Search Results - "Konieczkowski, David J"

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors by Konieczkowski, David J, Johannessen, Cory M, Abudayyeh, Omar, Kim, Jong Wook, Cooper, Zachary A, Piris, Adriano, Frederick, Dennie T, Barzily-Rokni, Michal, Straussman, Ravid, Haq, Rizwan, Fisher, David E, Mesirov, Jill P, Hahn, William C, Flaherty, Keith T, Wargo, Jennifer A, Tamayo, Pablo, Garraway, Levi A

“…Most melanomas harbor oncogenic BRAF(V600) mutations, which constitutively activate the MAPK pathway. Although MAPK pathway inhibitors show clinical benefit in…”
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Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival by Upadhyay, Rituraj, Dhakal, Aastha, Wheeler, Caroline, Hoyd, Rebecca, Jagjit Singh, Malvenderjit, Karivedu, Vidhya, Bhateja, Priyanka, Bonomi, Marcelo, Valentin, Sasha, Gamez, Mauricio E, Konieczkowski, David J, Baliga, Sujith, Grecula, John C, Blakaj, Dukagjin M, Gogineni, Emile, Mitchell, Darrion L, Denko, Nicholas C, Spakowicz, Daniel, Jhawar, Sachin R

“…Head and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response and prognosis. The tumor microenvironment…”
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Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer by Börcsök, Judit, Sztupinszki, Zsofia, Bekele, Raie, Gao, Sizhi P, Diossy, Miklos, Samant, Amruta S, Dillon, Kasia M, Tisza, Viktoria, Spisák, Sándor, Rusz, Orsolya, Csabai, Istvan, Pappot, Helle, Frazier, Zoë J, Konieczkowski, David J, Liu, David, Vasani, Naresh, Rodrigues, James A, Solit, David B, Hoffman-Censits, Jean H, Plimack, Elizabeth R, Rosenberg, Jonathan E, Lazaro, Jean-Bernard, Taplin, Mary-Ellen, Iyer, Gopa, Brunak, Søren, Lozsa, Rita, Van Allen, Eliezer M, Szüts, Dávid, Mouw, Kent W, Szallasi, Zoltan

“…Cisplatin-based chemotherapy is a first-line treatment for muscle-invasive and metastatic urothelial cancer. Approximately 10% of bladder urothelial tumors…”
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Characterizing genomic alterations in cancer by complementary functional associations by Kim, Jong Wook, Botvinnik, Olga B, Abudayyeh, Omar, Birger, Chet, Rosenbluh, Joseph, Shrestha, Yashaswi, Abazeed, Mohamed E, Hammerman, Peter S, DiCara, Daniel, Konieczkowski, David J, Johannessen, Cory M, Liberzon, Arthur, Alizad-Rahvar, Amir Reza, Alexe, Gabriela, Aguirre, Andrew, Ghandi, Mahmoud, Greulich, Heidi, Vazquez, Francisca, Weir, Barbara A, Van Allen, Eliezer M, Tsherniak, Aviad, Shao, Diane D, Zack, Travis I, Noble, Michael, Getz, Gad, Beroukhim, Rameen, Garraway, Levi A, Ardakani, Masoud, Romualdi, Chiara, Sales, Gabriele, Barbie, David A, Boehm, Jesse S, Hahn, William C, Mesirov, Jill P, Tamayo, Pablo

“…Complementary genomic features associated with pathway activation, gene dependency and drug sensitivity are uncovered using REVEALER. Systematic efforts to…”
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Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers by Dhakal, Aastha, Upadhyay, Rituraj, Wheeler, Caroline, Hoyd, Rebecca, Karivedu, Vidhya, Gamez, Mauricio E, Valentin, Sasha, Vanputten, Meade, Bhateja, Priyanka, Bonomi, Marcelo, Konieczkowski, David J, Baliga, Sujith, Mitchell, Darrion L, Grecula, John C, Blakaj, Dukagjin M, Denko, Nicholas C, Jhawar, Sachin R, Spakowicz, Daniel

“…Purpose/Objective(s): Microbiome has been shown to affect tumorigenesis by promoting inflammation. However, the association between the upper aerodigestive…”
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Radiation therapy for retroperitoneal sarcoma: practice patterns in North America by Ruff, Samantha M, Heh, Victor, Konieczkowski, David J, Onuma, Amblessed, Dunlop, Hayley M, Kim, Alex C, Grignol, Valerie P, Contreras, Carlo M, Pawlik, Timothy M, Pollock, Raphael, Beane, Joal D

“…The addition of radiation therapy (RT) to surgery in retroperitoneal sarcoma (RPS) remains controversial. We examined practice patterns in the use of RT for…”
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A Convergence-Based Framework for Cancer Drug Resistance by Konieczkowski, David J., Johannessen, Cory M., Garraway, Levi A.

“…Despite advances in cancer biology and therapeutics, drug resistance remains problematic. Resistance is often multifactorial, heterogeneous, and prone to…”
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Resistance to EGFR blockade in colorectal cancer： liquid biopsies and latent subclones by Konieczkowski, David J, Garraway, Levi A

“…Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that…”
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Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States by Kim, Jong Wook, Abudayyeh, Omar O, Yeerna, Huwate, Yeang, Chen-Hsiang, Stewart, Michelle, Jenkins, Russell W, Kitajima, Shunsuke, Konieczkowski, David J, Medetgul-Ernar, Kate, Cavazos, Taylor, Mah, Clarence, Ting, Stephanie, Van Allen, Eliezer M, Cohen, Ofir, Mcdermott, John, Damato, Emily, Aguirre, Andrew J, Liang, Jonathan, Liberzon, Arthur, Alexe, Gabriella, Doench, John, Ghandi, Mahmoud, Vazquez, Francisca, Weir, Barbara A, Tsherniak, Aviad, Subramanian, Aravind, Meneses-Cime, Karina, Park, Jason, Clemons, Paul, Garraway, Levi A, Thomas, David, Boehm, Jesse S, Barbie, David A, Hahn, William C, Mesirov, Jill P, Tamayo, Pablo

“…The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the…”
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Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning by Serluca, Fabrizio C, Xu, Bo, Okabe, Noriko, Baker, Kari, Lin, Shin-Yi, Sullivan-Brown, Jessica, Konieczkowski, David J, Jaffe, Kimberly M, Bradner, Joshua M, Fishman, Mark C, Burdine, Rebecca D

“…Cilia defects have been implicated in a variety of human diseases and genetic disorders, but how cilia motility contributes to these phenotypes is still…”
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Radiation-associated secondary malignancies: a novel opportunity for applying immunotherapies by Atajanova, Tavus, Rahman, Md Mahfuzur, Konieczkowski, David J., Morris, Zachary S.

“…Radiation is commonly used as a treatment intended to cure or palliate cancer patients. Despite remarkable advances in the precision of radiotherapy delivery,…”
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Contemporary and Emerging Approaches to Bladder-Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer by Konieczkowski, David J., Efstathiou, Jason A., Mouw, Kent W.

“…Bladder-preserving trimodality therapy (TMT), consisting of trans-urethral bladder tumor resection followed by concurrent chemoradiotherapy, is an established…”
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A WT1 Co-regulator Controls Podocyte Phenotype by Shuttling between Adhesion Structures and Nucleus by Srichai, Manakan B, Konieczkowski, Martha, Padiyar, Aparna, Konieczkowski, David J, Mukherjee, Amitava, Hayden, Patrick S, Kamat, Sweta, El-Meanawy, M Ashraf, Khan, Shenaz, Mundel, Peter, Lee, Sean Bong, Bruggeman, Leslie A, Schelling, Jeffrey R, Sedor, John R

“…Glomerular podocyte differentiation state is critical for filtration barrier function and is regulated by WT1, a zinc finger transcription factor. A yeast…”
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Robust VMAT treatment planning for extremity soft tissue sarcomas by Barrus, Joshua, Fernando, Katelyn, Addington, Mark, Lenards, Nishele, Hunzeker, Ashley, Konieczkowski, David J

“…Volumetric modulated arc therapy (VMAT) is a frequently employed and guideline-recommended radiotherapy (RT) modality for extremity soft tissue sarcomas…”
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Radiation Strategies for Spine Chordoma: Proton Beam, Carbon Ions, and Stereotactic Body Radiation Therapy by Konieczkowski, David J, DeLaney, Thomas F, Yamada, Yoshiya Josh

“…Surgery alone provides suboptimal local control of spine and sacral chordomas. Radiotherapy (RT) may improve local control in patients undergoing surgery and…”
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Disparities in survival outcomes among Black patients with HPV‐associated oropharyngeal cancer by Baliga, Sujith, Mitchell, Darrion, Yildiz, Vedat O., Gogineni, Emile, Konieczkowski, David J., Grecula, John, Blakaj, Dukagjin M., Liu, Xuefeng, Gamez, Mauricio E.

“…Patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV‐OPSCC) have a favorable prognosis and excellent overall survival (OS),…”
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Preoperative radiation therapy increases adherence in patients with high-risk extremity soft tissue sarcoma by Dunlop, Hayley M., Atchison, T.J., Zeh, Ryan, Konieczkowski, David J., Kim, Alex, Grignol, Valerie P., Contreras, Carlo M., Obeng-Gyasi, Samilia, Pawlik, Timothy M., Pollock, Raphael E., Beane, Joal D.

“…Surgery and radiation therapy remain the standard of care for patients with high-grade extremity soft tissue sarcoma that are >5 cm. Radiation therapy is time…”
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CGE24-096: Impact of Somatic Mutations on Outcomes of Salvage Radiation and Hormonal Therapy for Prostate Cancer Recurrence After Prostatectomy by Otani, Keisuke, Konieczkowski, David J, Rodden, Daniel J, Wu, Shulin, Davicioni, Elai, Saylor, Philip J, Dahl, Douglas M, Wu, Chin-Lee, Kamran, Sophia C, Efstathiou, Jason A, Miyamoto, David T

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Disparities in Survival and NCCN Guideline-Concordant Care in Patients With Extremity Soft Tissue Sarcoma by Dunlop, Hayley M, Bende, Bence, Ruff, Samantha M, Kim, Alex, Fisher, James L, Grignol, Valerie P, Contreras, Carlo M, Obeng-Gyasi, Samilia, Konieczkowski, David J, Pawlik, Timothy M, Pollock, Raphael E, Beane, Joal D

“…Based on the NCCN Guidelines for Soft Tissue Sarcoma (STS), treatment of extremity STS (ESTS) includes radiation therapy (RT) and surgical resection for tumors…”
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Low‐dose preoperative radiation, resection, and reduced‐field postoperative radiation for soft tissue sarcomas by Konieczkowski, David J., Goldberg, Saveli I., Raskin, Kevin A., Lozano‐Calderon, Santiago, Mullen, John T., Chen, Yen‐Lin, DeLaney, Thomas F.

“…Background and Objectives Radiotherapy (RT) enables conservative surgery for soft tissue sarcoma (STS). RT can be delivered either pre‐operatively (PreRT) or…”
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