Search Results - "Kono, Mitsunori"

Discovery of the First Potent and Orally Available Agonist of the Orphan G‑Protein-Coupled Receptor 52 by Setoh, Masaki, Ishii, Naoki, Kono, Mitsunori, Miyanohana, Yuhei, Shiraishi, Eri, Harasawa, Toshiya, Ota, Hiroyuki, Odani, Tomoyuki, Kanzaki, Naoyuki, Aoyama, Kazunobu, Hamada, Teruki, Kori, Masakuni

“…G-protein-coupled receptor 52 (GPR52) is an orphan Gs-coupled G-protein-coupled receptor. GPR52 inhibits dopamine D2 receptor signaling and activates dopamine…”
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Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist by Shibata, Akira, Uga, Keiko, Sato, Takayuki, Sagara, Masaki, Igaki, Keiko, Nakamura, Yoshiki, Ochida, Atsuko, Kono, Mitsunori, Shirai, Junya, Yamamoto, Satoshi, Yamasaki, Masashi, Tsuchimori, Noboru

“…[Display omitted] Retinoic acid-related orphan receptor γt (RORγt) is a key master regulator of the differentiation and activation of IL-17 producing CD4+…”
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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)­cyclobutyl]­acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist by Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Nara, Yoshi, Fukase, Yoshiyuki, Yukawa, Tomoya, Tokuhara, Hidekazu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac D, Snell, Gyorgy P, Uga, Keiko, Shibata, Akira, Igaki, Keiko, Nakamura, Yoshiki, Nakagawa, Hideyuki, Tsuchimori, Noboru, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

“…A series of tetrahydro­naphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of…”
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Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist by Yukawa, Tomoya, Nara, Yoshi, Kono, Mitsunori, Sato, Ayumu, Oda, Tsuneo, Takagi, Terufumi, Sato, Takayuki, Banno, Yoshihiro, Taya, Naohiro, Imada, Takashi, Shiokawa, Zenyu, Negoro, Nobuyuki, Kawamoto, Tetsuji, Koyama, Ryokichi, Uchiyama, Noriko, Skene, Robert, Hoffman, Isaac, Chen, Chien-Hung, Sang, BiChing, Snell, Gyorgy, Katsuyama, Ryosuke, Yamamoto, Satoshi, Shirai, Junya

“…Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation…”
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Identification of novel quinazolinedione derivatives as RORγt inverse agonist by Fukase, Yoshiyuki, Sato, Ayumu, Tomata, Yoshihide, Ochida, Atsuko, Kono, Mitsunori, Yonemori, Kazuko, Koga, Keiko, Okui, Toshitake, Yamasaki, Masashi, Fujitani, Yasushi, Nakagawa, Hideyuki, Koyama, Ryoukichi, Nakayama, Masaharu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac, Shirai, Junya, Yamamoto, Satoshi

“…[Display omitted] Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for…”
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Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives by Kono, Mitsunori, Oda, Tsuneo, Tawada, Michiko, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Kawamoto, Tetsuji, Tokuhara, Hidekazu, Tomata, Yoshihide, Ishii, Naoki, Ochida, Atsuko, Fukase, Yoshiyuki, Yukawa, Tomoya, Fukumoto, Shoji, Watanabe, Hiroyuki, Uga, Keiko, Shibata, Akira, Nakagawa, Hideyuki, Shirasaki, Mikio, Fujitani, Yasushi, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

“…[Display omitted] A series of tetrahydroisoquinoline derivatives were designed, synthesized, and evaluated for their potential as novel orally efficacious…”
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Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds by Shirai, Junya, Tomata, Yoshihide, Kono, Mitsunori, Ochida, Atsuko, Fukase, Yoshiyuki, Sato, Ayumu, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Koyama, Ryoukichi, Nakagawa, Hideyuki, Nakayama, Masaharu, Uga, Keiko, Shibata, Akira, Koga, Keiko, Okui, Toshitake, Shirasaki, Mikio, Skene, Robert, Sang, BiChing, Hoffman, Isaac, Lane, Wes, Fujitani, Yasushi, Yamasaki, Masashi, Yamamoto, Satoshi

“…[Display omitted] A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered…”
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Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist by Nakagawa, Hideyuki, Koyama, Ryoukichi, Kamada, Yusuke, Ochida, Atsuko, Kono, Mitsunori, Shirai, Junya, Yamamoto, Satoshi, Ambrus-Aikelin, Geza, Sang, Bi-Ching, Nakayama, Masaharu

“…Retinoid-related orphan receptor gamma t (RORγt) is a master regulator of T helper 17 cells that plays a pivotal role in the production of inflammatory…”
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Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors by Kono, Mitsunori, Matsumoto, Takahiro, Kawamura, Toru, Nishimura, Atsushi, Kiyota, Yoshihiro, Oki, Hideyuki, Miyazaki, Junichi, Igaki, Shigeru, Behnke, Craig A., Shimojo, Masato, Kori, Masakuni

“…A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH)…”
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Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists by Sato, Ayumu, Fukase, Yoshiyuki, Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Sasaki, Yusuke, Ishii, Naoki, Tomata, Yoshihide, Fukumoto, Shoji, Imai, Yumi N., Uga, Keiko, Shibata, Akira, Yamasaki, Masashi, Nakagawa, Hideyuki, Shirasaki, Mikio, Skene, Robert, Hoffman, Isaac, Sang, Bi‐Ching, Snell, Gyorgy, Shirai, Junya, Yamamoto, Satoshi

“…Retinoic‐acid‐related orphan receptor γt (RORγt) inverse agonists could be used for the treatment of autoimmune diseases. Previously, we reported a novel…”
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Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors by Kono, Mitsunori, Matsumoto, Takahiro, Imaeda, Toshihiro, Kawamura, Toru, Fujimoto, Shinji, Kosugi, Yohei, Odani, Tomoyuki, Shimizu, Yuji, Matsui, Hideki, Shimojo, Masato, Kori, Masakuni

“…A series of piperazine ureas were designed, synthesized, and evaluated for their potential as novel orally efficacious fatty acid amide hydrolase (FAAH)…”
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Discovery of a 7-arylaminobenzimidazole series as novel CRF1 receptor antagonists by Mochizuki, Michiyo, Kori, Masakuni, Kono, Mitsunori, Yano, Takahiko, Sako, Yuu, Tanaka, Maiko, Kanzaki, Naoyuki, Gyorkos, Albert C., Corrette, Christopher P., Aso, Kazuyoshi

“…[Display omitted] A promising lead compound 1 of a benzimidazole series has been identified as a corticotropin-releasing factor 1 (CRF1) receptor antagonist…”
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