Search Results - "Kono, Sarah"

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    Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies by Kono, Sarah, van den Berg, Aafke, Simonetta, Marco, Mukhortava, Ann, Garman, Elspeth F, Tessmer, Ingrid

    “…SignificanceWe directly visualize DNA translocation and lesion recognition by the O -alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional…”
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    Journal Article
  2. 2

    TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases by Jiao, Chunlei, Peeck, Natalia L., Yu, Jiaqi, Ghaem Maghami, Mohammad, Kono, Sarah, Collias, Daphne, Martinez Diaz, Sandra L., Larose, Rachael, Beisel, Chase L.

    Published in Nature communications (13-07-2024)
    “…Many CRISPR-Cas immune systems generate guide (g)RNAs using trans-activating CRISPR RNAs (tracrRNAs). Recent work revealed that Cas9 tracrRNAs could be…”
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    Journal Article