Search Results - "Konings, Sabine C"

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases by Fernández-Calle, Rosalía, Konings, Sabine C, Frontiñán-Rubio, Javier, García-Revilla, Juan, Camprubí-Ferrer, Lluís, Svensson, Martina, Martinson, Isak, Boza-Serrano, Antonio, Venero, José Luís, Nielsen, Henrietta M, Gouras, Gunnar K, Deierborg, Tomas

“…ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of…”
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Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability by Konings, Sabine C., Torres-Garcia, Laura, Martinsson, Isak, Gouras, Gunnar K.

“…Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk…”
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Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease by Martinsson, Isak, Quintino, Luis, Garcia, Megg G., Konings, Sabine C., Torres-Garcia, Laura, Svanbergsson, Alexander, Stange, Oliver, England, Rebecca, Deierborg, Tomas, Li, Jia-Yi, Lundberg, Cecilia, Gouras, Gunnar K.

“…Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The…”
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Fluorescently Guided Optical Photothermal Infrared Microspectroscopy for Protein-Specific Bioimaging at Subcellular Level by Prater, Craig, Bai, Yeran, Konings, Sabine C., Martinsson, Isak, Swaminathan, Vinay S., Nordenfelt, Pontus, Gouras, Gunnar, Borondics, Ferenc, Klementieva, Oxana

“…Infrared spectroscopic imaging is widely used for the visualization of biomolecule structures, and techniques such as optical photothermal infrared (OPTIR)…”
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APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis by Ramakrishna, Sarayu, Jhaveri, Vishwaja, Konings, Sabine C, Nawalpuri, Bharti, Chakraborty, Sumita, Holst, Bjørn, Schmid, Benjamin, Gouras, Gunnar K, Freude, Kristine K, Muddashetty, Ravi S

“…Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans, APOE2, APOE3, and APOE4. APOE4 is the most well-established…”
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Neurobiological role of Alzheimer’s disease genetic risk factor ApoE on early synaptic changes in Alzheimer‐like models by Konings, Sabine C, Nyberg, Emma MC, Martinsson, Isak, Gouras, Gunnar K

“…Background The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor for Alzheimer’s disease (AD). Astrocytes are the main source…”
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Apolipoprotein E intersects with amyloid-β within neurons by Konings, Sabine C, Nyberg, Emma, Martinsson, Isak, Torres-Garcia, Laura, Klementieva, Oxana, Guimas Almeida, Claudia, Gouras, Gunnar K

“…Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in…”
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The role of Alzheimer’s risk factor ApoE4 on intracellular Aβ aggregation by Konings, Sabine C, Martinsson, Isak, Nyberg, Emma MC, Gouras, Gunnar K, Klementieva, Oxana

“…Background Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer’s disease (AD). Previous research supports that ApoE4 increases amyloid‐β…”
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Studies on ApoE in the neurobiology of Alzheimer’s disease: Molecular and cell biology/endosomal‐lysosomal dysfunction by Konings, Sabine C., Martinsson, Isak, Gouras, Gunnar K.

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Studies on ApoE in the neurobiology of Alzheimer’s disease by Konings, Sabine C., Martinsson, Isak, Gouras, Gunnar K.

“…Background ApoE4, the most important genetic risk factor for Alzheimer’s disease (AD), is mainly produced by astrocytes, to some extent by microglia, and under…”
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The Effect of APOE Genotype on Endolysosomal Dynamics in Neurons by Nyberg, Emma MC, Konings, Sabine C, Lindblom, Nils JN, Klementieva, Oxana, Martinsson, Isak, Gouras, Gunnar K

“…Background APOE genotype is known as the most important genetic risk factor for developing AD. Understanding the cellular differences between the ApoE isoforms…”
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Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos by Gvazava, Nika, Konings, Sabine C., Cepeda-Prado, Efrain, Skoryk, Valeriia, Umeano, Chimezie H., Dong, Jiao, Silva, Iran A. N., Ottosson, Daniella Rylander, Leigh, Nicholas D., Wagner, Darcy Elizabeth, Klementieva, Oxana

“…Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive…”
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Correction: Apolipoprotein E intersects with amyloid-β within neurons by Konings, Sabine C, Nyberg, Emma, Martinsson, Isak, Torres-Garcia, Laura, Klementieva, Oxana, Guimas Almeida, Claudia, Gouras, Gunnar K

“…Apolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in…”
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