Search Results - "Kong, Anne M"
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Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications
Published in PloS one (22-02-2016)“…Here, we describe a porous 3-dimensional collagen scaffold material that supports capillary formation in vitro, and promotes vascularization when implanted in…”
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2
A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly
Published in Nature communications (25-11-2022)“…Time-lapse mechanical properties of stem cell derived cardiac organoids are important biological cues for understanding contraction dynamics of human heart…”
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3
Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle
Published in Acta biomaterialia (01-08-2019)“…[Display omitted] Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a tissue flap…”
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4
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
Published in Cell death discovery (05-03-2018)“…Human induced pluripotent stem cells (iPSCs) are a valuable tool for studying the cardiac developmental process in vitro, and cardiomyocytes derived from iPSCs…”
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Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells
Published in Stem cells international (2019)“…Human induced pluripotent stem cells (iPSCs) can be differentiated in vitro into bona fide cardiomyocytes for disease modelling and personalized medicine…”
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6
Liver specification of human iPSC-derived endothelial cells transplanted into mouse liver
Published in JHEP reports (01-05-2024)“…Liver sinusoidal endothelial cells (LSECs) are important in liver development, regeneration, and pathophysiology, but the differentiation process underlying…”
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Engineering transplantable human lymphatic and blood capillary networks in a porous scaffold
Published in Journal of tissue engineering (01-01-2022)“…Due to a relative paucity of studies on human lymphatic assembly in vitro and subsequent in vivo transplantation, capillary formation and survival of primary…”
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A Tissue Engineering Chamber for Continuous Pulsatile Electrical Stimulation of Vascularized Cardiac Tissues In Vivo
Published in Bioelectricity (01-12-2020)“…Background: Cardiomyocytes derived from pluripotent stem cells are immature. Maturation of cardiomyocytes is a multifactorial dynamic process that involves…”
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Real-time electro-mechanical profiling of dynamically beating human cardiac organoids by coupling resistive skins with microelectrode arrays
Published in Biosensors & bioelectronics (01-01-2025)“…Cardiac organoids differentiated from induced pluripotent stem cells are emerging as a promising platform for pre-clinical drug screening, assessing…”
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10
Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction
Published in Cardiovascular research (22-02-2021)“…Abstract Aims To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be…”
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11
The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2
Published in The international journal of biochemistry & cell biology (01-11-2005)“…Phosphoinositides are membrane-bound signaling molecules that recruit, activate and localize target effectors to intracellular membranes regulating apoptosis,…”
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Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction
Published in Cardiovascular drugs and therapy (21-10-2024)Get full text
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13
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease
Published in Journal of autoimmunity (01-06-2012)“…Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by the production of autoantibodies against nuclear components…”
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14
Identification of P-Rex1 as a Novel Rac1-Guanine Nucleotide Exchange Factor (GEF) That Promotes Actin Remodeling and GLUT4 Protein Trafficking in Adipocytes
Published in The Journal of biological chemistry (16-12-2011)“…Phosphoinositide 3-kinase (PI3K) signaling promotes the translocation of the glucose transporter, GLUT4, to the plasma membrane in insulin-sensitive tissues to…”
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Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection
Published in Journal of Molecular and Cellular Cardiology Plus (Online) (01-09-2024)“…Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury…”
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Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Is Generated at the Plasma Membrane by an Inositol Polyphosphate 5-Phosphatase: Endogenous PtdIns(3)P Can Promote GLUT4 Translocation to the Plasma Membrane
Published in Molecular and Cellular Biology (01-08-2006)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup
Published in Blood (15-12-2007)“…Macrophages phagocytose particles to resolve infections and remove apoptotic cells. Phosphoinositide 3-kinase generates…”
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Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays
Published in Methods in molecular biology (Clifton, N.J.) (2009)“…Phosphatidylinositol 3,4,5 trisphosphate [PtdIns(3,4,5)P3] is a potent membrane-bound signaling molecule transiently synthesized by phosphoinositide 3-kinase…”
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SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton
Published in Blood (01-08-2003)“…The platelet receptor for the von Willebrand factor (VWF) glycoprotein Ib-IX-V (GPIb-IX-V) complex mediates platelet adhesion at sites of vascular injury. The…”
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Cloning and Characterization of a 72-kDa Inositol-polyphosphate 5-Phosphatase Localized to the Golgi Network
Published in The Journal of biological chemistry (04-08-2000)“…The inositol-polyphosphate 5-phosphatase enzyme family removes the 5-position phosphate from both inositol phosphate and phosphoinositide signaling molecules…”
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