New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA s...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 62; no. 11; pp. 1484 - 1487
Main Authors:	Seo, E.K, Huang, L, Wall, M.E, Wani, M.C, Navarro, H, Mukherjee, R, Farnsworth, N.R, Konghorn, A.D
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-11-1999 Glendale, AZ American Society of Pharmacognosy
Subjects:	antineoplastic agents Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Benzopyrans - isolation & purification Benzopyrans - pharmacology Biological and medical sciences biphenyl Catechols - isolation & purification Catechols - pharmacology cell lines Cell Survival - drug effects Central America chemical constituents of plants chemical structure chromosome breakage Clusia clusiparalicolines cytotoxic compounds derivatives DNA DNA, Neoplasm - drug effects General pharmacology Humans kb cell lines KB Cells Magnetic Resonance Spectroscopy Medical sciences medicinal plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - isolation & purification Phenols - pharmacology Plant Roots - chemistry Plants, Medicinal - chemistry roots South America spectral analysis Spectrophotometry, Infrared Brazil South America America Central America Antineoplastic agent Guttiferae Cytotoxicity Oxygen heterocycle Diphenols Scission Medicinal plant Polyphenol Folk medicine Dicotyledones Angiospermae Bicyclic compound Aromatic compound Human Root Pharmacognosy In vitro Biological activity Cell line Biphenyl derivatives DNA KB cell line Plant origin Phenols Isolation Spermatophyta Structural analysis
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Summary:	Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
Bibliography:	istex:333529E0F0745AF5C05E466DD247E50BDF02E6C7 ark:/67375/TPS-39BKZPLR-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9900775