Search Results - "Kong, A N"

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains by Kim, J-H, Yu, S, Chen, J D, Kong, A N

“…Nuclear factor erythroid 2-related factor 2 (Nrf2, NM 006164, 605 AA) is essential for the antioxidant responsive element (ARE)-mediated expression of a group…”
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Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis by Nair, S, Doh, S T, Chan, J Y, Kong, A-N, Cai, L

“…Many studies have implicated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor- κ B1 (Nfkb1) in inflammation and cancer. However, the regulatory…”
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Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals by Chen, Chi, Pung, Daniel, Leong, Vasco, Hebbar, Vidya, Shen, Guoxiang, Nair, Sujit, Li, Wenge, Tony Kong, A.-N.

“…Garlic organosulfur compounds (OSCs) are recognized as a group of potential chemopreventive compounds. It is known that garlic OSCs can modulate drug…”
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Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain by Li, Wenge, Yu, Si-Wang, Kong, A.-N. Tony

“…NF-E2-related factor 2 (Nrf2) is the key transcription factor regulating the antioxidant response. Previous studies identified a nuclear localization signal…”
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Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif by Li, Wenge, Yu, Siwang, Liu, Tong, Kim, Jung-Hwan, Blank, Volker, Li, Hong, Kong, A.-N. Tony

“…Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to oxidative stress, Nrf2 translocates to cell nucleus and forms…”
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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes by Rushmore, Thomas H, Kong, A-N Tony

“…Drug or xenobiotics metabolizing enzymes (DMEs or XMEs) play central roles in the biotransformation, metabolism and/or detoxification of xenobiotics or foreign…”
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Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death by Chen, C, Yu, R, Owuor, E D, Kong, A N

“…Green tea polyphenols (GTP) have been demonstrated to suppress tumorigenesis in several chemical-induced animal carcinogenesis models, and predicted as…”
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Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane by KIM, Bok-Ryang, HU, Rong, KEUM, Young-Sam, HEBBAR, Vidya, SHEN, Guoxiang, NAIR, Sujit S, KONG, A.-N. Tony

“…Sulforaphane (SFN) and its N-acetyl-L-cysteine (NAC) conjugate are effective inhibitors of tumorigenesis in animal models. These compounds induce the…”
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The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells by Hu, Rong, Kim, Bok Ryang, Chen, Chi, Hebbar, Vidya, Kong, A.-N.Tony

“…Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is present naturally in widely consumed vegetables, especially in watercress. It has…”
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In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat by Hu, Rong, Hebbar, Vidya, Kim, Bok-Ryang, Chen, Chi, Winnik, Bozena, Buckley, Brian, Soteropoulos, Patricia, Tolias, Peter, Hart, Ronald P, Kong, A-N Tony

“…Sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive compounds that has been shown to be effective in blocking initiation and…”
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Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice by Shen, Guoxiang, Xu, Changjiang, Hu, Rong, Jain, Mohit R, Nair, Sujit, Lin, Wen, Yang, Chung S, Chan, Jefferson Y, Kong, A-N Tony

“…This study was conducted to study global gene expression profiles elicited by (-)-epigallocatechin-3-gallate (EGCG) in mouse liver and small intestine, as well…”
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Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates by Chen, Yi-Rong, Wang, Wenfu, Kong, A.-N. Tony, Tan, Tse-Hua

“…Isothiocyanates have strong chemopreventive properties against many carcinogen-induced cancers in experimental animal models. Here, we report that phenylmethyl…”
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Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism by Yu, Rong, Chen, Chi, Mo, Yin-Yuan, Hebbar, Vidya, Owuor, Edward D., Tan, Tse-Hua, Kong, A.-N. Tony

“…Antioxidant response element (ARE) regulates the induction of a number of cellular antioxidant and detoxifying enzymes. However, the signaling pathways that…”
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Phenylethyl Isothiocyanate Induces Apoptotic Signaling via Suppressing Phosphatase Activity against c-Jun N-terminal Kinase by Chen, Yi-Rong, Han, Jin, Kori, Rajashree, Kong, A-N Tony, Tan, Tse-Hua

“…Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism. We found that phenylethyl…”
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Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity by YU, R, MANDLEKAR, S, HARVEY, K. J, UCKER, D. S, KONG, A.-N. T

“…Isothiocyanates exert strong anticarcinogenic effects in a number of animal models of cancer, presumably by modulation of xenobiotic-metabolizing enzymes, such…”
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Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals by Yu, Rong, Lei, Wei, Mandlekar, Sandhya, Weber, Michael J., Der, Channing J., Wu, Jie, Kong, A.-N. Tony

“…Mitogen-activated protein kinase (MAPK) cascades are activated by diverse extracellular signals and participate in the regulation of an array of cellular…”
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Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif by Li, Wenge, Jain, Mohit R, Chen, Chi, Yue, Xin, Hebbar, Vidya, Zhou, Renping, Kong, A-N Tony

“…Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant response. Under homeostatic conditions Nrf2 is anchored to…”
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Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE) by Kong, A.-N. Tony, Owuor, Edward, Yu, Rong, Hebbar, Vidya, Chen, Chi, Hu, Rong, Mandlekar, Sandhya

“…Cellular responses to xenobiotic-induced stress can signal proliferation, differentiation, homeostasis, apoptosis, or necrosis. To better understand the…”
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Toxicogenomics of resveratrol in rat liver by Hebbar, Vidya, Shen, Guoxiang, Hu, Rong, Kim, Bok-Ryang, Chen, Chi, Korytko, Peter J., Crowell, James A., Levine, Barry S., Kong, A.-N. Tony

“…Resveratrol, a polyphenolic compound found in grape skin and peanuts has been shown to prevent many diseases including cardiovascular diseases and cancer. To…”
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Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells by RONG YU, MANDLEKAR, S, RUBEN, S, JIAN NI, KONG, A.-N. T

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce cell death in a variety of transformed cells but spared the normal…”
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