Determination of peritoneal membrane transport characteristics with dialysis adequacy and transport test in Thai patients

The characteristics of peritoneal membrane transport are useful for the determination of dialysis treatment prescription. The peritoneal equilibration test (PET) is accepted as a gold standard tool for identification of these characteristics. Unfortunately, the process of PET is troublesome and unsu...

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Bibliographic Details
Published in:	Journal of the Medical Association of Thailand Vol. 94 Suppl 4; p. S81
Main Authors:	Kaitwatcharachai, Charoen, Aden, Jaruda, Kongkid, Khamanut, Kitpiboonchai, Tharntip, Kaitwatcharachai, Somthawil
Format:	Journal Article
Language:	English
Published:	Thailand 01-09-2011
Subjects:	Adult Aged Asian Continental Ancestry Group Biological Transport Creatinine - analysis Creatinine - metabolism Dialysis Solutions - analysis Female Humans Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Kidney Function Tests - methods Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory Peritoneum - chemistry Peritoneum - metabolism Predictive Value of Tests Sensitivity and Specificity Thailand Young Adult Thailand
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Summary:	The characteristics of peritoneal membrane transport are useful for the determination of dialysis treatment prescription. The peritoneal equilibration test (PET) is accepted as a gold standard tool for identification of these characteristics. Unfortunately, the process of PET is troublesome and unsuitable for clinical practice. Dialysis adequacy and transport test (DATT), which is easier and more convenient method, is proposed as an alternative test. The aim of the present study was to evaluate the accuracy of the DATT in determination of membrane characteristics in Thai patients. Fifteen patients underwent both DATT and PET on the same day. The second DATT was performed. The 24-hour dialysate-to-plasma ratio of creatinine (D/Pcr) from each DATT was compared with the adjusted 4-hour D/Pcr from the corresponding PET. The types of membrane solute transport were classified using the PET proposed by Twardowski and the DATT suggested by Rocco into high, high average, low average, and low transporter The mean age was 48.1 +/- 16.4 years. The mean value of D/Pcr derived from DATT was higher than PET (0.80 +/- 0.10 vs. 0.74 +/- 0.14). The results of both D/Pcr were correlated (r = 0.78, p = 0.001). However, determinations of characteristics of membrane transport were discordant (kappa coefficient = 0.25). The results of the repeated D/Pcr were not different and the classification of membrane transport properties were concordant (kappa coefficient = 0.68). The results of D/Pcr derived from both tests were correlated. However determinations of characteristics of membrane transport were discordant.
ISSN:	0125-2208