Search Results - "Konieczka, Jay H"

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering by Adolfsen, Kristin J., Callihan, Isolde, Monahan, Catherine E., Greisen, Per Jr, Spoonamore, James, Momin, Munira, Fitch, Lauren E., Castillo, Mary Joan, Weng, Lindong, Renaud, Lauren, Weile, Carl J., Konieczka, Jay H., Mirabella, Teodelinda, Abin-Fuentes, Andres, Lawrence, Adam G., Isabella, Vincent M.

“…In phenylketonuria (PKU) patients, a genetic defect in the enzyme phenylalanine hydroxylase (PAH) leads to elevated systemic phenylalanine (Phe), which can…”
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Evolutionary principles of modular gene regulation in yeasts by Thompson, Dawn A, Roy, Sushmita, Chan, Michelle, Styczynsky, Mark P, Pfiffner, Jenna, French, Courtney, Socha, Amanda, Thielke, Anne, Napolitano, Sara, Muller, Paul, Kellis, Manolis, Konieczka, Jay H, Wapinski, Ilan, Regev, Aviv

“…Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the…”
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A genome-wide analysis of FRT-like sequences in the human genome by Shultz, Jeffry L, Voziyanova, Eugenia, Konieczka, Jay H, Voziyanov, Yuri

“…Efficient and precise genome manipulations can be achieved by the Flp/FRT system of site-specific DNA recombination. Applications of this system are limited,…”
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Correction: Evolutionary principles of modular gene regulation in yeasts by Thompson, Dawn A, Roy, Sushmita, Chan, Michelle, Styczynski, Mark P, Pfiffner, Jenna, French, Courtney, Socha, Amanda, Thielke, Anne, Napolitano, Sara, Muller, Paul, Kellis, Manolis, Konieczka, Jay H, Wapinski, Ilan, Regev, Aviv

“…[This corrects the article DOI: 10.7554/eLife.00603.]…”
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Stepwise Manipulation of DNA Specificity in Flp Recombinase: Progressively Adapting Flp to Individual and Combinatorial Mutations in its Target Site by Voziyanov, Yuri, Konieczka, Jay H., Francis Stewart, A., Jayaram, Makkuni

“…The Flp protein from Saccharomyces cerevisiae is one of the site-specific tyrosine family recombinases that are used widely in genomic engineering. As a first…”
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ArrayIDer: automated structural re-annotation pipeline for DNA microarrays by van den Berg, Bart Hj, Konieczka, Jay H, McCarthy, Fiona M, Burgess, Shane C

“…Systems biology modeling from microarray data requires the most contemporary structural and functional array annotation. However, microarray annotations,…”
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Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata by Chen, Ying-Lien, Konieczka, Jay H, Springer, Deborah J, Bowen, Samantha E, Zhang, Jing, Silao, Fitz Gerald S, Bungay, Alice Alma C, Bigol, Ursela G, Nicolas, Marilou G, Abraham, Soman N, Thompson, Dawn A, Regev, Aviv, Heitman, Joseph

“…Candida glabrata is an emerging human fungal pathogen that is frequently drug tolerant, resulting in difficulties in treatment and a higher mortality in…”
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Evolution of variants of yeast site-specific recombinase Flp that utilize native genomic sequences as recombination target sites by Bolusani, Swetha, Ma, Chien-Hui, Paek, Andrew, Konieczka, Jay H, Jayaram, Makkuni, Voziyanov, Yuri

“…As a tool in directed genome manipulations, site-specific recombination is a double-edged sword. Exquisite specificity, while highly desirable, makes it…”
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Arsenic Exposure Perturbs Epithelial-Mesenchymal Cell Transition and Gene Expression In a Collagen Gel Assay by Lencinas, Alejandro, Broka, Derrick M., Konieczka, Jay H., Klewer, Scott E., Antin, Parker B., Camenisch, Todd D., Runyan, Raymond B.

“…Arsenic is a naturally occurring metalloid and environmental contaminant. Arsenic exposure in drinking water is reported to cause cancer of the liver, kidneys,…”
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Secondary Structure Switching in Cro Protein Evolution by Newlove, Tracey, Konieczka, Jay H, Cordes, Matthew H.J

“…We report the solution structure of the Cro protein from bacteriophage P22. Comparisons of its sequence and structure to those of λ Cro strongly suggest an…”
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BioNetBuilder2.0: bringing systems biology to chicken and other model organisms by Konieczka, Jay H, Drew, Kevin, Pine, Alex, Belasco, Kevin, Davey, Sean, Yatskievych, Tatiana A, Bonneau, Richard, Antin, Parker B

“…Systems Biology research tools, such as Cytoscape, have greatly extended the reach of genomic research. By providing platforms to integrate data with molecular…”
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Genomic resources for chicken by Antin, Parker B., Konieczka, Jay H.

“…The recent sequencing and draft assembly of a chicken genome has provided biologists with an invaluable research tool that complements a growing list of…”
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Recombination of Hybrid Target Sites by Binary Combinations of Flp Variants: Mutations that Foster Interprotomer Collaboration and Enlarge Substrate Tolerance by Konieczka, Jay H, Paek, Andrew, Jayaram, Makkuni, Voziyanov, Yuri

“…Strategies of directed evolution and combinatorial mutagenesis applied to the Flp site-specific recombinase have yielded recombination systems that utilize…”
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MicroRNA expression during chick embryo development by Darnell, Diana K., Kaur, Simran, Stanislaw, Stacey, Konieczka, Jay K., Yatskievych, Tatiana A., Antin, Parker B.

“…MicroRNAs (miRNAs) are small, abundant, noncoding RNAs that modulate protein abundance by interfering with target mRNA translation or stability. miRNAs are…”
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MicroRNA expression during chick embryo development by Darnell, Diana K., Kaur, Simran, Stanislaw, Stacey, Konieczka, Jay H., Yatskievych, Tatiana A., Antin, Parker B.

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