Search Results - "Kong, Lingheng"

Cobalt(III)- and Rhodium(III)-Catalyzed C–H Amidation and Synthesis of 4‑Quinolones: C–H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone by Wang, Fen, Jin, Liang, Kong, Lingheng, Li, Xingwei

“…Cobalt­(III) and rhodium­(III) catalysts exhibited complementary scope in C–H amidation of aryl enaminones. The amidation reactions proceeded with broad scope…”
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Rhodium(III)-Catalyzed Synthesis of Naphthols via C–H Activation of Sulfoxonium Ylides by Xu, Youwei, Yang, Xifa, Zhou, Xukai, Kong, Lingheng, Li, Xingwei

“…Direct and efficient synthesis of 1-naphthols has been realized via Rh­(III)-catalyzed C–H activation of sulfoxonium ylides and subsequent annulation with…”
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Access to Structurally Diverse Quinoline-Fused Heterocycles via Rhodium(III)-Catalyzed C–C/C–N Coupling of Bifunctional Substrates by Yu, Songjie, Li, Yunyun, Zhou, Xukai, Wang, He, Kong, Lingheng, Li, Xingwei

“…Rhodium­(III)-catalyzed C–H activation of heteroarenes and functionalization with bifunctional substrates such as anthranils allows facile construction of…”
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Manganese(I)-Catalyzed Synthesis of Fused Eight- and Four-Membered Carbocycles via C–H Activation and Pericyclic Reactions by Xu, Youwei, Zheng, Guangfan, Kong, Lingheng, Li, Xingwei

“…Pericyclic reactions have allowed facile construction of complex cycles. On the other hand, metal-catalyzed C–H activation has been established as an important…”
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Access to Quaternary Stereogenic Centers via Rhodium(III)-Catalyzed Annulations between 2‑Phenylindoles and Ketenes by Yang, Xifa, Li, Yunyun, Kong, Lingheng, Li, Xingwei

“…Rh­(III)-catalyzed C–H activation of arenes and mild oxidative [4 + 2] annulative coupling with ketenes have been realized. The uniquely high reactivity of the…”
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Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer by Sui, Qiaoqi, Zhang, Xi, Chen, Chao, Tang, Jinghua, Yu, Jiehai, Li, Weihao, Han, Kai, Jiang, Wu, Liao, Leen, Kong, Lingheng, Li, Yuan, Hou, Zhenlin, Zhou, Chi, Zhang, Chenzhi, Zhang, Linjie, Xiao, Binyi, Mei, Weijian, Xu, Yanbo, Qin, Jiayi, Zheng, Jian, Pan, Zhizhong, Ding, Pei-Rong

“…Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles in tumor progression and immunosuppression…”
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Mild Acylation of C(sp3)–H and C(sp2)–H Bonds under Redox-Neutral Rh(III) Catalysis by Yu, Songjie, Li, Yingzi, Kong, Lingheng, Zhou, Xukai, Tang, Guodong, Lan, Yu, Li, Xingwei

“…Carbonyl groups are ubiquitous in functional molecules. Although C–H bond acylation has been well-studied via different mechanisms, transition-metal-catalyzed…”
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Rhodium-Catalyzed Oxidative Synthesis of Quinoline-Fused Sydnones via 2‑fold C–H Bond Activation by Li, Lei, Wang, He, Yang, Xifa, Kong, Lingheng, Wang, Fen, Li, Xingwei

“…Rh­(III)-catalyzed synthesis of mesoionic heterocycles has been achieved via C–H activation of sydnones and oxidative coupling with internal alkynes. This…”
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The effects of oxaliplatin-based adjuvant chemotherapy in high-risk stage II colon cancer with mismatch repair-deficient: a retrospective study by Liao, Leen, Tang, Jinghua, Hong, Zhigang, Jiang, Wu, Li, Yuan, Kong, Lingheng, Han, Kai, Hou, Zhenlin, Zhang, Chenzhi, Zhou, Chi, Zhang, Linjie, Sui, Qiaoqi, Xiao, Binyi, Mei, Weijian, Yu, Jiehai, Yang, Wanjun, Pan, Zhizhong, Ding, Pei-Rong

“…For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study…”
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Comparisons of screening strategies for identifying Lynch syndrome among patients with MLH1-deficient colorectal cancer by Xiao, Binyi, Luo, Jun, Xie, E, Kong, Lingheng, Tang, Jinghua, Liu, Dingxin, Mao, Linlin, Sui, Qiaoqi, Li, Weirong, Hong, Zhigang, Pan, Zhizhong, Jiang, Wu, Ding, Pei-Rong

“…BRAF and MLH1 promoter methylation testings have been proven effective prescreens for Lynch Syndrome. We aimed to compare different screening strategies for…”
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Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study by Sui, Qiaoqi, Zheng, Jian, Liu, Dingxin, Peng, Jianhong, Ou, Qingjian, Tang, Jinghua, Li, Yuan, Kong, Lingheng, Jiang, Wu, Xiao, Binyi, Chao, Xue, Pan, Zhizhong, Zhang, Huizhong, Ding, Pei-Rong

“…It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver…”
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miR-634 inhibits human vascular smooth muscle cell proliferation and migration in hypertension through Wnt4/β-catenin pathway by Niu, Ligang, Sun, Na, Kong, Lingheng, Xu, Yan, Kang, Yuming

“…MicroRNAs (miRNAs) have been regarded as modulators in vascular pathologies, including hypertension. Dysregulated proliferation and migration of VSMCs…”
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Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer by Sui, Qiaoqi, Liu, Dingxin, Jiang, Wu, Tang, Jinghua, Kong, Lingheng, Han, Kai, Liao, Leen, Li, Yuan, Ou, Qingjian, Xiao, Binyi, Liu, Guochen, Ling, Yihong, Chen, Jiewei, Liu, Zexian, Zuo, Zhixiang, Pan, Zhizhong, Zhou, Penghui, Zheng, Jian, Ding, Pei-Rong

“…BackgroundDickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1)…”
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The apolipoprotein B and apolipoprotein A-I Ratio serves as a strong prognostic factor for the overall survival of patients with colorectal cancer by Pan, Yangxun, Ye, Zhiwei, Ling, Yihong, Kong, Lingheng, Wang, Chenwei, Chen, Gong, Wan, Desen, Chen, Minshan, Hu, Dandan

“…The lipid metabolism status of patients with colorectal cancer (CRC) has not been understood comprehensively. The present study investigated the…”
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A novel screening method of DNA methylation biomarkers helps to improve the detection of colorectal cancer and precancerous lesions by Li, Yuan, Li, Bin, Jiang, Rou, Liao, Leen, Zheng, Chunting, Yuan, Jie, Zeng, Liuhong, Hu, Kunling, Zhang, Yuyu, Mei, Weijian, Hong, Zhigang, Xiao, Binyi, Kong, Lingheng, Han, Kai, Tang, Jinghua, Jiang, Wu, Pan, Zhizhong, Zhang, Shenyan, Ding, Peirong

“…Abstract Background Colorectal cancer (CRC) is one of the most common malignancies, and early detection plays a crucial role in enhancing curative outcomes…”
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Decreased endometrial vascularity in patients with antiphospholipid antibodies–associated recurrent miscarriage during midluteal phase by Chen, Leining, M.D, Quan, Song, M.D, Ou, Xiang-hong, M.D., Ph.D, Kong, Lingheng, M.D., Ph.D

“…Objective To explore uterine arterial impedance and endometrial-subendometrial vascularity determined by two-dimensional Doppler ultrasonography (2D-DU) and…”
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Cobalt(III)-Catalyzed Regio- and Stereoselective α‑Fluoroalkenylation of Arenes with gem-Difluorostyrenes by Kong, Lingheng, Zhou, Xukai, Li, Xingwei

“…A cobalt­(III)-catalyzed α-fluoroalkenylation of different arenes with readily available gem-difluorostyrenes has been realized under mild and redox-neutral…”
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Twofold C−H Activation‐Based Enantio‐ and Diastereoselective C−H Arylation Using Diarylacetylenes as Rare Arylating Reagents by Hu, Panjie, Kong, Lingheng, Wang, Fen, Zhu, Xiaolin, Li, Xingwei

“…C−H bond activation has been established as an attractive strategy to access axially chiral biaryls, and the most straightforward method is direct C−H…”
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Redox-Neutral Couplings between Amides and Alkynes via Cobalt(III)-Catalyzed C–H Activation by Kong, Lingheng, Yu, Songjie, Zhou, Xukai, Li, Xingwei

“…C–H activation assisted by a bifunctional directing group has allowed the construction of heterocycles. This is ideally catalyzed by earth-abundant and…”
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Rhodium-Catalyzed Atroposelective C–H Arylation of (Hetero)Arenes Using Carbene Precursors as Arylating Reagents by Zou, Yun, Wang, Peiyuan, Kong, Lingheng, Li, Xingwei

“…Rhodium­(III)-catalyzed C–H activation-based arylation of sterically hindered (hetero)­arenes has been realized using diazo compounds and triazoles as…”
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