Search Results - "Kong, Milene"

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration by Alvarez, Alvaro, Lagos-Cabré, Raúl, Kong, Milene, Cárdenas, Areli, Burgos-Bravo, Francesca, Schneider, Pascal, Quest, Andrew F.G., Leyton, Lisette

“…Our previous reports indicate that ligand-induced αVβ3 integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes…”
Get full text

αVβ3 Integrin regulates astrocyte reactivity by Lagos-Cabrn, Raul, Alvarez, Alvaro, Kong, Milene, Burgos-Bravo, Francesca, Cardenas, Areli, Rojas-Mancilla, Edgardo, Pnrez-Nueez, Ramon, Herrera-Molina, Rodrigo, Rojas, Fabiola, Schneider, Pascal, Herrera-Marschitz, Mario, Quest, Andrew F. G, van Zundert, Brigitte, Leyton, Lisette

“…BACKGROUNDNeuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3…”
Get full text

Participation of the Human Sperm Proteasome in the Capacitation Process and Its Regulation by Protein Kinase A and Tyrosine Kinase by Kong, Milene, Diaz, Emilce S, Morales, Patricio

“…The proteasome is a multicatalytic cellular complex present in human sperm that plays a significant role during several steps of mammalian fertilization. Here,…”
Get full text

Protein Kinase A (PRKA) Activity Is Regulated by the Proteasome at the Onset of Human Sperm Capacitation by Zapata-Carmona, Héctor, Barón, Lina, Kong, Milene, Morales, Patricio

“…The proteasome increases its activity at the onset of sperm capacitation due to the action of the SACY/PRKACA pathway; this increase is required for…”
Get full text

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells by Valdivia, Alejandra, Cárdenas, Areli, Brenet, Marianne, Maldonado, Horacio, Kong, Milene, Díaz, Jorge, Burridge, Keith, Schneider, Pascal, San Martín, Alejandra, García-Mata, Rafael, Quest, Andrew F G, Leyton, Lisette

“…Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage…”
Get full text

Thy-1-Interacting Molecules and Cellular Signaling in Cis and Trans by Herrera-Molina, Rodrigo, Valdivia, Alejandra, Kong, Milene, Alvarez, Alvaro, Cárdenas, Areli, Quest, Andrew F.G., Leyton, Lisette

“…Thy-1, discovered almost 50 years ago, was for many years a subject of great scientific interest. The putative functions attributed to this molecule could not…”
Get full text

ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation by Henríquez, Mauricio, Herrera-Molina, Rodrigo, Valdivia, Alejandra, Alvarez, Alvaro, Kong, Milene, Muñoz, Nicolás, Eisner, Verónica, Jaimovich, Enrique, Schneider, Pascal, Quest, Andrew F G, Leyton, Lisette

“…Thy-1, an abundant mammalian glycoprotein, interacts with αvβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and…”
Get full text

Effect of fibronectin on proteasome activity, acrosome reaction, tyrosine phosphorylation and intracellular calcium concentrations of human sperm by Diaz, Emilce S., Kong, Milene, Morales, Patricio

“…BACKGROUND Previously we showed that the human sperm proteasome plays significant roles during mammalian fertilization. Here we studied the effect of…”
Get full text

Role of the sperm proteasome during fertilization and gamete interaction in the mouse by Pasten, Consuelo, Morales, Patricio, Kong, Milene

“…In this work, we have investigated the role of the sperm proteasome during in vitro fertilization (IVF) and gamete interaction in the mouse. Proteasome…”
Get full text

Participation of the Human Sperm Proteasome in the Capacitation Process and Its Regulation by Protein Kinase A and Tyrosine Kinase1 by Kong, Milene, Diaz, Emilce S, Morales, Patricio

“…The proteasome is a multicatalytic cellular complex present in human sperm that plays a significant role during several steps of mammalian fertilization. Here,…”
Get full text

The activation of the chymotrypsin-like activity of the proteasome is regulated by soluble adenyl cyclase/cAMP/protein kinase A pathway and required for human sperm capacitation by Zapata-Carmona, Héctor, Barón, Lina, Zuñiga, Lidia M, Díaz, Emilce Silvina, Kong, Milene, Drobnis, Erma Z, Sutovsky, Peter, Morales, Patricio

“…One of the first events of mammalian sperm capacitation is the activation of the soluble adenyl cyclase/cAMP/protein kinase A (SACY/cAMP/PKA) pathway. Here, we…”
Get full text

Thy-1-mediated cell–cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 by Kong, Milene, Muñoz, Nicolás, Valdivia, Alejandra, Alvarez, Alvaro, Herrera-Molina, Rodrigo, Cárdenas, Areli, Schneider, Pascal, Burridge, Keith, Quest, Andrew F.G., Leyton, Lisette

“…Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which…”
Get full text

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation by Martínez‐León, Eduardo, Osycka‐Salut, Claudia, Signorelli, Janetti, Kong, Milene, Morales, Patricio, Pérez‐Martínez, Silvina, Díaz, Emilce Silvina

“…Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been…”
Get full text

Participation of the sperm proteasome in human fertilization by Morales, Patricio, Kong, Milene, Pizarro, Eduardo, Pasten, Consuelo

“…BACKGROUND: Fertilization in mammals comprises the sequential interactions of the sperm with the cumulus oophorus, zona pellucida, and oocyte plasma membrane…”
Get full text

Extracellular localization of proteasomes in human sperm by Morales, Patricio, Pizarro, Eduardo, Kong, Milene, Jara, Marcos

“…The proteasome, a multienzymatic protease complex is present in human sperm. Here we present evidence indicating that the proteasome has an extracellular…”
Get full text

α V β 3 Integrin regulates astrocyte reactivity by Lagos-Cabré, Raúl, Alvarez, Alvaro, Kong, Milene, Burgos-Bravo, Francesca, Cárdenas, Areli, Rojas-Mancilla, Edgardo, Pérez-Nuñez, Ramón, Herrera-Molina, Rodrigo, Rojas, Fabiola, Schneider, Pascal, Herrera-Marschitz, Mario, Quest, Andrew F G, van Zundert, Brigitte, Leyton, Lisette

“…Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging α β Integrin…”
Get full text

AlphaVBeta3 Integrin regulates astrocyte reactivity by Lagos-Cabre, Raul, Alvarez, Alvaro, Kong, Milene, Burgos-Bravo, Francesca, Cardenas, Areli, Rojas-Mancilla, Edgardo, Perez-Nunez, Ramon, Herrera-Molina, Rodrigo, Rojas, Fabiola, Schneider, Pascal, Herrera-Marschitz, Mario, Quest, Andrew F G, Brigitte van Zundert, Leyton, Lisette

“…Background Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3…”
Get full text

Proteasomal activity in mammalian spermatozoa by Pizarro, Eduardo, Pastén, Consuelo, Kong, Milene, Morales, Patricio

“…The proteasome is a multicatalytic cellular complex, which possess three different enzymatic activities, trypsin‐like, chymotrypsin‐like, and peptidylglutamyl…”
Get full text

Proteasome activity and its relationship with protein phosphorylation during capacitation and acrosome reaction in human spermatozoa by Morales, Patricio, Díaz, Emilce S, Kong, Milene

“…We have shown that the proteasome is present in mammalian sperm and plays a role during fertilisation. In this work we studied the relationship between protein…”
Get more information

Gonadotropin-Releasing Hormone-Stimulated Sperm Binding to the Human Zona Is Mediated by a Calcium Influx by MORALES, P, PIZARRO, E, KONG, M, KERR, B, CERIC, F, VIGIL, P

“…The mechanism by which GnRH increases sperm-zona pellucida binding in humans was investigated in this study. We tested whether GnRH increases sperm-zona…”
Get full text