Search Results - "Koning, J. P."

Pancreatic β-Cell Identity Change through the Lens of Single-Cell Omics Research by Leenders, Floris, de Koning, Eelco J P, Carlotti, Françoise

“…The main hallmark in the development of both type 1 and type 2 diabetes is a decline in functional β-cell mass. This decline is predominantly attributed to…”
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Clinical use of donation after circulatory death pancreas for islet transplantation by Doppenberg, Jason B., Nijhoff, Michiel F., Engelse, Marten A., Koning, Eelco J. P.

“…Due to a shortage of donation after brain death (DBD) organs, donation after circulatory death (DCD) is increasingly performed. In the field of islet…”
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Fasting parameters for estimation of stimulated β cell function in islet transplant recipients with or without basal insulin treatment by Uitbeijerse, Bas S., Nijhoff, Michiel F., Sont, Jacob K., Koning, Eelco J. P.

“…In order to assess β cell secretory capacity after islet transplantation, standardized mixed meal stimulation tests are often used. But these tests are…”
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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling by Lund, Mari Lilith, Sorrentino, Giovanni, Egerod, Kristoffer Lihme, Kroone, Chantal, Mortensen, Brynjulf, Knop, Filip Krag, Reimann, Frank, Gribble, Fiona M, Drucker, Daniel J, de Koning, Eelco J P, Schoonjans, Kristina, Bäckhed, Fredrik, Schwartz, Thue W, Petersen, Natalia

“…Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing…”
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Organoids from the Human Fetal and Adult Pancreas by Balak, Jeetindra R. A., Juksar, Juri, Carlotti, Françoise, Lo Nigro, Antonio, de Koning, Eelco J. P.

“…Purpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and…”
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Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop by Rickels, Michael R, Stock, Peter G, de Koning, Eelco J P, Piemonti, Lorenzo, Pratschke, Johann, Alejandro, Rodolfo, Bellin, Melena D, Berney, Thierry, Choudhary, Pratik, Johnson, Paul R, Kandaswamy, Raja, Kay, Thomas W H, Keymeulen, Bart, Kudva, Yogish C, Latres, Esther, Langer, Robert M, Lehmann, Roger, Ludwig, Barbara, Markmann, James F, Marinac, Marjana, Odorico, Jon S, Pattou, François, Senior, Peter A, Shaw, James A M, Vantyghem, Marie-Christine, White, Steven

“…β-cell replacement therapy, available currently as pancreas or islet transplantation, has developed without a clear definition of graft functional and clinical…”
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DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells by Roost, Matthias S., Slieker, Roderick C., Bialecka, Monika, van Iperen, Liesbeth, Gomes Fernandes, Maria M., He, Nannan, Suchiman, H. Eka D., Szuhai, Karoly, Carlotti, Françoise, de Koning, Eelco J. P., Mummery, Christine L., Heijmans, Bastiaan T., Chuva de Sousa Lopes, Susana M.

“…Determining cell identity and maturation status of differentiated pluripotent stem cells (PSCs) requires knowledge of the transcriptional and epigenetic…”
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Pancreatic islet macroencapsulation using microwell porous membranes by Skrzypek, Katarzyna, Groot Nibbelink, Milou, van Lente, Jéré, Buitinga, Mijke, Engelse, Marten A., de Koning, Eelco J. P., Karperien, Marcel, van Apeldoorn, Aart, Stamatialis, Dimitrios

“…Allogeneic islet transplantation into the liver in combination with immune suppressive drug therapy is widely regarded as a potential cure for type 1 diabetes…”
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DNA Methylation Landscapes of Human Fetal Development by Slieker, Roderick C, Roost, Matthias S, van Iperen, Liesbeth, Suchiman, H Eka D, Tobi, Elmar W, Carlotti, Françoise, de Koning, Eelco J P, Slagboom, P Eline, Heijmans, Bastiaan T, Chuva de Sousa Lopes, Susana M

“…Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human…”
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Generation of L Cells in Mouse and Human Small Intestine Organoids by PETERSEN, Natalia, REIMANN, Frank, BARTFELD, Sina, FARIN, Henner F, RINGNALDA, Femke C, VRIES, Robert G. J, VAN DEN BRINK, Stieneke, CLEVERS, Hans, GRIBBLE, Fiona M, DE KONING, Eelco J. P

“…Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a powerful stimulant of insulin release. Strategies to augment endogenous GLP-1…”
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long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation by Cnop, M, Hughes, S. J, Igoillo-Esteve, M, Hoppa, M. B, Sayyed, F, van de Laar, L, Gunter, J. H, de Koning, E. J. P, Walls, G. V, Gray, D. W. G, Johnson, P. R. V, Hansen, B. C, Morris, J. F, Pipeleers-Marichal, M, Cnop, I, Clark, A

“…Aims/hypothesis Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta…”
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Association between person and disease related factors and the planned diabetes care in people who receive person-centered type 2 diabetes care: An implementation study by van Vugt, Heidi A, de Koning, Eelco J P, Rutten, Guy E H M

“…To assess the planned diabetes care for the coming year and its associated factors in patients with Type 2 diabetes who have a person-centered annual…”
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Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior? by Mostert-Kerckhoffs, M. A. L., Willems, A. E., Tenback, D. E., Koning, J. P., Van Harten, P., Staal, W. G.

“…Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and…”
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A High Cell‐Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans by Skrzypek, Katarzyna, Groot Nibbelink, Milou, Liefers‐Visser, Jolanda, Smink, Alexandra M., Stoimenou, Eleftheria, Engelse, Marten A., Koning, Eelco J. P., Karperien, Marcel, Vos, Paul, Apeldoorn, Aart, Stamatialis, Dimitrios

“…Macroencapsulation of islets of Langerhans is a promising strategy for transplantation of insulin‐producing cells in the absence of immunosuppression to treat…”
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Advances in β-cell replacement therapy for the treatment of type 1 diabetes by Vantyghem, Marie-Christine, de Koning, Eelco J P, Pattou, François, Rickels, Michael R

“…The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to reduce disease complications. For some patients, technological…”
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COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course by Landstra, Cyril P, de Koning, Eelco J P

“…The relationship between COVID-19 and diabetes mellitus is complicated and bidirectional. On the one hand, diabetes mellitus is considered one of the most…”
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Factors that influence the intended intensity of diabetes care in a person‐centred setting by Vugt, H. A., Heijmans, M. J. W. M., Koning, E. J. P., Rutten, G. E. H. M.

“…Aims To assess the intended intensity of Type 2 diabetes care and the factors associated with that intensity of care after the annual monitoring visit in which…”
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The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion by Spinnler, Robert, Gorski, Theresa, Stolz, Katharina, Schuster, Susanne, Garten, Antje, Beck-Sickinger, Annette G, Engelse, Marten A, de Koning, Eelco J P, Körner, Antje, Kiess, Wieland, Maedler, Kathrin

“…Obesity is associated with a dysregulation of beta-cell and adipocyte function. The molecular interactions between adipose tissue and beta-cells are not yet…”
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Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice by Ellenbroek, J. H., Töns, H. A. M., Westerouen van Meeteren, M. J. A., de Graaf, N., Hanegraaf, M. A., Rabelink, T. J., Carlotti, F., de Koning, E. J. P.

“…Aims/hypothesis Incretin-based therapies improve glycaemic control in patients with type 2 diabetes. In animal models of diabetes, glucagon-like peptide-1…”
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Glycemic Stability Through Islet‐After‐Kidney Transplantation Using an Alemtuzumab‐Based Induction Regimen and Long‐Term Triple‐Maintenance Immunosuppression by Nijhoff, M. F., Engelse, M. A., Dubbeld, J., Braat, A. E., Ringers, J., Roelen, D. L., Erkel, A. R., Spijker, H. S., Bouwsma, H., Boog, P. J. M., Fijter, J. W., Rabelink, T. J., Koning, E. J. P.

“…Pancreatic islet transplantation is performed in a select group of patients with type 1 diabetes mellitus. Immunosuppressive regimens play an important role in…”
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