Search Results - "Koneti Rao, A"

Gray platelet syndrome: immunity goes awry by Rao, A. Koneti, Rao, Deepak A.

“…In this issue of Blood , Sims et al 1 describe clinical, genotypic, and phenotypic findings in 47 patients with the gray platelet syndrome (GPS), a rare…”
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RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency by Kaur, Gurpreet, Jalagadugula, Gauthami, Mao, Guangfen, Rao, A. Koneti

“…Haploinsufficiency of RUNX1 (also known as CBFA2/AML1) is associated with familial thrombocytopenia, platelet dysfunction, and predisposition to acute…”
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Platelet disorders: the next generation is in by Rao, A.Koneti, Songdej, Natthapol

“…In this issue of Blood, Simeoni et al describe exciting results using a high-throughput sequencing (HTS) platform with 63 targeted genes in patients with…”
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Inherited platelet dysfunction and hematopoietic transcription factor mutations by Songdej, Natthapol, Rao, A. Koneti

“…Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most…”
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Editorial: Platelet Genomics and Disorders of Platelet Number and Function by Rao, A. Koneti

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Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency by Jalagadugula, Gauthami, Mao, Guangfen, Kaur, Gurpreet, Goldfinger, Lawrence E., Dhanasekaran, Danny N., Rao, A. Koneti

“…Mutations in transcription factor RUNX1 are associated with familial platelet disorder, thrombocytopenia, and predisposition to leukemia. We have described a…”
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P2Y12 receptor inhibition and LPS-induced coagulation by Essex, David W, Rao, A Koneti

“…Platelets play a major role in the complex interactions involved in blood coagulation via multiple mechanisms. As reported in this issue, Schoergenhofer et al…”
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Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand by VAIDYULA, Vijender R, RAO, A. Koneti, MOZZOLI, Maria, HOMKO, Carol, CHEUNG, Peter, BODEN, Guenther

“…Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand Vijender R. Vaidyula 1 , A. Koneti…”
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Whole-Blood Tissue Factor Procoagulant Activity Is Elevated in Type 1 Diabetes: Effects of hyperglycemia and hyperinsulinemia by Singh, Anamika, Boden, Guenther, Homko, Carol, Gunawardana, Jay, Rao, A. Koneti

“…OBJECTIVE: To determine tissue factor procoagulant activity (TF-PCA) in patients with type 1 diabetes and to examine effects of hyperglycemia and hyperglycemia…”
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Hematopoietic transcription factor mutations and inherited platelet dysfunction by Songdej, Natthapol, Rao, A Koneti

“…The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown. There is increasing evidence that mutations in…”
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Platelet Protein Kinase C-θ Deficiency With Human RUNX1 Mutation: PRKCQ Is a Transcriptional Target of RUNX1 by Jalagadugula, Gauthami, Mao, Guangfen, Kaur, Gurpreet, Dhanasekaran, Danny N, Rao, A. Koneti

“…OBJECTIVE—Mutations in the hematopoietic transcription factor RUNX1 cause thrombocytopenia and impaired platelet function. In a patient with a heterozygous…”
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Circulating tissue factor procoagulant activity is elevated in stable moderate to severe chronic obstructive pulmonary disease by Vaidyula, Vijender Reddy, Criner, Gerard J, Grabianowski, Carla, Rao, A. Koneti

“…Abstract Introduction Chronic obstructive pulmonary disease (COPD) patients have increased risk for cardiovascular mortality and venous thromboembolism. Tissue…”
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Hematopoietic transcription factor mutations: important players in inherited platelet defects by Songdej, Natthapol, Rao, A.Koneti

“…Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most…”
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A procoagulant state and endothelial dysfunction in obese children – response to Blann by Rao, A. Koneti, Komaroff, Eugene, Singh, Anamika, Foster, Gary D.

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Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control by Gentile, Nina T., Rao, A. Koneti, Reimer, Hannah, Del Carpio‐Cano, Fabiola, Ramakrishnan, Viswanathan, Pauls, Qi, Barsan, William G., Bruno, Askiel

“…Alterations in coagulation could mediate functional outcome in patients with hyperglycemia after acute ischemic stroke (AIS). We prospectively studied the…”
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Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer by Voora, Deepak, Rao, A. Koneti, Jalagadugula, Gauthami S., Myers, Rachel, Harris, Emily, Ortel, Thomas L., Ginsburg, Geoffrey S.

“…Aspirin prevents cardiovascular disease and colon cancer; however aspirin's inhibition of platelet COX-1 only partially explains its diverse effects. We…”
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RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events by Guan, Liying, Voora, Deepak, Myers, Rachel, Del Carpio-Cano, Fabiola, Rao, A. Koneti

“…Hematopoietic transcription factor RUNX1 is expressed from proximal P2 and distal P1 promoters to yield isoforms RUNX1 B and C, respectively. The roles of…”
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Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects by Vaidyula, Vijender R., Boden, Guenther, Rao, A. Koneti

“…Type 2 diabetes mellitus (T2DM) patients have hyperglycemia and hyperinsulinemia and increased risk of atherosclerosis and acute vascular complications. We…”
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Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor by Jalagadugula, Gauthami, Goldfinger, Lawrence E., Mao, Guangfen, Lambert, Michele P., Rao, A. Koneti

“…Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression…”
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Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload by Guo, Xinji, Kolpakov, Mikhail A, Hooshdaran, Bahman, Schappell, William, Wang, Tao, Eguchi, Satoru, Elliott, Katherine J, Tilley, Douglas G, Rao, A Koneti, Andrade-Gordon, Patricia, Bunce, Matthew, Madhu, Chintala, Houser, Steven R, Sabri, Abdelkarim

“…Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear. In mice…”
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