Search Results - "Kong, Xiangduo"

NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival by Murata, Michael M, Kong, Xiangduo, Moncada, Emmanuel, Chen, Yumay, Imamura, Hiromi, Wang, Ping, Berns, Michael W, Yokomori, Kyoko, Digman, Michelle A

“…DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor…”
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The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA by Yusufzai, Timur, Kong, Xiangduo, Yokomori, Kyoko, Kadonaga, James T

“…HepA-related protein (HARP) (also known as SMARCAL1) is an ATP-driven annealing helicase that catalyzes the formation of dsDNA from complementary Replication…”
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Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei by Jiang, Shan, Williams, Katherine, Kong, Xiangduo, Zeng, Weihua, Nguyen, Nam Viet, Ma, Xinyi, Tawil, Rabi, Yokomori, Kyoko, Mortazavi, Ali

“…FSHD is characterized by the misexpression of DUX4 in skeletal muscle. Although DUX4 upregulation is thought to be the pathogenic cause of FSHD, DUX4 is lowly…”
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Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs by Morris, Tessa Altair, Naik, Jasmine, Fibben, Kirby Sinclair, Kong, Xiangduo, Kiyono, Tohru, Yokomori, Kyoko, Grosberg, Anna

“…As sarcomeres produce the force necessary for contraction, assessment of sarcomere order is paramount in evaluation of cardiac and skeletal myocytes. The…”
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Single-nucleus RNA-seq of differentiating human myoblasts reveals the extent of fate heterogeneity by Zeng, Weihua, Jiang, Shan, Kong, Xiangduo, El-Ali, Nicole, Ball, Jr, Alexander R, Ma, Christopher I-Hsing, Hashimoto, Naohiro, Yokomori, Kyoko, Mortazavi, Ali

“…Myoblasts are precursor skeletal muscle cells that differentiate into fused, multinucleated myotubes. Current single-cell microfluidic methods are not…”
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DNA damage induced during mitosis undergoes DNA repair synthesis by Gomez Godinez, Veronica, Kabbara, Sami, Sherman, Adria, Wu, Tao, Cohen, Shirli, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Shi, Zhixia, Preece, Daryl, Yokomori, Kyoko, Berns, Michael W

“…Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by…”
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Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair by Kong, Xiangduo, Cruz, Gladys Mae Saquilabon, Trinh, Sally Loyal, Zhu, Xu-Dong, Berns, Michael W, Yokomori, Kyoko

“…TRF2 (TERF2) binds to telomeric repeats and is critical for telomere integrity. Evidence suggests that it also localizes to non-telomeric DNA damage sites…”
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Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl by Wu, Nan, Kong, Xiangduo, Ji, Zhejian, Zeng, Weihua, Potts, Patrick Ryan, Yokomori, Kyoko, Yu, Hongtao

“…DNA double-strand breaks (DSBs) fuel cancer-driving chromosome translocations. Two related structural maintenance of chromosomes (Smc) complexes, cohesin and…”
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A novel YAG:Ce/CsI:Tl phoswich detector consisting of transparent ceramic scintillator for α–γ discrimination by Qu, Huan, Li, Chengqian, Lu, Jingbin, Wang, H. D., Li, Ruopu, Kong, Xiangduo, Liu, Xinrui

“…Developing a ceramic scintillator operating in a phoswich detector is a feasible way for pulse shape discrimination. A YAG:Ce transparent ceramic scintillator…”
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Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair by Kong, Xiangduo, Ball, Alexander R., Pham, Hoang Xuan, Zeng, Weihua, Chen, Hsiao-Yuan, Schmiesing, John A., Kim, Jong-Soo, Berns, Michael, Yokomori, Kyoko

“…Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Application of Laser Microirradiation in the Investigations of Cellular Responses to DNA Damage by Kong, Xiangduo, Wakida, Nicole M., Yokomori, Kyoko

“…Since the laser has been invented it has been highly instrumental in ablating different parts of the cell to test their functionality. Through induction of…”
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Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression by Wu, Shumin, Wang, Weiping, Kong, Xiangduo, Congdon, Lauren M, Yokomori, Kyoko, Kirschner, Marc W, Rice, Judd C

“…Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially…”
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Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites by Saquilabon Cruz, Gladys Mae, Kong, Xiangduo, Silva, Bárbara Alcaraz, Khatibzadeh, Nima, Thai, Ryan, Berns, Michael W, Yokomori, Kyoko

“…Laser microirradiation is a powerful tool for real-time single-cell analysis of the DNA damage response (DDR). It is often found, however, that factor…”
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Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation by Kong, Xiangduo, Nguyen, Nam Viet, Li, Yumeng, Sakr, Jasmine Shaaban, Williams, Kate, Sharifi, Sheila, Chau, Jonathan, Bayrakci, Altay, Mizuno, Seiya, Takahashi, Satoru, Kiyono, Tohru, Tawil, Rabi, Mortazavi, Ali, Yokomori, Kyoko

“…Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4…”
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Laser-Induced Nuclear Damage Signaling and Communication in Astrocyte Networks Through Parp-Dependent Calcium Oscillations by Wakida, Nicole M., Ha, Ryan D., Kim, Edward K., Kong, Xiangduo, Yokomori, Kyoko, Berns, Michael W.

“…Astrocytes are known to respond to various perturbations with oscillations of calcium, including to cellular injury. Less is known about astrocytes’ ability to…”
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Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1 by Kong, Xiangduo, Stephens, Jared, Ball, Jr, Alexander R, Heale, Jason T, Newkirk, Daniel A, Berns, Michael W, Yokomori, Kyoko

“…Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to…”
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Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD) by Zeng, Weihua, de Greef, Jessica C, Chen, Yen-Yun, Chien, Richard, Kong, Xiangduo, Gregson, Heather C, Winokur, Sara T, Pyle, April, Robertson, Keith D, Schmiesing, John A, Kimonis, Virginia E, Balog, Judit, Frants, Rune R, Ball, Jr, Alexander R, Lock, Leslie F, Donovan, Peter J, van der Maarel, Silvère M, Yokomori, Kyoko

“…Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in which no mutation of pathogenic gene(s) has been identified. Instead, the…”
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In Situ Analysis of DNA Damage Response and Repair Using Laser Microirradiation by Kim, Jong‐Soo, Heale, Jason T., Zeng, Weihua, Kong, Xiangduo, Krasieva, Tatiana B., Ball, Alexander R., Yokomori, Kyoko

“…A proper response to DNA damage is critical for the maintenance of genome integrity. However, it is difficult to study the in vivo kinetics and factor…”
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Single-cell spatial transcriptomics reveals a dystrophic trajectory following a developmental bifurcation of myoblast cell fates in facioscapulohumeral muscular dystrophy by Chen, Lujia, Kong, Xiangduo, Johnston, Kevin G, Mortazavi, Ali, Holmes, Todd C, Tan, Zhiqun, Yokomori, Kyoko, Xu, Xiangmin

“…Facioscapulohumeral muscular dystrophy (FSHD) is linked to abnormal derepression of the transcription activator DUX4. This effect is localized to a low…”
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Chromatin Dynamics during DNA Repair Revealed by Pair Correlation Analysis of Molecular Flow in the Nucleus by Hinde, Elizabeth, Kong, Xiangduo, Yokomori, Kyoko, Gratton, Enrico

“…Chromatin dynamics modulate DNA repair factor accessibility throughout the DNA damage response. The spatiotemporal scale upon which these dynamics occur render…”
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