems generate guide (g)RNAs using trans-activating CRISPR RNAs (tracrRNAs). Recent work revealed that Cas9 tracrRNAs could be…”
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Journal Article